Results 61 to 70 of about 22,731 (179)

Preclinical signal for a disease‐modifying effect on seizure cluster severity with intermittent diazepam treatment

Epilepsia, EarlyView.
Abstract Objective In epilepsy, daily treatment provides only symptomatic seizure control, leaving a significant unmet need for a treatment that affects the underlying predisposition to seizures. Here, in a first‐of‐its‐kind study, we test the hypothesis that intermittent treatment of seizure clusters with diazepam in the kainic acid post‐status ...
Qian Wu, Michelle Guignet, Jonathan Vuong, H. Steve White, Wesley T. Kerr, Evelyn K. Shih, Leock Y. Ngo, Enrique Carrazana, Adrian L. Rabinowicz   +8 more
wiley   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

The Burden of Disease of Treatment‐Seeking Patients With a Cluster‐C Personality Disorder in the Netherlands; Quality of Life, Functioning, and Societal Costs

Journal of Clinical Psychology, EarlyView.
ABSTRACT Cluster‐C personality disorders (PDs) are common in the general population but often overlooked in scientific research and clinical practice. An important step to increase awareness for timely diagnosis and treatment of cluster‐C PDs is to investigate the burden of disease in terms of quality of life (QoL), daily functioning and the associated
Iuno Z. Groot, Arnoud Arntz, Carlijn J. M. Wibbelink, Bas Verhoeven, Nathan R. Bachrach, Silvia M. A. A. Evers   +5 more
wiley   +1 more source

How I Do It: The Transtracheal Approach for Awake Cricopharyngeal Botulinum Toxin Injection

The Laryngoscope, EarlyView.
This transtracheal technique for cricopharyngeal botulinum toxin injection is a safe and effective option for chemodenervation of this muscle in the awake patient. Its advantages include reduced risk of toxin spread to intrinsic laryngeal muscles, the ability to administer higher doses of botulinum toxin, improved access to the entire length of the ...
Andrew Tritter, Alexander Simko, Karim Asi   +2 more
wiley   +1 more source

The Comparison of Nasaleze and Mometasone Nasal Spray to Control the Symptoms of Allergic Rhinitis

Advanced Biomedical Research, 2018
Background: Nasal corticosteroids are the main drug class for the treatment of allergic rhinitis, and their long-term continuous use can be problematic.
Nafiseh Sadat Mahmoodi, Seyyed Ahmad Reza Okhovat, Seyyed Hamid Reza Abtahi, Amirhossein Moslehi   +3 more
doaj   +1 more source

Diagnosing Eosinophilic Chronic Rhinosinusitis in Excised Tissue Using Optical Coherence Tomography

The Laryngoscope, EarlyView.
This study evaluated whether optical coherence tomography (OCT) can quantify eosinophils in excised sinonasal tissue and diagnose eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP). Counts of globules resembling eosinophils on OCT images strongly correlated with eosinophils per HPF on histology, with a cutoff of 45 globules on OCT imaging ...
Ido Badash, Michael Serafino, Adrian Correa, John S. Oghalai, Bozena Wrobel, Brian E. Applegate, Kevin Hur   +6 more
wiley   +1 more source

Olfactory Bulb Volume and Function Recovery in Eosinophilic Chronic Rhinosinusitis

The Laryngoscope, EarlyView.
This study investigated perioperative changes in olfactory bulb volume (OBV) in patients with eosinophilic chronic rhinosinusitis using high‐resolution 3T MRI. Postoperative increases in OBV were associated with improvements in olfactory identification, suggesting a potential link between olfactory bulb structural plasticity and functional recovery ...
Keisuke Yamamoto, Masaki Abukawa, Tsuyoshi Okuni, Mitsuhiro Nakanishi, Yuki Sakurai, Naoya Yama, Noriko Ogasawara, Ryuta Kamekura, Kenichi Takano   +8 more
wiley   +1 more source

Visualization of nasal powder distribution using biomimetic human nasal cavity model

Acta Pharmaceutica Sinica B
Nasal drug delivery efficiency is highly dependent on the position in which the drug is deposited in the nasal cavity. However, no reliable method is currently available to assess its impact on delivery performance.
Jiawen Su, Yan Liu, Hongyu Sun, Abid Naeem, Huipeng Xu, Yue Qu, Caifen Wang, Zeru Li, Jianhua Lu, Lulu Wang, Xiaofeng Wang, Jie Wu, Lixin Sun, Jiwen Zhang, Zhigang Wang, Rui Yang, Li Wu   +16 more
doaj   +1 more source

A herbal composition of Scutellaria baicalensis and Eleutherococcus senticosus shows vasocontrictive effects in an ex-vivo mucosal tissue model and in allergic rhinitis patients

Clinical Phytoscience, 2017
Background This study aimed to investigate the nasal decongestive efficacy of an alternative to pharmacotherapy, a herbal nasal spray composed of Scutellaria baicalensis and Eleutherococcus senticosus.
Michael Katotomichelakis, K. Van Crombruggen, G. Holtappels, F. A. Kuhn, C. E. Fichandler, C. A. Kuhn-Glendye, J. B. Anon, C. T. Melroy, B. Karanfilov, T. W. Haegen, I. Kastanioudakis, C. Bachert, N. Zhang   +12 more
doaj   +1 more source

Traditional Chinese Medicine as an Integrative Adjunct in Oncology Perioperative Practice: Analgesia, Immune Modulation, and Translational Challenges

Medicine Bulletin, EarlyView.
ABSTRACT Traditional Chinese medicine (TCM), including herbal analgesic adjuvants and acupuncture‐based interventions, has gained increasing attention as an integrative strategy for perioperative pain management in oncology. Bioactive phytochemicals—such as terpenoids, flavonoids, alkaloids, and polyphenols—exert multimodal pharmacological effects ...
Yuqin Tang, Zheng Luo, Xu Zhao, Yongqiang Zhang, Mingyang Sun, Jiaqiang Zhang   +5 more
wiley   +1 more source