Drug delivery in overcoming the blood-brain barrier: role of nasal mucosal grafting [PDF]
, 2017 The blood–brain barrier (BBB) plays a fundamental role in protecting and maintaining the homeostasis of the brain. For this reason, drug delivery to the brain is much more difficult than that to other compartments of the body. In order to bypass or cross
Carafa, Maria +5 more
core +1 more source
Successful Treatment of a Neonate with Idiopathic Persistent Pulmonary Hypertension with Inhaled Nitric Oxide via Nasal Cannula without Mechanical Ventilation. [PDF]
, 2012 We report a case study of a term neonate presenting with oxygen desaturation without respiratory distress or acidosis, despite receiving 100% oxygen through a nasal cannula.
Lakshminrusimha, Satyan +2 more
core +2 more sources
Inhaled Insulin: Intrapulmonary or Intranasal? [PDF]
, 2012 Initial attempts delivered the insulin hormone intramuscularly, intravenously, and eventually subcutaneously. Other routes of administration of the drug were explored.
Danish Ahmed +3 more
core +2 more sources
Safety and biodistribution of exosomes derived from human induced pluripotent stem cells
Frontiers in Bioengineering and Biotechnology, 2022 As a new cell-free therapy, exosomes have provided new ideas for the treatment of various diseases. Human induced pluripotent stem cells (hiPSCs) cannot be used in clinical trials because of tumorigenicity, but the exosomes derived from hiPSCs may ...
Zhewei Gu +11 more
doaj +1 more source
Improved Efficiency of Pomegranate Seed Oil Administrated Nasally
Pharmaceutics, 2022 Pomegranate seed oil (PSO) is currently administrated orally as a food supplement for improving memory. However, the efficiency of the oral dosage forms for such purposes is low, mainly due to the blood brain barrier impeding a good delivery to brain. In this work, we designed and characterized a PSO phospholipid oily gel for nasal administration.
Hiba Natsheh, Elka Touitou
openaire +3 more sources
Induction of chronic migraine phenotypes in a rat model after environmental irritant exposure [PDF]
, 2017 Air pollution is linked to increased emergency department visits for headache and migraine patients frequently cite chemicals or odors as headache triggers, but the association between air pollutants and headache is not well understood.
Hurley, Joyce Harts +4 more
core +1 more source
A new subunit vaccine based on nucleoprotein nanoparticles confers partial clinical and virological protection in calves against bovine respiratory syncytial virus [PDF]
, 2010 Human and bovine respiratory syncytial viruses (HRSV and BRSV) are two closely related, worldwide prevalent viruses that are the leading cause of severe airway disease in children and calves, respectively.
Bernadet, Philippe +14 more
core +2 more sources
ADMET and DMPKBackground and Purpose: Aiming to achieve light sedation via intranasal administration, this study showed that propofol (PPF) did not permeate across the rabbit nasal mucosa ex vivo from its marketed emulsion for injection.
Michele Domenico Spampinato +7 more
doaj +1 more source
Protective Effect of Insulin in Mouse Nasal Mucus Against Olfactory Epithelium Injury
Frontiers in Neural Circuits, 2021 Insulin is present in nasal mucus and plays an important role in the survival and activity of individual olfactory sensory neurons (OSNs) via insulin receptor-mediated signaling.
Shu Kikuta +2 more
doaj +1 more source
Pharmaceutics, 2021 We have recently reported Catalytides (Catalytic peptides) JAL-TA9 (YKGSGFRMI) and ANA-TA9 (SKGQAYRMI), which are the first Catalytides found to cleave Aβ42. Although the Catalytides must be delivered to the brain parenchyma to treat Alzheimer’s disease,
Yusuke Hatakawa +6 more
doaj +1 more source