Results 141 to 150 of about 128,444 (337)

Case Report of Maxillary Alveolar Rhabdomyosarcoma Misdiagnosed as Periapical Lesion: Clinicopathological Alerts and Life‐Saving Lessons for Dentists

Australian Endodontic Journal, EarlyView.
ABSTRACT This report describes a rare case of alveolar rhabdomyosarcoma initially presenting with clinical features resembling an endodontic lesion. A 15‐year‐old male presented with progressive right maxillary swelling initially treated as a dental abscess.
Saliha Akçay Köprücü, Erdal Rahman Köprücü, Aysun Atasoy Sındıraç, Ümit Çobanoğlu   +3 more
wiley   +1 more source

Beneficence‐Based Obligations and Ethics Consultation in Assisted Dying

Bioethics, EarlyView.
ABSTRACT In ethical debates on assisted dying, the principle of respect for autonomy is usually invoked to justify respecting requests for assisted dying. However, there are not only autonomy‐based obligations, but also obligations arising from the principle of beneficence towards persons requesting assisted dying.
Georg Marckmann, Anna Hirsch
wiley   +1 more source

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

Overexpression of Transferrin Receptor in Esophageal Squamous Cell Cancer Suggests Poor Prognosis and Potential Therapy

Cancer Science, EarlyView.
This study aimed to evaluate transferrin receptor (TfR) expression in human esophageal squamous cell cancer (ESCC) specimens and investigate the correlation between TfR overexpression and clinicopathological characteristics. Furthermore, we explored the potential of targeting iron metabolism pathways as a novel therapeutic strategy for ESCC.
Naoki Ikenaga, Tsuyoshi Takahashi, Koji Tanaka, Satoshi Serada, Minoru Fujimoto, Kota Momose, Kotaro Yamashita, Tomoki Makino, Takuro Saito, Kazuyoshi Yamamoto, Yukinori Kurokawa, Kiyokazu Nakajima, Tomomi Fujii, Eiichi Morii, Tetsuji Naka, Hidetoshi Eguchi, Yuichiro Doki   +16 more
wiley   +1 more source

The Positive Feedback of lncRNA ANRIL/miRNA‐339‐5p/ZBTB7A Suppresses Metastasis of Nasopharyngeal Carcinoma Cells via SREBP1‐FASN

Cancer Science, EarlyView.
Disruptions in lipid metabolism can hasten disease progression and impose a heavier burden on patients with nasopharyngeal carcinoma (NPC). The ANRIL/miR‐339‐5p/ZBTB7A axis creates a positive feedback loop that suppresses the lipid pathway. Furthermore, the interventions targeting ANRIL‐shZBTB7A and SREBP inhibitors can effectively disrupt lipid ...
Fei Liu, Jiazhang Wei, Suosu Wei, Mingzheng Mo, Jiao Lan, Jingjin Weng, Ruiping Xiao, Cheng Su, Weiming Deng, Yujuan Huang, Bing Li, Min Li, Le Shi, Yuanjun Zhan, Yunhua Peng, Yongli Wang, Fengzhu Tang, Huadong Liu, Shenhong Qu, Jiangang Long   +19 more
wiley   +1 more source

The LGALS9/miR‐491‐5p Axis Regulates CD8+ T Cell Function and Inhibits the Progression of Gastric Cancer

Cancer Science, EarlyView.
In this study, we found that LGALS9 is highly expressed in gastric cancer and may affect the development of gastric cancer by participating in the infiltration of CD8+ T cells. Knockout of LGALS9 can reverse T cell function and relieve immunosuppression, and enhance the killing effect of T cells on gastric cancer cells.
Wanzhong Huang, Wei Zheng, Dagao Zhu, Zhi Sun, Wei Lu, Jun Tao, Chen Liu, Liangliang Li, Yingli Zhou, Honghong Fan, Hong Tao, Wenjuan Li   +11 more
wiley   +1 more source

Construction, expression, and characterization of rSEA-EGF and in vitro evaluation of its antitumor activity against nasopharyngeal cancer [PDF]

, 2018
He, Ying, Liu, Xueting, Tao, Ailin, Wang, Shan, Xie, Yang, Zeng, Liping, Zhang, Jianguo, Zhang, Junyan, Zhou, Zhongqiu, Zou, Zehong   +9 more
core   +2 more sources

A11 Peptide Enhances Radiosensitivity by Degrading EphA2 in Nasopharyngeal Carcinoma

Cancer Science, EarlyView.
In EphA2‐high‐expressing nasopharyngeal carcinoma cells, radiation triggers RSK‐dependent phosphorylation of EphA2 at Ser897, which in turn activates AKT and promote radioresistance. The A11 peptide breaks this signaling cascade by degrading EphA2 and blocking its S897 phosphorylation, thereby markedly enhancing radiosensitivity.
Ming Zhang, Zhi‐Qiang Xiao, Wei Huang, Shan‐Shan Lu, Hong Yi, Juan Feng   +5 more
wiley   +1 more source

The value of 18F-fluorodeoxyglucose-positron emission tomography/ computed tomography (18F- FDG PET/CT) in the staging and impact on the management of patients with nasopharyngeal carcinoma [PDF]

, 2017
This study sought to prospectively evaluate the influence of contrasted fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDGPET/CT) in the staging of and impact on the management plan for treatment in patients with ...
Abu Bakar, Saraiza, Ahmad Saad, Fathinul Fikri, Nordin, Abdul Jalil, Subha, Sethu Thakachy   +3 more
core  

Oral Health—Head and Neck Cancers: Addressing Confounding Through Negative Control and Quantitative Bias Analyses

Community Dentistry and Oral Epidemiology, EarlyView.
ABSTRACT Objectives While there are plausible biological explanations for the association between oral health and head and neck cancers (HNC), existing studies have yielded conflicting results. A key concern is that these associations are influenced by mediators, unmeasured risk factors, and biases. To address this, a negative control exposure was used
P. K. Elango, B. Nicolau, N. Farsi, A. V. Grant, M. C. Rousseau, S. Madathil   +5 more
wiley   +1 more source