Results 51 to 60 of about 688,047 (369)

Nasal Delivery of High Molecular Weight Drugs

Molecules, 2009
Nasal drug delivery may be used for either local or systemic effects. Low molecular weight drugs with are rapidly absorbed through nasal mucosa. The main reasons for this are the high permeability, fairly wide absorption area, porous and thin endothelial
Erdal Cevher, Yıldız Ozsoy, Sevgi Gungor   +2 more
doaj   +1 more source

Interleukin-22 regulates antimicrobial peptide expression and keratinocyte differentiation to control Staphylococcus aureus colonization of the nasal mucosa

Mucosal Immunology, 2016
The local immune response occurring during Staphylococcus aureus nasal colonization remains ill-defined. Studies have highlighted the importance of T-cell immunity in controlling S. aureus colonization of the nasal mucosa.
ME Mulcahy, JM Leech, J. Renauld, Khg Mills, RM McLoughlin   +4 more
semanticscholar   +1 more source

ROLE OF ANATOMICAL OBSTRUCTION IN THE PATHOGENESIS OF CHRONIC SINUSITIS [PDF]

, 2012
Sinusitis is a commonly diagnosed condition in the general population.This article is a study to asses the role of anatomical obstruction in the pathogenesis of chronic sinusitis,based on symptomatology and radiological findings of the patients.The ...
Basith, Yahia Abdul, Thiagarajan, Balasubramanian   +1 more
core   +2 more sources

Symbiotic microbiome Staphylococcus epidermidis restricts IL-33 production in allergic nasal epithelium via limiting the cellular necroptosis

BMC Microbiology, 2023
Background Allergic rhinitis (AR) is characterized by airway inflammation in nasal mucosa from inhaled allergens and interleukin (IL)-33 is the potent inducer of Th2 inflammation in allergic nasal epithelium. Staphylococcus epidermidis is one of the most
Yung Jin Jeon, Chan Hee Gil, Jina Won, Ara Jo, Hyun Jik Kim   +4 more
doaj   +1 more source

Relative vascular permeability and vascularity across different regions of the rat nasal mucosa: implications for nasal physiology and drug delivery

Scientific Reports, 2016
Intranasal administration provides a non-invasive drug delivery route that has been proposed to target macromolecules either to the brain via direct extracellular cranial nerve-associated pathways or to the periphery via absorption into the systemic ...
Niyanta N. Kumar, Mohan Gautam, Jeffrey J. Lochhead, Daniel J. Wolak, V. Ithapu, Vikas Singh, R. Thorne   +6 more
semanticscholar   +1 more source

Operation Nasal Vaccine—Lightning speed to counter COVID-19

Science immunology, 2022
Given the poor ability of intramuscular mRNA COVID-19 vaccines to induce robust immunity in the respiratory mucosa, a push for a nasal vaccine strategy is needed.
E. Topol, A. Iwasaki
semanticscholar   +1 more source

Different Methods and Formulations of Drugs and Vaccines for Nasal Administration

Pharmaceutics, 2022
Nasal drug delivery is advantageous when compared with other routes of drug delivery as it avoids the hepatic first-pass effect, blood–brain barrier penetration, and compliance issues with parenteral administration. However, nasal administration also has
Junhu Tai, M. Han, Dabin Lee, I. Park, Sang Hag Lee, Tae Hoon Kim   +5 more
semanticscholar   +1 more source

Comparing the immune response to a novel intranasal nanoparticle PLGA vaccine and a commercial BPI3V vaccine in dairy calves [PDF]

, 2015
peer-reviewedBackground There is a need to improve vaccination against respiratory pathogens in calves by stimulation of local immunity at the site of pathogen entry at an early stage in life. Ideally such a vaccine preparation would not be inhibited by
A Menanteau-Horta, A Vila, AR Peters, B Morein, B Morein, Bernadette Earley, BJF Bradshaw, BM Adair, Bryan Markey, C Pilette, CA Siegrist, CX Song, DG Bryson, DP Greenberg, EM Liebler-Tenorio, F Alexis, F Mansoor, Fawad Mansoor, FM Buonaguro, HM Chen, I Vangeel, J Phillips, J Pollock, JE Crowe, Joseph P. Cassidy, JS Salt, K Tahara, KJ Wiechelman, M Garinot, M Higaki, Michael D. Welsh, ML Hans, MS Lee, OV Kavanagh, PE Shewen, PK Smith, PR Wood, RE Brown, RM Zinkernagel, S Lofthouse, Simon Doherty, TG Kimman, YJ Kwon   +42 more
core   +1 more source

Cold bubble humidification of low-flow oxygen does not prevent acute changes in inflammation and oxidative stress at nasal mucosa

Scientific Reports, 2021
Some clinical situations require the use of oxygen therapy for a few hours without hypoxemia. However, there are no literature reports on the effects of acute oxygen therapy on the nasal mucosa.
Lauriana Alves Santana, Suellen Karoline Moreira Bezerra, Beatriz Mangueira Saraiva-Romanholo, Wellington Pereira Yamaguti, Iolanda de Fátima Lopes Calvo Tibério, Tabata Maruyama dos Santos, Renato Fraga Righetti   +6 more
doaj   +1 more source

Structure and Fate of Nanoparticles Designed for the Nasal Delivery of Poorly Soluble Drugs.

Molecular Pharmaceutics, 2021
Nanoparticles are promising mediators to enable nasal systemic and brain delivery of active compounds. However, the possibility of reaching therapeutically relevant levels of exogenous molecules in the body is strongly reliant on the ability of the ...
A. Clementino, G. Pellegrini, Sabrina Banella, G. Colombo, L. Cantu', F. Sonvico, E. Del Favero   +6 more
semanticscholar   +1 more source