Results 201 to 210 of about 61,475 (266)

Epithelial YPEL3 Modulates CD8+ T‐Cell Infiltration and Tumor Progression Through CREB1–CXCL16 Signaling in HNSCC

open access: yesCancer Science, Volume 117, Issue 8, Page 2132-2151, August 2026.
YPEL3 functions as a tumor suppressor in HNSCC by inhibiting tumor progression and promoting apoptosis. Mechanistically, it enhances epithelial–immune crosstalk through the CREB1‐mediated CXCL16–CXCR6 axis, facilitating CD8+ T‐cell infiltration and highlighting its potential as a prognostic biomarker and immunotherapy target.
Yalun Li   +7 more
wiley   +1 more source

Translating Asian‐Dominant Pivotal Evidence Into EU Marketing Authorization: An EMA Regulatory Document Analysis, 2021–2025

open access: yesClinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT An increasing number of novel molecular entities and biosimilars reach the European Medicines Agency (EMA) supported by pivotal evidence derived predominantly from Asian patient populations. This creates regulatory challenges that the existing ICH E5 framework was not originally designed to address.
Prerona Boruah, Alex Zwiers
wiley   +1 more source

Validity of the Translated Turkish Version of the Tool for Nutrition Risk Screening for Paediatric Cancer

open access: yesInternational Journal of Nursing Practice, Volume 32, Issue 4, August 2026.
ABSTRACT Background Malnutrition in paediatric cancer patients increases adverse clinical outcomes; however, methods for assessing malnutrition risk remain unclear. This study aimed to assess the validity of the Nutrition Risk Screening for Pediatric Cancer (NRS‐PC).
Buket Meral   +2 more
wiley   +1 more source

The Prognostic Significance of Tertiary Lymphoid Structures in Head and Neck Cancers: A Systematic Review and Meta‐Analysis

open access: yesJournal of Oral Pathology &Medicine, Volume 55, Issue 7, Page 774-783, August 2026.
ABSTRACT Background Head and neck squamous cell carcinoma (HNSCC), particularly oral squamous cell carcinoma (OSCC), is associated with poor survival despite therapeutic advances. Tertiary lymphoid structures (TLSs) are emerging components of the tumor microenvironment, but their prognostic significance in HNSCC remains unclear.
Everton Freitas de Morais   +4 more
wiley   +1 more source

Computed tomographic features of presumed normal palatine tonsils in 140 dogs

open access: yesJournal of Small Animal Practice, Volume 67, Issue 8, Page 739-748, August 2026.
Objectives The purpose of this retrospective study was to describe the CT features of presumed normal canine palatine tonsils. Materials and Methods Pre‐ and post‐contrast head CT studies of 140 dogs without tonsillar disease were included. Subjective evaluation of palatine tonsils included contrast enhancement pattern, differentiation from surrounding
N. Leong, R. Drees, H. Dirrig
wiley   +1 more source

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