Results 41 to 50 of about 74,961 (259)

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

open access: yesAdvanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li   +8 more
wiley   +1 more source

CHRONIC NASAL HYPER-REACTIVITY (CURRENT CLASSIFICATIONS, CLINICAL PATTERN, DIAGNOSIS)

open access: yesМедицинский совет, 2017
Nasal hyper-reactivity (NG) is a clinical phenomenon manifested by increased individual sensitivity of the nasal mucosa to factors that do not cause symptoms in healthy people.
E. P. MERKULOVA, S. N. KOLESNIKOVA
doaj   +1 more source

Cytokines, Proliferation Markers, Antimicrobial Factors and Neuropeptide-Containing Innervation in Human Nasal Mucosa after Rhinoseptoplasty Procedure

open access: yesMedical Sciences, 2021
The nasal cavity lined by nasal mucosa, is a significant part of respiratory system of human. However, there are no studies aimed to detect a molecular phenotype of healthy and normal functioning nasal mucosa, obtained after rhinoseptoplasty procedure ...
Marija Podlesnaja   +2 more
doaj   +1 more source

Malignant melanoma of the nasal mucosa

open access: yesIndian Journal of Otolaryngology and Head and Neck Surgery, 1999
Malignant melanoma of the nasal mucosa is a rare tumor. We present here a case which involved the nose and the paranasal sinuses. Though surgical excision was achieved, postoperative metastalic spread to the liver resulted in poor prognosis, necessitating chemotherapy. Relevant literature on the subject is reviewed.
A, Ravikumar, V, Gupta
openaire   +3 more sources

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

open access: yesAdvanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib   +8 more
wiley   +1 more source

Intranasal Delivery of a Chitosan-Hydrogel Vaccine Generates Nasal Tissue Resident Memory CD8+ T Cells That Are Protective against Influenza Virus Infection

open access: yesVaccines, 2020
Rapid antigen clearance from the nasal mucosa is one of the major challenges in the development of intranasal vaccines. Here, we tested whether intranasal immunization with a chitosan-hydrogel vaccine, with in situ gelling properties, extended antigen ...
James G. Bedford   +2 more
doaj   +1 more source

Ultrastructure of human nasal mucosa [PDF]

open access: yesThe Laryngoscope, 1983
AbstractThis thesis describes the ultrastructure of human nasal mucosa, based upon surgical biopsy specimens. The intent of the study is to characterize the normal ultrastructure of human nasal mucosa with emphasis upon the difference between olfactory and respiratory epithelia.
openaire   +2 more sources

CauFinder: Steering Cell‐State and Phenotype Transitions by Causal Disentanglement Learning

open access: yesAdvanced Science, EarlyView.
CauFinder combines causal disentanglement modeling and network control to prioritize causal drivers of cell‐state transitions from observational transcriptomic data. The framework separates transition‐relevant signals from spurious associations, nominates intervention targets across biological and disease contexts, and identifies DAAM1 as an actionable
Chengming Zhang   +11 more
wiley   +1 more source

TGF-β Signaling May Play a Role in the Development of Goblet Cell Hyperplasia in a Mouse Model of Allergic Rhinitis

open access: yesAllergology International, 2010
: Background: Transforming growth factor-p (TGF-β) levels are elevated in the nasal mucosa in allergic rhinitis. However, because TGF-β is secreted extracellulary in latent complexes, it remains unclear whether the local TGF-β expression actually drives
Yuhui Ouyang   +8 more
doaj   +1 more source

Nonylphenol exacerbates ovalbumin-induced allergic rhinitis via the TSLP-TSLPR/IL-7R pathway and JAK1/2-STAT3 signaling in a mouse model

open access: yesEcotoxicology and Environmental Safety, 2022
Nonylphenol (NP) can be widely used as a plasticizer, surfactant, antioxidant, textile printing, dyeing additive, and pesticide emulsifier. Animal studies have shown that NP aggravates ovalbumin (OVA)-induced allergic rhinitis (AR); however, the exact ...
Yunxiu Wang   +3 more
doaj   +1 more source

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