Results 141 to 150 of about 1,451,429 (415)

Mutations in pathways depending on BRCA1 and BRCA2 may increase cancer risks from an environmental carcinogen [PDF]

, 2011
Recently, the President’s Cancer Panel [2008-2009] protested that preventive action is not taken when uncertainty exists about potential harm from a chemical, because the US regulatory approach demands that a hazard be incontrovertibly ...
Bernard Friedenson
core   +2 more sources

A randomized, double‐blind, placebo‐controlled trial of probiotics to reduce the severity of oral mucositis induced by chemoradiotherapy for patients with nasopharyngeal carcinoma

Cancer, 2018
The objective of this study was to evaluate the effect of a probiotic combination on the severity of oral mucositis (OM), which is a common, unpreventable complication induced by radiochemotherapy in patients with nasopharyngeal carcinoma who undergo ...
Chunling Jiang, Huan Wang, Chaofei Xia, Qing Dong, E. Chen, Yang Qiu, Yong Su, Honghui Xie, L. Zeng, Jie Kuang, Fan Ao, X. Gong, Jingao Li, Tingtao Chen   +13 more
semanticscholar   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Combination strategy exploration for prior treated recurrent or metastatic nasopharyngeal carcinoma in the era of immunotherapy

Scientific Reports
To assess the efficacy and safety of the combination of immune checkpoint inhibitors (ICIs) and target therapy (anti-angiogenesis or EGFR inhibitors) as a second-line or subsequent treatment for recurrent or metastatic nasopharyngeal carcinoma (R/M NPC),
Yaofei Jiang, Chun Chen, Guoying Liu, Ting Fang, Nian Lu, Weixin Bei, Shuhui Dong, Wangzhong Li, Weixiong Xia, Hu Liang, Yanqun Xiang   +10 more
doaj   +1 more source

Paclitaxel liposome, cisplatin and 5-fluorouracil-based induction chemotherapy followed by de-escalated intensity-modulated radiotherapy with concurrent cisplatin in stage IVA–IVB childhood nasopharyngeal carcinoma in endemic area: a phase II, single-arm trialResearch in context

The Lancet Regional Health. Western Pacific, 2023
Summary: Background: Previous studies demonstrated that induction chemotherapy (IC) followed by de-escalated chemoradiotherapy adapted to tumor response was effective in treating childhood nasopharyngeal carcinoma (NPC), but the toxicity profile of this
Dong-Hua Luo, Xiao-Yun Li, Shan-Shan Guo, Wan-Ping Guo, Li-Ting Liu, Hao-Yuan Mo, Ling Guo, Xiao-Fei Lv, Li-Zhi Liu, Ji-Bin Li, Qing Liu, Pan Wang, Xue-Song Sun, Sai-Lan Liu, Qiu-Yan Chen, Lin-Quan Tang, Hai-Qiang Mai   +16 more
doaj  

A study of the etiology of referred Otalgia [PDF]

, 2012
Introduction: Otalgia is one of the complaints which may occur at any age. The etiology of the pain may be in the ear, structures around the ear or other head and neck structures.
Behnampour, N., Taziki, M.H.
core   +1 more source

Nasopharyngeal carcinoma: A review of current updates

Experimental and Therapeutic Medicine, 2018
Nasopharyngeal carcinoma (NPC) is a rare malignancy worldwide, but it is endemic in a few areas including Southern China, Southeast Asia, North Africa and the Arctic. The underlying mechanisms behind this remarkable geographic distribution remain unclear.
Lei Wu, Churong Li, L. Pan
semanticscholar   +1 more source

Prospective Registry Trial of Adjuvant High‐Dose Rate Brachytherapy in Unirradiated Head and Neck Cancer: 20‐Year Data

Head &Neck, EarlyView.
ABSTRACT Background and Purpose Full‐dose postoperative external beam radiation therapy (EBRT)/chemoradiation is the standard of care in patients with resected, unirradiated head and neck cancer (HNC). This study aims to determine the long‐term results of adjuvant high‐dose rate (HDR) brachytherapy ± intermediate‐dose postoperative external beam ...
Alejandro García‐Consuegra, Marta Gimeno‐Morales, Mauricio Cambeiro, José María López‐Picazo, Juan Alcalde, Luis I Ramos, Luca Tagliaferri, José Luis Guinot, Francesco Bussu, Marta Moreno‐Jiménez, Rafael Martinez‐Monge   +10 more
wiley   +1 more source

DSU-net: Dense SegU-net for automatic head-and-neck tumor segmentation in MR images [PDF]

arXiv, 2020
Precise and accurate segmentation of the most common head-and-neck tumor, nasopharyngeal carcinoma (NPC), in MRI sheds light on treatment and regulatory decisions making. However, the large variations in the lesion size and shape of NPC, boundary ambiguity, as well as the limited available annotated samples conspire NPC segmentation in MRI towards a ...
arxiv  

PaperRobot: Incremental Draft Generation of Scientific Ideas

, 2019
We present a PaperRobot who performs as an automatic research assistant by (1) conducting deep understanding of a large collection of human-written papers in a target domain and constructing comprehensive background knowledge graphs (KGs); (2) creating ...
Bansal, Mohit, Huang, Lifu, Ji, Heng, Jiang, Zhiying, Knight, Kevin, Luan, Yi, Wang, Qingyun   +6 more
core   +1 more source