Results 101 to 110 of about 61,475 (266)

Arrhythmias associated with immune checkpoint inhibitor therapy—A clinical perspective

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but are associated with a growing spectrum of cardiovascular immune‐related adverse events. Among these, arrhythmias represent a rare yet potentially life‐threatening complication. ICI‐induced arrhythmias encompass a wide clinical spectrum, including atrial arrhythmias, conduction ...
Dong Wang, Melanie Ricke‐Hoch, David Duncker, Johann Bauersachs, Dominik Berliner   +4 more
wiley   +1 more source

circMAN1A2 as an Isoform‐Resolved Circular RNA Hub in Cancer

Cancer Science, EarlyView.
circMAN1A2 as an isoform‐resolved circular RNA hub in cancer. circMAN1A2 is generated by back‐splicing of MAN1A2 pre‐mRNA, with alternative circularization producing multiple isoforms, including the predominant circMAN1A2(2–5). Its mechanistic interfaces include miRNA‐associated regulation, RBP binding/proteostasis control, BSJ‐mediated RNA–RNA pairing,
Hanyu Shang, Hui Wang, Yonghang Xu, Lingyun Geng, Yanqing Wang   +4 more
wiley   +1 more source

Repression of ROBO1 Enhances Cisplatin Sensitivity in Hypermethylated Subtype of HPV‐Positive Head and Neck Carcinoma

Cancer Science, EarlyView.
DNA hypermethylation causally correlates with better treatment response of HPV(+) HNSCC, and its chemosensitivity might be enhanced by silencing of methylation target genes. Silencing of ROBO1 enhances, and its overexpression reduces, CDDP chemosensitivity, and epigenetic or ROBO1‐targeted interventions may improve therapeutic outcomes in resistant HPV(
Kenta Saeda, Takuya Nakagawa, Atsushi Okabe, Kazuko Kita, Tomoya Kurokawa, Masaki Fukuyo, Hiroki Ueda, Motoaki Seki, Bahityar Rahmutulla, Syuji Yonekura, Toyoyuki Hanazawa, Atsushi Kaneda   +11 more
wiley   +1 more source

Final survival analysis of induction chemotherapy with lobaplatin and fluorouracil versus cisplatin and fluorouracil followed by concurrent chemoradiotherapy in nasopharyngeal carcinoma: a multicenter, randomized, phase 3 trial

Nature Communications
In nasopharyngeal carcinoma, cisplatin is known to be associated with poor treatment compliance and notable side effects. More effective and safer platinum drugs are needed for the treatment of patients with nasopharyngeal carcinoma.
Xun Cao, Jia-Yu Zhou, Hao-Yang Huang, Ling Guo, Ying-Ying Huang, Wen-Ze Qiu, Zhuo-Chen Lin, Ka-Jia Cao, Hao-Yuan Mo, Xian-Ming Li, Zi-Huang Li, Fei Han, Yu-Xiang He, Yu-Meng Liu, Yong-Rui Bai, Shao-Xiong Wu, Liang-Ru Ke, Xi Chen, Chi-Xiong Liang, Zhuo-Ying Luo, Yue Xia, Ying Deng, Jing-Jing Miao, Wei-Xiong Xia, Hu Liang, Chong Zhao, Yan-Qun Xiang, Xiang Guo, Xing Lv   +28 more
doaj   +1 more source

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, EarlyView.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Prevalence of mental disorders and their associations with age at diagnosis and time since diagnosis of nasopharyngeal cancer

Frontiers in Public Health
BackgroundDespite advancements in cancer treatment, understanding the long-term mental health implications for nasopharyngeal carcinoma (NPC) survivors remains an underexplored area. This study aims to examine the prevalence of mental disorders and their
Wen-Xuan Wang, Wen-Xuan Wang, Yi-Shan Wu, Yi-Shan Wu, Li-Ping Qi, Li-Ping Qi, Anise M. S. Wu, Anise M. S. Wu, Ying-Ying Zhu, Wei-Jie Gong, Shan-Shan Guo, Shan-Shan Guo, Yi-Jun Hua, Yi-Jun Hua, Dong-Hua Luo, Dong-Hua Luo, Qiu-Yan Chen, Qiu-Yan Chen, Yan-Qun Xiang, Yan-Qun Xiang, Jin-Xin Zhang, Hai-Qiang Mai, Hai-Qiang Mai, Ji-Bin Li, Ji-Bin Li   +24 more
doaj   +1 more source

Epstein‐Barr virus as a driver of lupus: Rethinking triggers in autoimmunity

Rheumatology &Autoimmunity, EarlyView.
Jiekai Tan, Fanlei Hu, Chuanhui Xu
wiley   +1 more source

S1 guideline sweat gland carcinoma

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary The current classification of sweat gland carcinomas is based on histomorphological characteristics and distinguishes between more than 20 entities. Most patients are older, but some subtypes also affect middle‐aged and younger patients. The majority of tumors arise de novo. Sweat gland carcinomas have nonspecific clinical features.
Mirjana Ziemer, Michael Erdmann, Abbas Agaimy, Jürgen C. Becker, Almut Böer‐Auer, Doris Helbig, Cornelia Erfurt‐Berge, Alexander Frisman, Conrad Hempel, Ulrike Leiter, Friedegund Meier, Thomas Mentzel, Lara Racz, Silke Redler, Stefan Schliep, Clemens Seidel, Alpaslan Tasdogan, Jochen Utikal, Carsten Weishaupt, Selma Ugurel   +19 more
wiley   +1 more source

Development and validation of a machine learning-based model for predicting radiation-induced hypothyroidism in nasopharyngeal carcinoma

Radiation Oncology
Background and purpose This study aims to develop a robust and user-friendly prediction model for radiation-induced hypothyroidism (RIHT) in nasopharyngeal carcinoma (NPC) patients. Materials and methods NPC patients treated with IMRT between Jan.
Fangyan Zhong, Wenchao Zhou, Xiying Gao, Dangchi Li, Jianming Zeng, Xiaopeng Xiong, Tianzhu Lu, Xiaochang Gong, Yun Xiao, Jingao Li   +9 more
doaj   +1 more source