Different Methods and Formulations of Drugs and Vaccines for Nasal Administration [PDF]
Pharmaceutics, 2022 Nasal drug delivery is advantageous when compared with other routes of drug delivery as it avoids the hepatic first-pass effect, blood–brain barrier penetration, and compliance issues with parenteral administration. However, nasal administration also has
Junhu Tai +5 more
doaj +2 more sources
Nano-Spray-Dried Levocetirizine Dihydrochloride with Mucoadhesive Carriers and Cyclodextrins for Nasal Administration [PDF]
Pharmaceutics, 2023 Antihistamines such as levocetirizine dihydrochloride (LC) are commercially used in oral tablets and oral drops to reduce allergic symptoms. In this study, LC was nano-spray-dried using three mucoadhesive polymers and four cyclodextrin species to form ...
Mirella Mirankó +4 more
doaj +2 more sources
Development of Nanocomposite Microspheres for Nasal Administration of Deferiprone in Neurodegenerative Disorders [PDF]
Journal of Functional BiomaterialsElevated brain iron levels are characteristic of many neurodegenerative diseases. As an iron chelator with short biological half-life, deferiprone leads to agranulocytosis and neutropenia with a prolonged therapeutic course.
Radka Boyuklieva +5 more
doaj +2 more sources
Physico-Chemical and In Vitro Characterization of Chitosan-Based Microspheres Intended for Nasal Administration [PDF]
Pharmaceutics, 2021 The absorption of non-steroidal anti-inflammatory drugs (NSAIDs) through the nasal epithelium offers an innovative opportunity in the field of pain therapy.
Csilla Bartos +3 more
doaj +2 more sources
Investigation of Nano Spray-Dried, Hyaluronic Acid-Modified Polymeric Micelles for Nasal Administration [PDF]
PharmaceuticsBackground/Objectives: The combination of nanomedicine with nasal administration is of paramount importance in current research and development. Polymeric micelles coated with hyaluronic acid may be a suitable solution to enhance drug release and ...
Bence Sipos +5 more
doaj +2 more sources
Short Onset and Enhanced Analgesia Following Nasal Administration of Non-Controlled Drugs in Nanovesicular Systems [PDF]
Pharmaceutics, 2021 Nasal nanovesicular delivery systems (NVS) containing the noncontrolled analgesic drugs Ketoprofen, Butorphanol or Tramadol, incorporated in a phospholipid nanovesicular carrier, were designed and investigated.
Elka Touitou +3 more
doaj +2 more sources
Enhancement of the immunogenicity of a Mycobacterium tuberculosis fusion protein using ISCOMATRIX and PLUSCOM nano-adjuvants as prophylactic vaccine after nasal administration in mice [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Tuberculosis (TB), a contagious disease caused by Mycobacterium tuberculosis (M. tuberculosis), remains a health problem worldwide and this infection has the highest mortality rate among bacterial infections ...
Arshid Yousefi Avarvand +5 more
doaj +2 more sources
Spray Freeze Dried Lyospheres® for Nasal Administration of Insulin. [PDF]
Pharmaceutics, 2021 Pharmacologically active macromolecules, such as peptides, are still a major challenge in terms of designing a delivery system for their transport across absorption barriers and at the same time provide sufficiently high long-term stability. Spray freeze dried (SFD) lyospheres® are proposed here as an alternative for the preparation of fast dissolving ...
Serim TM +5 more
europepmc +5 more sources
Nasal Administration of a Nanoemulsion Based on Methyl Ferulate and Eugenol Encapsulated in Chitosan Oleate: Uptake Studies in the Central Nervous System [PDF]
PharmaceuticsBackground/Objectives: The phytochemicals ferulic acid (Fer) and eugenol display neuroprotective effects for their anti-oxidative properties; moreover, eugenol can induce dopamine (DA) release from dopaminergic neuronal cells.
Giada Botti +9 more
doaj +2 more sources
Incorporation of Mometasone Furoate into a Cyclodextrin Metal-Organic Framework to Optimize Nasal Administration [PDF]
PharmaceuticsBackground/Objectives: Mometasone furoate (MF) is a topical corticosteroid used to reduce allergic and inflammation symptoms. In this study, MF was incorporated into the hydrophobic cavities of γ-cyclodextrin metal-organic frameworks (CD-MOFs) to prepare
Jie Li +8 more
doaj +2 more sources