Results 61 to 70 of about 96,185 (308)

Intranasal administration of allergen increases specific IgE whereas intranasal omalizumab does not increase serum IgE levels : a pilot study [PDF]

, 2018
Background: Administration of the therapeutic anti-IgE antibody omalizumab to patients induces strong increases in IgE antibody levels. Objective: To investigate the effect of intranasal administration of major birch pollen allergen Bet v 1, omalizumab ...
Bischoff, Cameron, Chan, Chanez, Christianson, Chu, Dema, Eckl-Dorna, Egger, Egger, Gevaert, Ghetie, Gieras, Hauswirth, Hayashi, Humbert, Ishizaka, Jabara, Jardieu, Kaplan, Katona, KleinJan, Laffer, Lawrence, Lowe, Lupinek, MacGlashan, Mizuma, Naclerio, Nakamura, Narayanan, Niederberger, Noga, Noga, Ota, Platts-Mills, Steinberger, Stokes, Valent   +38 more
core   +1 more source

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

Bioavailability of butorphanol after intranasal administration to horses.

Bulgarian Journal of Veterinary Medicine, 2020
The aim of the present study was to describe butorphanol pharmacokinetics and bioavailability following intranasal administration to horses. Six adult horses received 0.05 mg/kg butorphanol, in a randomised crossover design, by either intravenous or ...
V. Ferreira, M. I. Velloso , M. F. Landoni   +2 more
doaj   +1 more source

Neuroenhancement of exposure therapy in anxiety disorders [PDF]

, 2015
Although exposure-based treatments and anxiolytic medications are more effective than placebo for treating anxiety disorders, there is still considerable room for further improvement.
Curtiss, Joshua, Hofmann, Stefan G., Mundy, Elizabeth A.   +2 more
core   +2 more sources

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science, EarlyView.
This study aims to evaluate the impact of the potassium channel KCNJ2 on asthma development. KCNJ2 promotes NLRP3 inflammasome activation through both Ca2+ influx and K+ efflux in airway epithelial cells, which drives allergic airway inflammation and remodeling, suggesting a promising therapeutic target for asthma.
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
wiley   +1 more source

Intranasal fentanyl for pain control: current status with a focus on patient considerations

Patient Preference and Adherence, 2011
Eric Prommer, Lisa ThompsonDivision of Hematology/Oncology, Mayo Clinic College of Medicine, Mayo Clinic Hospital, Scottsdale, AZ, USAAbstract: Of several newer delivery systems under development and investigation for the administration of opioids, the ...
Eric Prommer, Lisa Thompson
doaj  

Penetration Enhancers for the Development of Intranasal Formulations for Use in Equines

International Journal of Equine Science, 2022
The aim of this review is to assess penetration enhancers, such as cyclodextrins, chitosan and their derivatives, surfactants, bile acids, their salts and derivatives, sodium taurodihidrydrofusidate, and phospholipids used in the development of ...
María Inés Velloso, Fabiana Landoni
doaj  

FSD-C10, a Fasudil derivative, promotes neuroregeneration through indirect and direct mechanisms. [PDF]

, 2017
FSD-C10, a Fasudil derivative, was shown to reduce severity of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), through the modulation of the immune response and induction of neuroprotective molecules in the ...
Chai, Zhi, Li, Xing, Li, Yan-Hua, Ma, Cun-Gen, Thome, Rodolfo, Wang, Qing, Xiao, Bao-Guo, Xie, Chong, Zhang, Guang-Xian, Zhang, Hai-Fei, Zhang, Yuan   +10 more
core   +2 more sources

Intranasal administration of gentamicin in human subjects [PDF]

Antimicrobial Agents and Chemotherapy, 1983
The effectiveness of gentamicin administered by the intranasal route in healthy human volunteers was studied. Thirty minutes after gentamicin in a solution of 1% sodium glycocholate was administered at 2 mg/kg of body weight, gentamicin concentrations of 2.48 +/- 0.42 mg/ml were present in the sera. Serum concentrations decreased to 0.94 +/- 0.13 mg/ml
openaire   +2 more sources

Biomimetic Ru‐Mn Nanozyme with Cascade Catalytic Activity Attenuates Secondary Brain Injury in Intracerebral Hemorrhage

Advanced Science, EarlyView.
Ru–Mn composite nanozymes are engineered to mimic dual‐enzyme cascade catalysis, enabling efficient ROS clearance and neuroinflammation suppression. In collagenase‐ and autologous blood‐induced ICH mouse models, intranasal and intravenous administration reduced hematoma volume, preserved BBB integrity, and improved neurological recovery.
Zhongxin Duan, Peng Li, Yue Wang, Xin Qi, Wanyu Wang, Yongzhong Cheng, Huabin Zhang, Xin Hu, Xiang Gao   +8 more
wiley   +1 more source