Results 41 to 50 of about 262,065 (292)

The nasal delivery of nanoencapsulated statins – An approach for brain delivery [PDF]

, 2016
© 2016 Clementino et al. Purpose: Along with their cholesterol-lowering effect, statins have shown a wide range of pleiotropic effects potentially beneficial to neurodegenerative diseases.
Barboza, T, Batger, M, Cantù, L, Clementino, A, Del Favero, E, Garrastazu, G, Gutfilen, B, Pozzoli, M, Rondelli, V, Sonvico, F, Souza, SAL, Sukkar, MB   +11 more
core   +2 more sources

Research progress in brain-targeted nasal drug delivery

Frontiers in Aging Neuroscience
The unique anatomical and physiological connections between the nasal cavity and brain provide a pathway for bypassing the blood–brain barrier to allow for direct brain-targeted drug delivery through nasal administration.
Qingqing Huang, Qingqing Huang, Xin Chen, Sixun Yu, Gu Gong, Haifeng Shu, Haifeng Shu   +6 more
doaj   +1 more source

Recent Advances in Nose-to-Brain Gene Delivery for Central Nervous System Disorders

Pharmaceutics
The nasal route represents a promising non-invasive technique for the direct delivery of nucleic acids to the central nervous system (CNS) disorders, effectively bypassing the blood–brain barrier.
Flávia Nathiely Silveira Fachel, Angélica Salatino-Oliveira, Willian da Silva Carniel, Rafaela Zimmermann, Ursula Matte, Helder Ferreira Teixeira, Guilherme Baldo, Roselena Silvestri Schuh   +7 more
doaj   +1 more source

Frovatriptan succinate intranasal delivery for brain targeting – in vivo study.‎

The Iraqi Journal of Veterinary Medicine, 2023
Muco-adhesive gel formulations are advantageous in extending the stay at the nasal ‎absorption place, promoting drug absorption. Frovatriptan succinate (FVT) exhibits a 35% ‎oral bioavailability and undergoes hepatic metabolism, making it a viable ...
Mohammed layth hamzah, Hanan Jalal Kassab   +1 more
doaj   +1 more source

Administration of nasal medications to infants and young children – thematic analysis of parents’ experiences in online forum discussions and blogs [PDF]

, 2015
Background: Allergic rhinitis is an increasing problem among children in developed countries. A 12-year birth cohort study from 2001 to 2012 on Isle of Wight showed that current-rhinitis and lifetime-rhinitis prevalence increased by 5.5% (22.6-vs-28.1,
Bulbul, Alpaslan, Jones, Christina, Mukhopadhyay, Somnath, Smith, Helen   +3 more
core  

Antimicrobial use Guidelines for Treatment of Respiratory Tract Disease in Dogs and Cats: Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases [PDF]

, 2017
Respiratory tract disease can be associated with primary or secondary bacterial infections in dogs and cats and is a common reason for use and potential misuse, improper use, and overuse of antimicrobials.
Allen, Angus, Bannasch, Barrs, Beatty, Bennett, Berryessa, Bexfield, Binns, Bongrand, Boothe, Bradley, Burns, Chalker, Chalker, Chan, Chandler, Confalonieri, Danish Small Animal Veterinary Association (SvHKS), Dear, Demetriou, Demko, Dossin, Drawz, Egberink, Ellis, Erles, German, Guardabassi, Hartmann, Helps, Henderson, Hollis, Hunter, Jameson, Johnson, Johnson, Johnson, Johnson, Johnson, Keil, Kogan, Kompare, Lee, Lees, Levy, Lionel, Litster, MacPhail, Maggs, Martino, McInnis, McKiernan, Meijvis, Melendez, Meyers, Mochizuki, Morley, Mulholland, Murphy, Owen, Papich, Parnham, Peeters, Pesavento, Priestnall, Priestnall, Proulx, Pui-Ying, Quimby, Quimby, Radhakrishnan, Renshaw, Rheinwald, Rheinwald, Rooney, Rozanski, Ruch-Galle, Ruch-Gallie, Ruch-Gallie, Schulz, Schwarz, Sparkes, Speakman, Speakman, Spindel, Stillion, Sturgess, Sykes, Tart, Trow, Tynan, Vanderkooi, Veir, Velineni, Viitanen, Waddell, Walker, Welsh, Westfall, Wong, Zhu   +101 more
core   +4 more sources

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

Intranasal preoperative sedation with sufentanil in children

Медицина неотложных состояний
Background. Preoperative anxiety in children is a significant issue that negatively affects both their psycho-emotional state and surgical outcomes. Children aged 3–8 years often experience fear of separation from parents, of medical procedures, and drug
В.І. Коломаченко, І.Ю. Одинець, О.Є. Гавриков, В.І. Купін   +3 more
doaj   +1 more source

Implications of nasal delivery of bromelain on its pharmacokinetics, tissue distribution and pharmacodynamic profile-A preclinical study.

PLoS ONE, 2022
Asthma is a polygenic chronic inflammatory respiratory disease devastating the quality of life and state economies. Therefore, utilization of natural products as a therapeutic approach has attained wider consideration for development of novel drugs for ...
Manu Sharma, Namita Gupta, Easha Pandey
doaj   +1 more source

Use of balloon catheter dilation and steroid-eluting stent in light and severe rhinosinusitis of frontal sinus: a multicenter retrospective randomized study [PDF]

, 2018
OBJECTIVE: Frontal sinus surgery has an increased rate of re-stenosis, if compared to other sinuses, that mainly depends on recurrent inflammation and abnormal scarring at the frontal recess; its reduction represents one of the keys of therapeutic ...
Azimonti, Dario, CAVALIERE, CARLO, DE VINCENTIIS, Marco, Dragonetti, Alberto, Franzetti, Andrea, MINNI, Antonio, RALLI, MASSIMO, ROSATI, DAVIDE, SCIUTO, Antonino   +8 more
core   +1 more source