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Drugs, 2008
Ciclesonide nasal spray delivers the corticosteroid ciclesonide as a hypotonic spray via a metered-dose manual pump. Systemic exposure to ciclesonide and its active metabolite desisobutyryl-ciclesonide is low after intranasal administration. High protein binding (approximately 99%) and rapid first-pass clearance further reduce systemic exposure to the ...
Sohita, Dhillon, Antona J, Wagstaff
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Ciclesonide nasal spray delivers the corticosteroid ciclesonide as a hypotonic spray via a metered-dose manual pump. Systemic exposure to ciclesonide and its active metabolite desisobutyryl-ciclesonide is low after intranasal administration. High protein binding (approximately 99%) and rapid first-pass clearance further reduce systemic exposure to the ...
Sohita, Dhillon, Antona J, Wagstaff
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Mometasone furoate nasal spray for nasal polyposis
Expert Review of Respiratory Medicine, 2007Nasal polyposis occurs in 2-4% of the general population and is associated with significant socioeconomic costs due to severe nasal/airway symptoms that impair quality of life. Nasal corticosteroids are the first-line therapy for nasal polyposis. Mometasone furoate nasal spray is effective in relieving nasal symptoms, including nasal congestion and ...
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Progesterone administration by nasal spray
Fertility and Sterility, 1991The bioavailability and the clinical usefulness of the P administered by nasal spray were investigated. Ten healthy menopausal women received an IN spray administration (4 doses of an oleic P solution 20 mg/mL, corresponding to nearly 11.2 mg of P) and the circulating P levels were calculated.
CICINELLI, Ettore +5 more
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Archives of Otolaryngology - Head and Neck Surgery, 1971
A jet spray instrument (Syrijet) has been used in nasal septal surgery and rhinoplastic surgery. The function of the instrument is to allow the most minimal discomfort when injecting, by needle, local anesthetics. This technique eliminates the need for routine packing of the nasal mucosa with cotton pledgets soaked with topical solutions of tetracaine (
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A jet spray instrument (Syrijet) has been used in nasal septal surgery and rhinoplastic surgery. The function of the instrument is to allow the most minimal discomfort when injecting, by needle, local anesthetics. This technique eliminates the need for routine packing of the nasal mucosa with cotton pledgets soaked with topical solutions of tetracaine (
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Nuclear Medicine Communications, 1984
SummaryThe sites of deposition and the rates of clearance of a radiolabelled nasal spray solution have been monitored using gamma scintigraphy. In patients with nasal polyposis the rates of clearance were much slower than in normal subjects and in general were not improved following polypectomy ...
STEPHEN W. LEE +3 more
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SummaryThe sites of deposition and the rates of clearance of a radiolabelled nasal spray solution have been monitored using gamma scintigraphy. In patients with nasal polyposis the rates of clearance were much slower than in normal subjects and in general were not improved following polypectomy ...
STEPHEN W. LEE +3 more
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World Journal of Biology Pharmacy and Health Sciences
A nasal spray is a liquid medication delivered into the nasal cavity through a spray device for local or systemic therapeutic effects. It is a non-invasive drug delivery system that offers several advantages, including ease of administration, rapid onset of action, avoidance of first-pass metabolism, and improved patient compliance.
Sarve, Shreya Ravindra +3 more
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A nasal spray is a liquid medication delivered into the nasal cavity through a spray device for local or systemic therapeutic effects. It is a non-invasive drug delivery system that offers several advantages, including ease of administration, rapid onset of action, avoidance of first-pass metabolism, and improved patient compliance.
Sarve, Shreya Ravindra +3 more
openaire +1 more source