Results 71 to 80 of about 65,444 (303)

Comparison of intranasal administration of diazepam,

The Iranian Journal of Veterinary Science and Technology, 2009
Safe and effective sedation methods are as much important for small pet birds as for the other animals not only for surgical procedures but also for safe handling and diagnostic and clinical procedures such as radiography, wound dressing, blood collection, endoscopy and fracture repair procedures.
Zamani Moghadam, Abdolkarim, Bigham Sadegh, Amin, Sharifi, Siavash, Habibian, Saeid   +3 more
openaire   +2 more sources

Effect of Repeated Intranasal Administration of Different Doses of Insulin on Postoperative Delirium, Serum τ and Aβ Protein in Elderly Patients Undergoing Radical Esophageal Cancer Surgery

, 2023
Qingqing Huang,1 Qin Shi,2 Xiaobo Yi,1 Jingzheng Zeng,2 Xuemei Dai,1 Lu Lin,1 Yanling Yang,1 Xiao Wu,2 Gu Gong1 1Department of Anesthesiology, The General Hospital of Western Theater Command, Chengdu, People’s Republic of China; 2Department of ...
Yi X, Yang Y, Shi Q, Zeng J, Huang Q, Lin L, Dai X, Wu X, Gong G   +8 more
core  

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Intranasal Drug Administration for Psychomotor Agitation as a Safe and Effective Prehospital Intervention: An Integrative Review [PDF]

Introduction: Psychomotor agitation represents a complex medical emergency, particularly challenging in prehospital settings. Since March 2020, the incidence of psychomotor agitation has significantly increased. Rationale: Emergency Medical Services (EMS)
Noelia Navas-Echazarreta, Quintana-Diaz, Manuel [0000-0003-4852-4148], Maria Peinado-Quesada, Juárez-Vela, Raúl [0000-0003-3597-2048], Marta Giménez-Luzuriaga, García-Criado, Jorge, Rodríguez-Calvo, Antonio [0000-0002-3185-4805], Raúl Juárez-Vela, Manuel Quintana-Diaz, Navas-Echazarreta, Noelia, Amaya Burgos-Esteban, Burgos-Esteban, Amaya, Antonio Rodríguez-Calvo, Pablo Lasa-Berasain, Giménez-Luzuriaga, Marta, Michal Czapla, Lasa-Berasain, Pablo, Peinado-Quesada, Maria, Czapla, Michal [0000-0002-4245-5420], Laura Gómez-Lage, Valvanera Cordón-Hurtado, Cordón-Hurtado, Valvanera, Jorge García-Criado, Gómez-Lage, Laura   +23 more
core   +1 more source

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, EarlyView.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

Perspectives on intranasal administration of corticosteroids

, 2023
Intranasal administration of corticosteroids: patients, administration techniques and instructionsIntranasal corticosteroids (INCs) are used in allergic rhinitis and suppress allergic inflammation in the nasal mucosa. Adequate administration of INCs has received limited attention in clinical practice and scientific literature, whilst research about ...
openaire   +2 more sources

Pharmacokinetic analysis of dantrolene in plasma and brain after oral and intranasal administration.

, 2020
A. The peak dantrolene plasma concentration (Cmax) occurred at 20 minutes after intranasal administration (5mg/kg) and at 50 minutes after oral administration (5mg/kg).
Yun Shi (172065), Huafeng Wei (333273), Shuchun Yu (782080), Yan Wang (15435), Qingcheng Meng (8561451), Ge Liang (578601), Jintao Wang (8051), Maryellen F. Eckenhoff (8561454)   +7 more
core   +1 more source

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu, Yin Dou, Chenwen Li, Yuying Mu, Huiying Ouyang, Wenhao Shen, Jianxiang Zhang   +6 more
wiley   +1 more source