Results 71 to 80 of about 131,451 (349)

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

A Nanobody‐LNP Platform for Targeting and Relicensing Dendritic Cells for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
Plastin‐2 (PLS2) is identified as a dual‐function receptor on DCs that mediates both nanoparticle uptake and immunomodulation. A nanobody‐LNP platform is engineered to integrate antigen delivery with relicensing DCs. The therapeutic strategy elicits potent anti‐tumor T cell responses and leads to significant inhibition of established tumors in vivo ...
Shugang Qin, Zhiying Huang, Hai Huang, Yupei Zhang, Yuting Chen, Xi He, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Xiangrong Song   +9 more
wiley   +1 more source

Nasopharyngeal Myoepithelial Carcinoma Mimicking Nasopharyngeal Carcinoma

Journal of Cancer Research and Practice, 2015
AbstractMyoepithelial carcinoma (malignant myoepithelioma) (MC) is a rare tumor, defined as a malignant salivary neoplasm composed almost exclusively of tumor cells with myoepithelial differentiation. It can arise in unusual location sites, such as the nasopharynx, and may be difficult to approach.
Chieh-Sheng Lu, Yi-Jen Peng, Hung-Wen Kao, Hsin-Chien Chen, Ching-Liang Ho, Ping-Ying Chang   +5 more
openaire   +2 more sources

The mediating role of loneliness between psychological resilience and health-related quality of life among patients with nasopharyngeal carcinoma: a cross-sectional study using structural equation modeling

BMC Psychiatry
Background Cancer patients’ health-related quality of life (HRQoL) has always been a hot discussion spot. Loneliness and psychological resilience are considered to be significant psychosocial factors impacting the HRQoL of the cancer population. However,
Mengna Luo, Siting Lin, Zhenxiu Li, Liping Wu, Linmin Chen, Qiulan Yang, Yuying Fan   +6 more
doaj   +1 more source

Proposed prognostic subgroups and facilitated clinical decision-making for additional locoregional radiotherapy in de novo metastatic nasopharyngeal carcinoma: a retrospective study based on recursive partitioning analysis

Radiation Oncology, 2023
Background The high heterogeneity of de novo metastatic nasopharyngeal carcinoma (dmNPC) makes its prognosis and treatment challenging. We aimed to accurately stage dmNPC and assess the patterns of treatment strategies for different risk groups.
Yuyi Yao, Xuesong Sun, Huageng Huang, Zhao Wang, Xiaojie Fang, Meiting Chen, Zegeng Chen, Huawei Weng, Chengcheng Guo, Huangming Hong, He Huang, Tongyu Lin   +11 more
doaj   +1 more source

A study of the etiology of referred Otalgia [PDF]

, 2012
Introduction: Otalgia is one of the complaints which may occur at any age. The etiology of the pain may be in the ear, structures around the ear or other head and neck structures.
Behnampour, N., Taziki, M.H.
core   +1 more source

Adverse prognostic and predictive significance of low DNA-dependent protein kinase catalytic subunit (DNA-PKcs) expression in early-stage breast cancers [PDF]

, 2014
Background: DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a serine threonine kinase belonging to the PIKK family (phosphoinositide 3-kinase-like-family of protein kinase), is a critical component of the non-homologous end joining (NHEJ ...
AC Wolff, Andrew R. Green, Arvind Arora, B Salles, C Curtis, Christina Perry, Devika Agarwal, Emad Rakha, ET Shinohara, FM Hsu, Graham Ball, HS Lee, HS Lee, Ian O. Ellis, JA Neal, K Meek, K Soderlund Leifler, L Du, LA Loeb, LA Loeb, LM McShane, M Burg van der, Nicola Thompson, Paul Moseley, R Hill, R Sultana, S Medunjanin, SJ Collis, SL Shao, Srinivasan Madhusudan, Stephen Chan, SY Wang, Tarek Abdel-Fatah, TM Abdel-Fatah, TM Abdel-Fatah, TM Abdel-Fatah, U Moll, W Zhuang, X Kong, X Wang, XD Long, Z Hu   +41 more
core   +2 more sources

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Effect of Administration of Phaleria Macrocarpa on Liver Function of Nasopharyngeal Carcinoma Patients who Receive Cisplatin Chemotherapy [PDF]

, 2022
Adi Januar Akbar, Willy Yusmawan, Farokah Farokah, Nur Iman Nugroho   +3 more
openalex   +1 more source

Joint modeling of longitudinal health-related quality of life during concurrent chemoradiotherapy period and long-term survival among patients with advanced nasopharyngeal carcinoma

Radiation Oncology
Background To investigate the prognosis of longitudinal health-related quality of life (HRQOL) during concurrent chemoradiotherapy (CCRT) on survival outcomes in patients with advanced nasopharyngeal carcinoma (NPC).
Ji-Bin Li, Shan-Shan Guo, Ting Liu, Zhuo-Chen Lin, Wei-Jie Gong, Lin-Quan Tang, Ling Guo, Hao-Yuan Mo, Hai-Qiang Mai, Qiu-Yan Chen   +9 more
doaj   +1 more source