Results 41 to 50 of about 60,978 (331)

Cluster randomised, controlled, triple-blind trial assessing the efficacy of intranasally administered virus-neutralising bovine colostrum supplement in preventing SARS-CoV-2 infection in household contacts of SARS-CoV-2-positive individuals: a study protocol

open access: yesTrials, 2022
The SARS-CoV-2 enters into the human body mainly through the nasal epithelial cells. Prevention of SARS-CoV-2 infection at the point of nasal entry is a novel strategy that has the potential to help contain the ongoing pandemic. BioBlock is a nasal spray
Anneli Uusküla   +4 more
doaj   +1 more source

Liquid Film Translocation Significantly Enhances Nasal Spray Delivery to Olfactory Region: A Numerical Simulation Study

open access: yesPharmaceutics, 2021
Previous in vivo and ex vivo studies have tested nasal sprays with varying head positions to enhance the olfactory delivery; however, such studies often suffered from a lack of quantitative dosimetry in the target region, which relied on the observer’s ...
Xiuhua April Si   +2 more
doaj   +1 more source

Smart Face Masks as Wearable Respiratory Sensors: A Review of Sensor Technologies, Materials, and Future Directions

open access: yesAdvanced Healthcare Materials, EarlyView.
This review highlights recent advances in smart face masks that actively monitor breathing. By integrating humidity, gas, temperature, pressure, strain, and triboelectric sensors, these masks track key respiratory parameters in real time. The article summarizes sensor mechanisms, compares performance across studies, and discusses challenges and future ...
Negin Faramarzi   +7 more
wiley   +1 more source

In Vitro Ciliotoxicity and Cytotoxicity Testing of Repeated Chronic Exposure to Topical Nasal Formulations for Safety Studies

open access: yesPharmaceutics, 2021
Certain active drugs and excipients of nasal formulations may impair ciliary function and mucociliary clearance. The ciliary beat frequency (CBF) is a key parameter for determining mucociliary clearance rate, and in vitro assessments of CBF have proven ...
Larisa Tratnjek   +3 more
doaj   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

open access: yesAdvanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best   +5 more
wiley   +1 more source

The effect of intranasal steroid in the treatment of allergic rhinitis with and without oral antihistamine (comparative study)

open access: yesAdvanced Medical Journal, 2022
Backgrounds & objectives: Numerous studies have investigated the efficacies of steroid nasal sprays for adults with allergic rhinitis. However, research on their effectiveness in combination with oral antihistamines is limited.
Moyeser Abdulrahman Yaseen   +1 more
doaj   +1 more source

Administration of nasal medications to infants and young children – thematic analysis of parents’ experiences in online forum discussions and blogs [PDF]

open access: yes, 2015
Background: Allergic rhinitis is an increasing problem among children in developed countries. A 12-year birth cohort study from 2001 to 2012 on Isle of Wight showed that current-rhinitis and lifetime-rhinitis prevalence increased by 5.5% (22.6-vs-28.1,
Bulbul, Alpaslan   +3 more
core  

Up to date on the use of triptans for child and adolescent migraine: “the state of the art” [PDF]

open access: yes, 2001
The introduction of triptans, in the early 1990s, has improved the therapy for acute migraine attack, offering a new quality of life for those patients who suffer from this disabling neurological disorder. Epidemiological data point out that about 10% of
D. CALDERONI   +2 more
core   +1 more source

A Super‐Adhesive Air Filter With Capillarity‐Mediated Spontaneous Particle Absorption via Dynamic Bond Exchange

open access: yesAdvanced Materials, EarlyView.
We address the inherently weak particle adhesion of conventional air filters by coating a dynamically crosslinked adhesive layer that delivers capillarity‐driven strong adhesion and particle absorption mediated by dynamic bond exchange. The resulting enhancement in particle adhesion enables efficient ultrafast (up to 20 m s−1) and omnidirectional ...
Junyong Park   +11 more
wiley   +1 more source

Assessing Nasal Epithelial Dynamics: Impact of the Natural Nasal Cycle on Intranasal Spray Deposition

open access: yesPharmaceuticals
This study investigated the intricate dynamics of intranasal spray deposition within nasal models, considering variations in head orientation and stages of the nasal cycle.
Amr Seifelnasr, Xiuhua Si, Jinxiang Xi
doaj   +1 more source

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