ABSTRACT Introduction The past two decades have seen a paradigm shift in the surgical treatment of sinonasal malignancies, moving from traditional open approaches to minimally invasive endoscopic techniques. Technological advancements have enabled the use of the endoscopic endonasal transcribriform approach (EETA) for tumors involving the anterior ...
Michel Khalaf+11 more
wiley +1 more source
The relationship between cathepsins and nasopharyngeal carcinoma: a Mendelian randomization analysis. [PDF]
Hu J, Lin K, Jiang M, Qiao G.
europepmc +1 more source
Malignancies Presenting With ANCA Positivity: Two Case Reports and Diagnostic Considerations
ABSTRACT Background ANCA‐associated vasculitides (AAV) are small‐vessel inflammatory disorders characterized by the presence of anti‐neutrophil cytoplasmic antibodies (ANCA), including those against proteinase 3 (PR3) and myeloperoxidase (MPO).
Min Zhao, Yue Lu, Ling Li
wiley +1 more source
Clinical outcomes and prognostic factors of stereotactic body radiation therapy in metastatic nasopharyngeal carcinoma. [PDF]
Zhu Y, Xue F.
europepmc +1 more source
ABSTRACT Background Head and neck cancers (HNCs) are the 6th most common cancer diagnosis and mortality worldwide, with a case fatality rate of 51% per annum. In Tanzania, HNC incidence and mortality rates are 4% per annum, with a case fatality rate of 69% per annum.
Marco R. Magwizi+8 more
wiley +1 more source
Targeting the FOXA1/BMI1 axis to overcome chemoresistance and suppress tumor progression in nasopharyngeal carcinoma. [PDF]
Qin Y+6 more
europepmc +1 more source
PI3K/AKT/mTOR Axis in Cancer: From Pathogenesis to Treatment
The PI3K/AKT/mTOR signaling axis is crucial in cancer progression, regulating cell growth, survival, and metabolism. Often hyperactivated through mutations or loss of tumor suppressors such as PTEN, this pathway promotes cancer cell proliferation and survival by inhibiting apoptosis and activating mTOR, which drives protein synthesis and suppresses ...
Mingyang Jiang+10 more
wiley +1 more source
Dermatomyositis as the First Manifestation of Nasopharyngeal Carcinoma-A Rare Case Report. [PDF]
Knežević B+2 more
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Applications of Artificial Intelligence in Biotech Drug Discovery and Product Development
Artificial intelligence is reshaping drug discovery by enhancing molecular design, target engagement, and therapeutic delivery with unprecedented precision and efficiency. This review summarizes recent advances in AI‐driven approaches across small molecule design, protein binder development, antibody engineering, and nanoparticle‐based delivery systems,
Yuan‐Tao Liu+14 more
wiley +1 more source
Premature termination of DNA Damage Repair by 3-Methyladenine potentiates cisplatin cytotoxicity in nasopharyngeal carcinoma cells. [PDF]
Zhou J, Liu S, Deng J, He L, Jiang B.
europepmc +1 more source