Results 21 to 30 of about 60,978 (331)

Using nasal sprays to prevent respiratory tract infections: a qualitative study of online consumer reviews and primary care patient interviews

BMJ Open, 2022
Objectives Nasal sprays could be a promising approach to preventing respiratory tract infections (RTIs). This study explored lay people’s perceptions and experiences of using nasal sprays to prevent RTIs to identify barriers and facilitators to their ...
Paul Little, Katherine Bradbury, Lucy Yardley, Adam W A Geraghty, Ben Ainsworth, Kate Greenwell, Deb Smith, Laura Dennison, Sian Williamson, James Denison-Day, Fiona Mowbray, Samantha Richards-Hall   +11 more
doaj   +1 more source

Nasal Lipopolysaccharide Challenge and Cytokine Measurement Reflects Innate Mucosal Immune Responsiveness [PDF]

, 2015
BackgroundPractical methods of monitoring innate immune mucosal responsiveness are lacking. Lipopolysaccharide (LPS) is a component of the cell wall of Gram negative bacteria and a potent activator of Toll-like receptor (TLR)-4.
Dhariwal, J, Francombe, G, Gilbert, J, Hansel, TT, Jones, RE, Kitson, J, Kon, OM, Murdoch, R, Nicholson, G, Openshaw, PJ, Tan, AJ, Tunstall, T, Walton, RP   +12 more
core   +7 more sources

Nasal Drug Delivery Systems: An Overview [PDF]

, 2015
Since ancient times, drugs have been administered via the nasal route for therapeutic and recreational purposes. The interest in, and importance, of the systemic effects of drugs administered through the nasal route, have expanded over recent decades ...
Conway, Barbara R., Ghori, Muhammad U., Mahdi, Mohammed H., Smith, Alan M.   +3 more
core   +1 more source

Spray characteristics from nasal spray atomization

Journal of Aerosol Science, 2022
In addition to topical delivery, nasal sprays offer an alternative drug administration route to the systemic circulation, therefore avoiding the need for painful, invasive delivery techniques. Studies on the efficacy of nasal drug delivery to date have been conflicting despite its potential. In particular computational studies, e.g. Computational Fluid
James Van Strien, Phred Petersen, Petros Lappas, Leslie Yeo, Amgad Rezk, Sara Vahaji, Kiao Inthavong   +6 more
openaire   +2 more sources

Corticosteroids for the common cold [PDF]

, 2015
BACKGROUND: The common cold is a frequent illness, which, although benign and self limiting, results in many consultations to primary care and considerable loss of school or work days. Current symptomatic treatments have limited benefit.
Del Mar, Chris B., Glasziou, Paul P., Hayward, Gail, Heneghan, Carl J., Perera, Rafael, Thompson, Matthew J.   +5 more
core   +1 more source

Nasal immune gene expression in response to azelastine and fluticasone propionate combination or monotherapy

Immunity, Inflammation and Disease, 2022
Background The combination of the antihistamine azelastine (AZE) with the corticosteroid fluticasone propionate (FP) in a single spray, has been reported to be significantly more effective at reducing allergic rhinitis (AR) symptoms than treatment with ...
Annabelle M. Watts, Nicholas P. West, Peter K. Smith, Ping Zhang, Allan W. Cripps, Amanda J. Cox   +5 more
doaj   +1 more source

A multicenter, open-label, long-term safety and tolerability study of DFN-02, an intranasal spray of sumatriptan 10 mg plus permeation enhancer DDM, for the acute treatment of episodic migraine. [PDF]

, 2017
BackgroundDFN-02 is a novel intranasal spray formulation composed of sumatriptan 10 mg and a permeation-enhancing excipient comprised of 0.2% 1-O-n-Dodecyl-β-D-Maltopyranoside (DDM).
Allenby, Kent, Brand-Schieber, Elimor, Cady, Roger K, Munjal, Sagar, Rapoport, Alan M, Spierings, Egilius LH   +5 more
core   +1 more source

Development of a physiologically relevant dripping analytical method using simulated nasal mucus for nasal spray formulation analysis

Journal of Pharmaceutical Analysis, 2016
Current methods for nasal spray formulations have been elementary evaluating the dripping characteristics of a formulation and have not assessed the behavior of the nasal formulation in the presence of varying types of mucus depending on the indication ...
Tina Masiuk, Parul Kadakia, Zhenyu Wang
doaj   +1 more source

Consistent safety and tolerability of Valtoco® (diazepam nasal spray) in relationship to usage frequency in patients with seizure clusters: Interim results from a phase 3, long‐term, open‐label, repeat‐dose safety study

Epilepsia Open, 2021
Objective Need for rescue therapy differs among patients with seizure clusters. Diazepam nasal spray is approved to treat seizure clusters in patients with epilepsy ≥6 years of age.
Ian Miller, James W. Wheless, Robert E. Hogan, Dennis Dlugos, Victor Biton, Gregory D. Cascino, Michael R. Sperling, Kore Liow, Blanca Vazquez, Eric B. Segal, Daniel Tarquinio, Weldon Mauney, Jay Desai, Adrian L. Rabinowicz, Enrique Carrazana, The DIAZ.001.05 Study Group   +15 more
doaj   +1 more source

Nasal Septal Perforation Due to Desmopressin Nasal Spray Use

Ear, Nose & Throat Journal, 2023
Perforations of the nasal septum have many etiologies and occasionally result from intranasal medicated spray use. This case report describes a perforation related to the use of desmopressin nasal spray, which has not been previously reported in the ...
Daniela A. Brake MD, Grant S. Hamilton MD, Stephen F. Bansberg MD   +2 more
doaj   +1 more source