Results 331 to 340 of about 1,463,832 (396)

Safety and Oncologic Outcomes of Endoscopic Endonasal Transcribriform Approach for Locally Advanced Sinonasal Malignancies

open access: yesHead &Neck, Volume 47, Issue 8, Page 2348-2357, August 2025.
ABSTRACT Introduction The past two decades have seen a paradigm shift in the surgical treatment of sinonasal malignancies, moving from traditional open approaches to minimally invasive endoscopic techniques. Technological advancements have enabled the use of the endoscopic endonasal transcribriform approach (EETA) for tumors involving the anterior ...
Michel Khalaf   +11 more
wiley   +1 more source

Malignancies Presenting With ANCA Positivity: Two Case Reports and Diagnostic Considerations

open access: yesImmunity, Inflammation and Disease, Volume 13, Issue 8, August 2025.
ABSTRACT Background ANCA‐associated vasculitides (AAV) are small‐vessel inflammatory disorders characterized by the presence of anti‐neutrophil cytoplasmic antibodies (ANCA), including those against proteinase 3 (PR3) and myeloperoxidase (MPO).
Min Zhao, Yue Lu, Ling Li
wiley   +1 more source

Head and Neck Cancer: Trends and Geographical Distribution of Head and Neck Cancer at a Tertiary Hospital in Northern Tanzania

open access: yesLaryngoscope Investigative Otolaryngology, Volume 10, Issue 4, August 2025.
ABSTRACT Background Head and neck cancers (HNCs) are the 6th most common cancer diagnosis and mortality worldwide, with a case fatality rate of 51% per annum. In Tanzania, HNC incidence and mortality rates are 4% per annum, with a case fatality rate of 69% per annum.
Marco R. Magwizi   +8 more
wiley   +1 more source

PI3K/AKT/mTOR Axis in Cancer: From Pathogenesis to Treatment

open access: yesMedComm, Volume 6, Issue 8, August 2025.
The PI3K/AKT/mTOR signaling axis is crucial in cancer progression, regulating cell growth, survival, and metabolism. Often hyperactivated through mutations or loss of tumor suppressors such as PTEN, this pathway promotes cancer cell proliferation and survival by inhibiting apoptosis and activating mTOR, which drives protein synthesis and suppresses ...
Mingyang Jiang   +10 more
wiley   +1 more source

Applications of Artificial Intelligence in Biotech Drug Discovery and Product Development

open access: yesMedComm, Volume 6, Issue 8, August 2025.
Artificial intelligence is reshaping drug discovery by enhancing molecular design, target engagement, and therapeutic delivery with unprecedented precision and efficiency. This review summarizes recent advances in AI‐driven approaches across small molecule design, protein binder development, antibody engineering, and nanoparticle‐based delivery systems,
Yuan‐Tao Liu   +14 more
wiley   +1 more source

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