Results 21 to 30 of about 153,361 (353)

Aminopeptidase activity in human nasal mucosa [PDF]

Journal of Allergy and Clinical Immunology, 1998
Aminopeptidases activate bradykinin and degrade many inflammatory peptides.The objective of this study was to identify the types of aminopeptidase activities in human nasal mucosa.Human nasal mucosa was homogenized (n = 12), and cytoplasmic (S2) and membrane-rich (P2) fractions were obtained.
Ohkubo, Kimihiro, Baraniuk, James N., Hohman, Robert, Merida, Marco, Hersh, Louis B., Kaliner, Michael A.   +5 more
openaire   +2 more sources

A Novel Approach for Investigating Upper Airway Hyperresponsiveness Using Micro-CT in Eosinophilic Upper Airway Inflammation such as Allergic Rhinitis Model

Biomolecules, 2019
Airway hyperresponsiveness (AHR) has been proposed as a feature of pathogenesis of eosinophilic upper airway inflammation such as allergic rhinitis (AR). The measurement system for upper AHR (UAHR) in rodents is poorly developed, although measurements of
Dan Van Bui, Akira Kanda, Yoshiki Kobayashi, Yoshiko Sakata, Yumiko Kono, Yoshiyuki Kamakura, Takao Jinno, Yasutaka Yun, Kensuke Suzuki, Shunsuke Sawada, Mikiya Asako, Akihiko Nakamura, David Dombrowicz, Keita Utsunomiya, Tanigawa Noboru, Koichi Tomoda, Hiroshi Iwai   +16 more
doaj   +1 more source

Effect of Biospray Dressings on Eosinophil Infiltration in the Nasal Mucosa and Serum IgE Levels After Nasal Provocation in Experimental Allergic Rhinitis

Allergy & Rhinology, 2020
Purpose To investigate the effect of biospray dressing on the extent of eosinophil infiltration in the nasal mucosa and the level of serum IgE in experimental allergic rhinitis with nasal provocation.
Shan Huang BSc, Geping Wu MD, PhD, Xiaodan Gu BSM, Hongyan Zhu MD, Xingkai Ma BSM, Yifang Yuan BSM, Yan Lv MD, Di Li MD, Ling Zhang MD   +8 more
doaj   +1 more source

Herpes simplex virus type 1 infection facilitates invasion of Staphylococcus aureus into the nasal mucosa and nasal polyp tissue. [PDF]

PLoS ONE, 2012
BACKGROUND: Staphylococcus aureus (S. aureus) plays an important role in the pathogenesis of severe chronic airway disease, such as nasal polyps. However the mechanisms underlying the initiation of damage and/or invasion of the nasal mucosa by S.
XiangDong Wang, Nan Zhang, Sarah Glorieux, Gabriele Holtappels, Mario Vaneechoutte, Olga Krysko, Luo Zhang, Demin Han, Hans J Nauwynck, Claus Bachert   +9 more
doaj   +1 more source

The nasal symbiont Staphylococcus species restricts the transcription of SARS-CoV-2 entry factors in human nasal epithelium

iScience, 2021
Summary: Emerging evidence indicates that severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) is transmitted through the human nasal mucosa via the principal entry factors angiotensin-converting enzyme 2 (ACE2) and transmembrane serine ...
Jeong-Yeon Ji, Ara Jo, Jina Won, Chan Hee Gil, Haeun Shin, Sujin Kim, Yung Jin Jeon, Hyun Jik Kim   +7 more
doaj   +1 more source

Histological markers in nasal mucosa of patients with Alzheimer's disease [PDF]

, 1998
Neuropathological changes such as dystrophic neurites and the presence of abnormal tau protein in the olfactory system, including primary sensory cells and nerve fibres have previously been demonstrated in nasal mucosa tissue of patients with Alzheimer's
Golombowski, Sidonie, Hock, Christoph, Mandelkow, Eva-Maria, Müller-Spahn, Franz, Peschel, Oliver, Probst, Alphonse, Riederer, Andreas, Unger, Jürgen   +7 more
core   +1 more source

RETRACTED ARTICLE: MicroRNA-29 mediates anti-inflammatory effects and alleviation of allergic responses and symptoms in mice with allergic rhinitis

Allergy, Asthma & Clinical Immunology, 2021
Background To investigate the role of microRNA-29 (miR-29) in mice with allergic rhinitis (AR) and its underlying mechanism. Methods AR model was established in BALB/c mice by intraperitoneal sensitization and intranasal challenge with ovalbumin (OVA ...
Jia Wang, Jinshu Yin, Hong Peng, Aizhu Liu   +3 more
doaj   +1 more source

Peroxisome Proliferator-Activated Receptor γ Negatively Regulates Allergic Rhinitis in Mice

Allergology International, 2009
Background: Peroxisome proliferator-activated receptor γ (PPAR-γ) has been shown to play an important role in the control of inflammatory responses acting on macrophages, mast cells, T cells, and eosinophils.
Naoko Fukui, Kohei Honda, Eiko Ito, Kazuo Ishikawa   +3 more
doaj   +1 more source

Nasal Drug Delivery Systems: An Overview [PDF]

, 2015
Since ancient times, drugs have been administered via the nasal route for therapeutic and recreational purposes. The interest in, and importance, of the systemic effects of drugs administered through the nasal route, have expanded over recent decades ...
Conway, Barbara R., Ghori, Muhammad U., Mahdi, Mohammed H., Smith, Alan M.   +3 more
core   +1 more source

Nasal symbiont Staphylococcus epidermidis restricts the cellular entry of influenza virus into the nasal epithelium

npj Biofilms and Microbiomes, 2022
Our recent study presented that human nasal commensal Staphylococcus epidermidis could potentiate antiviral immunity in the nasal mucosa through interferon-related innate responses. Here, we found that human nasal commensal S.
Ara Jo, Jina Won, Chan Hee Gil, Su Keun Kim, Kang-Mu Lee, Sang Sun Yoon, Hyun Jik Kim   +6 more
doaj   +1 more source