Results 111 to 120 of about 73,649 (308)

BARF1 AS A NEW THERAPEUTIC TARGET FOR EBV-ASSOCIATED MALIGNANCIES.

, 2010
While Epstein-Barr virus-specific cytotoxic T lymphocytes (EBV-CTLs) have been used successfully for the prophylaxis and treatment of the highly immunogenic post-transplant lymphoproliferative disorders, the clinical experience for other EBV-associated ...
Martorelli, Debora
core  

Randomized Phase II Trial of Consolidation Pembrolizumab After Definitive Chemoradiotherapy in Locally Advanced Nasopharyngeal Carcinoma: KCSG HN19‐09, CONPELAN Study

Head &Neck, EarlyView.
ABSTRACT Background The benefit of consolidation programmed cell death protein 1 (PD‐1) blockade after chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma (NPC) remains unclear. Methods Patients with stages II–IVB NPC were randomized (2:1) to pembrolizumab 200 mg or placebo every 3 weeks for up to 17 cycles after chemoradiotherapy ...
Sang Hoon Chun, Seyoung Seo, Jang Ho Cho, Keon‐Uk Park, Sang‐Cheol Lee, Yong Won Choi, Tak Yun, Seong Hoon Shin, Sung‐Bae Kim, Seungeun Lee, Chang Ho Ahn, Bhumsuk Keam   +11 more
wiley   +1 more source

Discontinuation of immunotherapy and its effect on prognosis in recurrent or metastatic nasopharyngeal carcinoma patients: a retrospective analysis

Cancer Immunology, Immunotherapy
Purpose Immunotherapy has become the standard first-line treatment for recurrent or metastatic nasopharyngeal carcinoma (R/M NPC). This study aims to explore the impact of discontinuation of immunotherapy within 1 year on survival prognosis in patients ...
Yingpeng Peng, Xi Chu, Dasong Zha, Linghan Meng, Jijin Yao, Tianze Liu, Qiaodan Liu, Xiwei Xu, Siyang Wang, Mingyuan Chen, Rui You, Youping Liu   +11 more
doaj   +1 more source

Genetic and gene expression analysis of nasopharyngeal carcinoma (NPC) [PDF]

, 2010
We examined both the chromosomal copy number changes and differential RNA expression profiles in Nasopharyngeal carcinoma (NPC). Gene expression profiles identified a large number of differentially regulated genes involved in diverse functional processes,
Hu, Chunfang
core  

Upregulation of Id1 by Epstein-Barr Virus-encoded LMP1 confers resistance to TGFβ-mediated growth inhibition [PDF]

, 2010
Background Epstein-Barr virus (EBV)-encoded LMP1 protein is commonly expressed in nasopharyngeal carcinoma (NPC). LMP1 is a prime candidate for driving tumourigenesis given its ability to activate multiple signalling pathways and to alter the expression
Yanxing Yu, Lawrence S Young, Lo, KW, Dawson, Christopher W., Kwok W Lo, Lo, Angela, Angela KF Lo, Lo, Kwok W., Dawson, Christopher, Young, Lawrence, Yu, Yanxing, Lo, Angela K. F., Young, Lawrence S., Yu, Y, Christopher W Dawson   +14 more
core   +1 more source

The Role of Multicancer Early Detection Tests in Head and Neck Squamous Cell Carcinoma: A Case Series

Head &Neck, EarlyView.
ABSTRACT Background Head and neck squamous cell carcinoma (HNSCC) lacks an established screening program, and most cases are diagnosed at advanced stages. Multi‐cancer early detection (MCED) blood‐based assays represent a promising approach, yet real‐world clinical experience with MCED‐identified HNSCC remains limited.
Abhinav Talwar, Olivia Ben‐Levy, Nikhil Sriram, Sandeep Samant   +3 more
wiley   +1 more source

Test-retest reliability of a computer-assisted self-administered questionnaire on early life exposure in a nasopharyngeal carcinoma case-control study

Scientific Reports, 2018
We evaluated the reliability of early life nasopharyngeal carcinoma (NPC) aetiology factors in the questionnaire of an NPC case-control study in Hong Kong during 2014–2017.
Zhi-Ming Mai, Jia-Huang Lin, Shing-Chun Chiang, Roger Kai-Cheong Ngan, Dora Lai-Wan Kwong, Wai-Tong Ng, Alice Wan-Ying Ng, Kam-Tong Yuen, Kai-Ming Ip, Yap-Hang Chan, Anne Wing-Mui Lee, Sai-Yin Ho, Maria Li Lung, Tai-Hing Lam   +13 more
doaj   +1 more source

Recent advances in nasopharyngeal carcinoma (NPC) and EBV infection

, 2017
Undifferentiated nasopharyngeal carcinoma (NPC) is endemic among southern Chinese and is closely associated with Epstein-Barr virus (EBV) infection. The role of EBV in the pathogenesis of NPC remains enigmatic after long years of research.
Tsao, GSW
core  

The Addition of Concurrent Immune Checkpoint Inhibitors for Chemoradiotherapy With Consolidative Immune Checkpoint Inhibitors in Unresectable Cancers: A Systematic Review and Meta‐Analysis

International Journal of Cancer, EarlyView.
Currently, there are at least 30 ongoing clinical trials in the enrollment phase to evaluate adding concurrent ICIs to the PACIFIC regimen for a variety of solid tumors. Considering the lack of head‐to‐head comparative studies, this meta‐analysis aims to investigate the differences in efficacy between adding and not adding concurrent ICIs to CRT ...
Xu Tong, Zhenting Liu, Xiaoxiang Zhou, Nan Bi, Yibo Gao   +4 more
wiley   +1 more source

The 9th Edition of the UICC TNM Classification of Malignant Tumours: Updates and Rationale for Change

International Journal of Cancer, EarlyView.
ABSTRACT The standard for assessing and recording the extent of the tumour, a necessity for most malignancies, is the Tumour Node Metastases (TNM) classification. The Union for International Cancer Control (UICC) TNM committee has defined this since the early 1950s.
James D. Brierley, Liesbet J. Van Eycken, Meredith E. Giuliani, Brian A. Rous, Shao Hui Huang, Hisao Asamura, Mary K. Gospodarowicz, Anne W. Lee, Brian O'Sullivan   +8 more
wiley   +1 more source