Results 51 to 60 of about 6,423 (263)

A Field Test of Major Value Frameworks in Chemotherapy of Nasopharyngeal Carcinoma—To Know, Then to Measure

Frontiers in Oncology, 2020
Background: The European Society for Medical Oncology (ESMO) and the American Society of Clinical Oncology (ASCO) have independently developed their own frameworks to assess the benefits of different cancer treatment options, which have significant ...
Yuan Zhang, Xu Liu, Ying-Qin Li, Ling-Long Tang, Lei Chen, Lei Chen, Jun Ma   +6 more
doaj   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Nasopharyngeal masses in adults—A retrospective analysis of 255 patients to evaluate symptoms, clinical findings, and histological results

World Journal of Otorhinolaryngology-Head and Neck Surgery
Background Nasopharyngeal tissue hyperplasia is generally associated with adenoids in childhood. In adults, nasopharyngeal masses are occasionally found, but data on symptoms, clinical findings, and histologic results are limited.
Melanie M. vonWitzleben, Adrian vonWitzleben, Thomas K. Hoffmann, Janina Hahn   +3 more
doaj   +1 more source

Juvenile nasopharyngeal angiofibroma

Journal of Indian Academy of Oral Medicine and Radiology, 2011
Juvenile nasopharyngeal angiofibroma (JNA) is a relatively uncommon neoplasm occurring almost exclusively in the nasopharynx of adolescent males) Occasional cases have extended to involve the oral cavity.′ JNA is a histologically benign yet locally ...
M Manjunath, T A Deepak, K C Mayank
doaj   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

NIPAL1 Drives a Metabolic‐Epigenetic Feedback Loop to Promote Lactate‐Mediated Immune Evasion in Esophageal Cancer

Advanced Science, EarlyView.
The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen, Xiao‐Dan Ma, Shui‐Dan Xu, Ao‐Tian Mo, Min‐Hua Deng, Jun‐Han Wu, Wei‐Tao Zhuang, Jin‐Ling Duan, Shu‐Huan Xie, Jin‐Long Lin, Peng Lin, Ji‐Ming Tang, Hai‐Yu Zhou, Xiao‐Song Ben, Gui‐Bin Qiao, Dan Xie   +15 more
wiley   +1 more source

Intensity modulated radiotherapy (IMRT) in the treatment of children and Adolescents - a single institution's experience and a review of the literature [PDF]

, 2009
Background While IMRT is widely used in treating complex oncological cases in adults, it is not commonly used in pediatric radiation oncology for a variety of reasons. This report evaluates our 9 year experience using stereotactic-guided, inverse planned
Florian Sterzing, Eva M Stoiber, Simeon Nill, Harald Bauer, Peter Huber, Jürgen Debus, Marc W Münter, Intensity Modulated Radiation Therapy Collaborative Working Group, A Eisbruch, C Nutting, A Pirzkall, W Zhen, MW Munter, D Schulz-Ertner, MW Munter, SL Wolden, G Studer, ML Cavey, M Guckenberger, L Veldeman, F Sterzing, A Boyer, TR Mackie, EJ Hall, EJ Hall, SF Kry, U Schneider, M Mazonakis, B Rhein, A Bhatnagar, JA Penagaricano, AC Paulino, BS Teh, JA Penagaricano, E Huang, N Jain, MJ Krasin, TM Schroeder, MW McDonald, AE Curtis, SE Combs, S Laskar, RB Kuppersmith, M Fuss, D Verellen, M Koshy, JS Welsh, EJ Hall, J Blatt, DG Gold, AC Paulino, HM Lin, LL Robison, GT Armstrong, F Nguyen, W Dorr, W Parker, A Rembielak   +57 more
core   +1 more source

Extra-nasopharyngeal Angiofibroma: A Rare Case Report

National Board of Examinations Journal of Medical Sciences
An extra-nasopharyngeal angiofibroma (ENA) is a rare, atypical tumour that arises from sites other than the sphenopalatine foramen. It has a very variable clinical presentation depending on the site of origin, can occur at any age, and does not have a ...
Aditya Shikar Bhattacharya, Kaushik Bhattacharya, Neela Bhattacharya   +2 more
doaj   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

PaperRobot: Incremental Draft Generation of Scientific Ideas

, 2019
We present a PaperRobot who performs as an automatic research assistant by (1) conducting deep understanding of a large collection of human-written papers in a target domain and constructing comprehensive background knowledge graphs (KGs); (2) creating ...
Bansal, Mohit, Huang, Lifu, Ji, Heng, Jiang, Zhiying, Knight, Kevin, Luan, Yi, Wang, Qingyun   +6 more
core   +1 more source