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Which Is the Best Biologic for Nasal Polyps: Dupilumab, Omalizumab, or Mepolizumab? A Network Meta-Analysis

International Archives of Allergy and Immunology, 2021
Introduction: Compared with the placebo, biologics are beneficial in reducing nasal polyp mass and safe in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). However, there lacks a head-to-head randomized trial comparing biologics. We aimed
Qingwu Wu   +8 more
semanticscholar   +1 more source

Benralizumab effect on severe chronic rhinosinusitis with nasal polyps (CRSwNP): A randomized double‐blind placebo‐controlled trial

Clinical and Experimental Allergy, 2021
Chronic rhinosinusitis with nasal polyps (CRSwNP) can be a severe and debilitating disease associated with significant morbidity, loss of smell, sinus pressure and asthma exacerbations.
J. Tversky, A. Lane, A. Azar
semanticscholar   +1 more source

Single-cell analysis pinpoints distinct populations of cytotoxic CD4+ T cells and an IL-10+CD109+ TH2 cell population in nasal polyps

Science immunology, 2021
Transcriptional profiling pinpoints the heterogeneity of T helper cells in human nasal polyps at the clonal level. Who nose the T cell subsets in nasal polyps?
Junjie Ma   +7 more
semanticscholar   +1 more source

Economic Evaluation of Dupilumab Versus Endoscopic Sinus Surgery for the Treatment of Chronic Rhinosinusitis With Nasal Polyps

International Forum of Allergy and Rhinology, 2021
Dupilumab is a novel monoclonal antibody that recently received US Food and Drug Administration approval for the treatment of chronic rhinosinusitis with nasal polyps.
A. Parasher   +5 more
semanticscholar   +1 more source

Cost Utility Analysis of Dupilumab Versus Endoscopic Sinus Surgery for Chronic Rhinosinusitis With Nasal Polyps

The Laryngoscope, 2020
Both endoscopic sinus surgery (ESS) and biologic therapies have shown effectiveness for medically‐refractory chronic rhinosinusitis with nasal polyps (CRSwNP) without severe asthma. The objective was to evaluate cost‐effectiveness of dupilumab versus ESS
George A Scangas   +6 more
semanticscholar   +1 more source

Central compartment atopic disease: outcomes compared with other subtypes of chronic rhinosinusitis with nasal polyps

International Forum of Allergy and Rhinology, 2021
Central compartment atopic disease (CCAD) is a variant of chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) characterized by polypoid changes of the superior nasal septum, middle (MT), and/or superior turbinates (ST).
Andrew J. Steehler   +3 more
semanticscholar   +1 more source

Outcomes of dupilumab treatment versus endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps

International Forum of Allergy and Rhinology, 2021
Outside of SINUS‐24 (A Controlled Clinical Study of Dupilumab in Patients With Bilateral Nasal Polyps) and SINUS‐52 (Controlled Clinical Study of Dupilumab in Patients With Nasal Polyps), there are limited data on the efficacy of dupilumab in patients ...
Harish Dharmarajan   +3 more
semanticscholar   +1 more source

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