Results 41 to 50 of about 96,185 (308)

Drug delivery in overcoming the blood-brain barrier: role of nasal mucosal grafting [PDF]

, 2017
The blood–brain barrier (BBB) plays a fundamental role in protecting and maintaining the homeostasis of the brain. For this reason, drug delivery to the brain is much more difficult than that to other compartments of the body. In order to bypass or cross
Carafa, Maria, Di Marzio, Luisa, Hanieh, PATRIZIA NADIA, Marianecci, Carlotta, Paolino, Donatella, Rinaldi, Federica   +5 more
core   +1 more source

Development and evaluation of vinpocetine inclusion complex for brain targeting

Asian Journal of Pharmaceutical Sciences, 2015
The objective of this paper is to prepare vinpocetine (VIN) inclusion complex and evaluate its brain targeting effect after intranasal administration. In the present study, VIN inclusion complex was prepared in order to increase its solubility. Stability
Jiaojiao Ding, Jinfeng Li, Shirui Mao
doaj   +1 more source

Pharmacometric Modeling of the Impact of Azelastine Nasal Spray on SARS-CoV-2 Viral Load and Related Symptoms in COVID-19 Patients

Pharmaceutics, 2022
The histamine-1 receptor antagonist azelastine was recently found to impact SARS-CoV-2 viral kinetics in a Phase 2 clinical trial (CARVIN). Thus, we investigated the relationship between intranasal azelastine administrations and viral load, as well as ...
Christiane Dings, Peter Meiser, Frank Holzer, Michael Flegel, Dominik Selzer, Eszter Nagy, Ralph Mösges, Jens Peter Klussmann, Thorsten Lehr   +8 more
doaj   +1 more source

Carbon nanotubes induce inflammation but decrease the production of reactive oxygen species in lung [PDF]

, 2010
With the rapid spread of carbon nanotubes (CNTs) applications, the respiratory toxicity of these compounds has attracted the attention of many scientists. Several studies have reported that after lung administration, CNTs could induce granuloma, fibrosis,
Arnaud, R., Castellarin, C., Crouzier, David, Dabouis, Vincent, Debouzy, Jean-Claude, Flahaut, Emmanuel, Follot, S., Gentilhomme, Edgar   +7 more
core   +1 more source

Salivary Oxytocin Concentrations in Males following Intranasal Administration of Oxytocin: A Double-Blind, Cross-Over Study.

PLoS ONE, 2015
The use of intranasal oxytocin (OT) in research has become increasingly important over the past decade. Although researchers have acknowledged a need for further investigation of the physiological effects of intranasal administration, few studies have ...
Katie Daughters, Antony S R Manstead, Kelly Hubble, Aled Rees, Anita Thapar, Stephanie H M van Goozen   +5 more
doaj   +1 more source

Advances and Challenges in Intranasal Delivery of Antipsychotic Agents Targeting the Central Nervous System

Frontiers in Pharmacology, 2022
Treatment of central nervous system (CNS) disorders is challenging using conventional delivery strategies and routes of administration because of the presence of the blood–brain barrier (BBB). This BBB restricts the permeation of most of the therapeutics
Manisha Pandey, Neha Jain, Jovita Kanoujia, Zahid Hussain, Bapi Gorain   +4 more
doaj   +1 more source

The pharmacokinetics of intranasal droperidol in volunteers characterised via population modelling

SAGE Open Medicine, 2018
Background: Droperidol is used parenterally to treat nausea and vomiting, migraine and acute behavioural disturbance. Intranasal use is not reported for droperidol.
Isabelle Cooper, Cornelia B Landersdorfer, Ashley Gordon St John, Andis Graudins   +3 more
doaj   +1 more source

Using Oral and Intranasal Dosage Forms of Ketamine for Managing Treatment-Resistant Depression: A Review of the Literature

International Journal of Medical Students, 2016
A lack of effective treatment for patients with treatment-resistant depression (TRD) has led to the evaluation of ketamine, an N-methyl- D-aspartate receptor antagonist.
Patrick Arthur Twohig, Vaughn Huckfeldt
doaj   +1 more source

Efficacy of intranasal administration of artesunate in experimental cerebral malaria [PDF]

, 2014
BACKGROUND: Improving management of patients suffering from cerebral malaria is needed to reduce the devastating mortality and morbidity of the disease in endemic areas.
Adeline Lavoignat, Anne Marijon, Anne-Lise Bienvenu, Anthony Fourier, Coralie Bringer, Guillaume Bonnot, Marie-Claude Gagnieu, Stéphane Picot   +7 more
core   +2 more sources

Intranasal Pharmacokinetics of Morphine ARER, a Novel Abuse-Deterrent Formulation: Results from a Randomized, Double-Blind, Four-Way Crossover Study in Nondependent, Opioid-Experienced Subjects

Pain Research and Management, 2018
Objective. To investigate the pharmacokinetics (PK) of Morphine ARER, an extended-release (ER), abuse-deterrent formulation of morphine sulfate after oral and intranasal administration. Methods.
Lynn R. Webster, Carmela Pantaleon, Matthew Iverson, Michael D. Smith, Eric R. Kinzler, Stefan Aigner   +5 more
doaj   +1 more source