Results 1 to 10 of about 347,117 (151)

Real-Life Effects of Omalizumab on Chronic Rhinosinusitis with Nasal Polyposis. [PDF]

J Pers Med, 2023
Chronic rhinosinusitis with nasal polyposis (CRSwNP) is an inflammatory disease of the nasal and sinus mucosa. This inflammatory process is supported by a multitude of cytokines, including IL-4, IL-5, and IL-13 produced by Th2 cells, as well as by IgE ...
Lombardo N, Piazzetta GL, Lobello N, Cicala G, Patafi M, Benincasa AT, Pelaia C, Chiarella E, Pelaia G.   +8 more
europepmc   +2 more sources

Pathobiology of Type 2 Inflammation in Asthma and Nasal Polyposis. [PDF]

J Clin Med, 2023
Asthma and nasal polyposis often coexist and are frequently intertwined by tight pathogenic links, mainly consisting of the cellular and molecular pathways underpinning type 2 airway inflammation.
Pelaia C, Pelaia G, Maglio A, Tinello C, Gallelli L, Lombardo N, Terracciano R, Vatrella A.   +7 more
europepmc   +2 more sources

Pathogenesis of Nasal Polyposis: Current Trends. [PDF]

Indian J Otolaryngol Head Neck Surg, 2023
Chronic Rhinosinusitis (CRS) is characterized by edema of the sub-epithelial layers, but, only specific types of CRS are developing polyps. Nasal polyposis may develop under different pathogenetic mechanisms rendering the typical macroscopic ...
Goulioumis AK, Kourelis K, Gkorpa M, Danielides V.   +3 more
europepmc   +2 more sources

Management of Chronic Rhinosinusitis With Nasal Polyposis in the Era of Biologics

Journal of Asthma and Allergy, 2021
Purpose of Review Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a phenotypic designation of the broader condition of chronic rhinosinusitis. The advent of targeted biologics has shown promise in targeting different aspects of the inflammatory ...
Brent Senior, Justin Morse
exaly   +2 more sources

ARIA-ITALY multidisciplinary consensus on nasal polyposis and biological treatments

World Allergy Organization Journal, 2021
In the recent years, it was recognized that type-2 inflammation links many forms of nasal polyposis with severe asthma. Thus, some biological drugs developed for severe asthma appeared to exert an effect on nasal polyposis.
Carlo Lombardi, MD, Riccardo Asero, MD, Diego Bagnasco, MD, Francesco Blasi, MD, Matteo Bonini, MD, Mario Bussi, MD, Rikki F. Canevari, MD, Giorgio Walter Canonica, MD, Paolo Castelnuovo, MD, Lorenzo Cecchi, MD, Lorenzo Cosmi, MD, Matteo Gelardi, MD, Enrico Heffler, MD, Luciana Indinnimeo, MD, Massimo Landi, MD, Amelia Licari, MD, Francesco Liotta, MD, Alberto Macchi, MD, Luca Malvezzi, MD, Gianluigi Marseglia, MD, Claudio Micheletto, MD, Antonino Musarra, MD, Diego Peroni, MD, Giorgio Piacentini, MD, Venerino Poletti, MD, Luca Richeldi, MD, Angela Santoni, MD, Michele Schiappoli, MD, Gianenrico Senna, MD, Adriano Vaghi, MD, Alberto Villani, MD, Giovanni Passalacqua, MD   +31 more
doaj   +2 more sources

The PI3K-Akt-HIF-1α Pathway Reducing Nasal Airway Inflammation and Remodeling in Nasal Polyposis

Ear, Nose & Throat Journal, 2021
Objective: Previous studies suggested that hypoxia-inducible factor-1α (HIF-1α) plays an important role in the progression of inflammation and remodeling of chronic rhinosinusitis with nasal polyposis.
Fei He MD, Huaigang Liu MD, Wei Luo MD
doaj   +2 more sources

ARIA-Italy multidisciplinary consensus on nasal polyposis and biological treatments: Update 2025 [PDF]

World Allergy Organization Journal
In recent years, it was recognized that type-2 inflammation connects nasal polyposis and severe asthma (SA) in addition to other type-2 diseases. Thus, some biological drugs developed for SA appeared to exert a favourable effect also in nasal polyposis ...
Carlo Lombardi, MD, Rikki F. Canevari, MD, Diego Bagnasco, MD, Maria Beatrice Bilò, MD, Giorgio Walter Canonica, MD, Cristiano Caruso, MD, Paolo Castelnuovo, MD, Lorenzo Cecchi, MD, Orietta Calcinoni, MD, Mauro Carone, MD, Marco Cassatella, MD, Renato Cutrera, MD, Gianni Danesi, MD, Eugenio De Corso, MD, Mario Di Gioacchino, MD, Fabiano Di Marco, MD, Stefania Gallo, MD, Matteo Gelardi, MD, Enrico Heffler, MD, Clara Imperatore, MD, Cristiana Indolfi, MD, Massimo Landi, MD, Amelia Licari, MD, Francesco Liotta, MD, Alberto Macchi, MD, Luca Malvezzi, MD, Sara Manti, MD, Francesco Menzella, MD, Claudio Micheletto, MD, Fabio Midulla, MD, Michele Miraglia Del Giudice, MD, Antonino Musarra, MD, Vincenzo Patella, MD, Diego Peroni, MD, Laura Petrarca, MD, Giorgio Piacentini, MD, Alessandro Pusateri, MD, Veronica Seccia, MD, PhD, Gianenrico Senna, MD, Adriano Vaghi, MD, Carlo Vancheri, PhD, Giovanni Passalacqua, MD, S. Arasi, D. Bagnasco, I. Baiardini, S. Barbaglia, F. Barosso, R. Bernardini, A. Berti, B. Bilò, L. Brussino, F.R. Canevari, G.W. Canonica, C. Caruso, A.A. Caruso, A.G. Caviglia, L. Cecchi, P. Comberiati, L. Cosmi, M. Cottini, M. Crivellaro, D. Di Bona, A. Fiocchi, S. Frateiacci, M. Gelardi, G. Guida, E. Heffler, C. Incorvaia, M. Landi, M.A. Licari, L. Malvezzi, M. Milanese, F. Mina, E. Nettis, G. Pala, V. Patella, D. Peroni, S. Peveri, F. Puggioni, A. Pusateri, O. Rossi, E. Ridolo, E. Savi, J. Schroeder, V. Seccia, G.E. Senna, M. Triggiani, M. Uberti, G. Varricchi, M.T. Ventura, M.T. Zedda   +90 more
doaj   +2 more sources

Dupilumab Reduces Local Type 2 Pro-Inflammatory Biomarkers in Chronic Rhinosinusitis With Nasal Polyposis

Allergy: European Journal of Allergy and Clinical Immunology, 2019
Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a type 2‐mediated inflammatory disease associated with significant clinical, social, and economic burdens and high unmet therapeutic need.
Gianluca Pirozzi, Karin Jonstam, Lars Olaf Cardell   +2 more
exaly   +2 more sources

High PI3K/mTOR and low MAPK/JNK activity results in decreased apoptosis and autophagy in nasal polyposis

Brazilian Journal of Otorhinolaryngology, 2021
Introduction: Nasal polyposis is a progressive inflammatory disease that reduces the quality of life. The role of apoptotic and autophagic pathways in nasal polyposis pathogenesis is not yet clearly known. Objective: In this study we aimed to investigate
Fatma Simsek, Erdem Eren, Selen Bahceci, Ibrahim Aladag   +3 more
doaj   +1 more source

European Academy of Allergy and Clinical Immunology position paper on endoscopic scoring of nasal polyposis

Allergy. European Journal of Allergy and Clinical Immunology, 2023
Nasal endoscopy is not only used for the diagnosis of chronic rhinosinusitis with nasal polyps (CRSwNP), but also for monitoring the response to therapy playing an important role in both daily practice and research.
P. Gevaert, Jarno De Craemer, C. Bachert, M. Blauwblomme, A. Chaker, C. Cingi, P. Hellings, C. Hopkins, V. Hox, W. Fokkens, L. Klimek, V. Lund, R. Mösges, J. Mullol, O. Pfaar, G. Scadding, P. Tomazic, T. van Zele, S. Vlaminck, M. Wagenmann, S. Toppila-Salmi, I. Alobid   +21 more
semanticscholar   +1 more source