Results 51 to 60 of about 11,359 (301)
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Scientific Reports, 2021 The implementation of radiomics in radiology is gaining interest due to its wide range of applications. To develop a radiomics-based model for classifying the etiology of liver cirrhosis using gadoxetic acid-enhanced MRI, 248 patients with a known ...
Aboelyazid Elkilany +6 more
doaj +1 more source
Advanced Science, EarlyView.This study reveals that dietary stachyose enriches Butyricimonas virosa, effectively attenuating metabolic dysfunction‐associated steatotic liver disease (MASLD). Mechanistically, B. virosa enhances gut thiamine monophosphate synthesis, which elevates hepatic thiamine pyrophosphate levels.
Ningning He +17 more
wiley +1 more source
Does Neuroticism Disrupt the Psychological Benefits of Nostalgia? A Meta‐analytic Test
European Journal of Personality, EarlyView., 2020 Abstract Nostalgia, a sentimental longing or wistful affection for the past, confers self‐oriented, existential, and social benefits. We examined whether nostalgic engagement is less beneficial for individuals who are high in neuroticism (i.e. emotionally unstable and prone to negative affect).
Julius Frankenbach +4 more
wiley +1 more source
Photoacoustic Microscopy for Multiscale Biological System Visualization and Clinical Translation
Advanced Science, EarlyView.Photoacoustic microscopy (PAM) is a powerful biomedical imaging tool renowned for its non‐invasiveness and high resolution. This review synthesizes recent technological advances and highlights their broad applications from cellular and organ‐level to whole‐animal imaging.
Tingting Wang +3 more
wiley +1 more source
A Statistical Mechanics Model to Decode Tissue Crosstalk During Graft Formation
Advanced Science, EarlyView.We introduce a statistical mechanics framework to decode the genomic crosstalk governing plant grafting. By integrating evolutionary game theory with transcriptomics, we reconstruct idopNetworks (informative, dynamic, omnidirectional, and personalized networks) that map scion–rootstock interactions.
Ang Dong +4 more
wiley +1 more source
Advanced Intelligent Systems, EarlyView.This study introduces a framework that combines graph neural networks with causal inference to forecast recurrence and uncover the clinical and pathological factors driving it. It further provides interpretability, validates risk factors via counterfactual and interventional analyses, and offers evidence‐based insights for treatment planning ...
Jubair Ahmed +3 more
wiley +1 more source
Biomedicines(1) Background: Nonalcoholic Steatohepatitis/Nonalcoholic Fatty Liver Disease (NASH/NAFLD) is the most recurrent chronic liver disease. NASH could present with a cholestatic (C) or hepatic (H) pattern of damage.
Daniela Cabibi +8 more
doaj +1 more source
Human‐Machine Mutual Trust Based Shared Control Framework for Intelligent Vehicles
Advanced Intelligent Systems, EarlyView.This work introduces a bidirectional‐trust‐driven shared control framework for human‐machine co‐driving. The method models human‐to‐machine trust from intention discrepancies and Bayesian skill assessment, and machine‐to‐human trust from integrated ability evaluation.
Zhishuai Yin +4 more
wiley +1 more source
Complexity, 2021 Specific to the NCSs where sensor signals can be processed centrally, a collaborative design scheme of dynamic game scheduling and advanced control theory was proposed in the present study.
Weixuan Wang +6 more
doaj +1 more source