Results 111 to 120 of about 373,386 (221)
BZW1 Drives Immune Evasion in Lung Adenocarcinoma via Ferroptosis Suppression
Advanced Science, EarlyView.BZW1 attenuates ferroptosis by competitively binding NCOA4 and suppress ferrtinophagy‐mediated iron release. The depletion of BZW1 triggers lipid peroxidation through iron homeostasis. Extracellularly, BZW1 attenuates immunogenic cell death and reinvigorates cytotoxic T‐cell responses.
Linyao Zhao +9 more
wiley +1 more source
BackgroundAlthough it has been well-documented that obesity is associated with decreased risk of premenopausal breast cancer and increased risk of postmenopausal breast cancer, it is unclear whether these associations differ among breast cancer subtypes ...
core
2014 Cancer in Iowa Report, 2014 [PDF]
, 2014 Cancer is a reportable disease as stated in the Iowa Administrative Code. Cancer data are collected by the State Health Registry of Iowa, located at The University of Iowa in the College of Public Health’s Department of Epidemiology.
core
Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Advanced Science, EarlyView.Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
wiley +1 more source
Loss of the PTCH1 tumor suppressor defines a new subset of plexiform fibromyxoma. [PDF]
, 2019 BackgroundPlexiform fibromyxoma (PF) is a rare gastric tumor often confused with gastrointestinal stromal tumor. These so-called "benign" tumors often present with upper GI bleeding and gastric outlet obstruction.
Banerjee, Sudeep +9 more
core +1 more source
DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics
Advanced Science, EarlyView.This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei +12 more
wiley +1 more source
Advanced Science, EarlyView.This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy +16 more
wiley +1 more source
Clinical and Translational MedicinePatients with advanced gastric and colorectal cancers have limited treatment options. Since mesothelin is highly expressed in these tumour types, we evaluated the therapeutic benefits of anti‐mesothelin hYP218 CAR T cells alone, and in combination with ...
Sameer Mir +8 more
doaj +1 more source
Cloud-based microbe analysis pipelines on National Cancer Institute (NCI) cloud resources
, 2017 National Cancer Institute (NCI) Cloud Resources1,2, formerly the NCI Cancer Genomics Cloud Pilots, were developed with the goal of democratizing access to cancer genomic data and facilitating analysis. As a Software-as-a-Service built on commercial cloud architectures, these resources offer the flexibility for users to package their own tools in the ...
openaire +1 more source
Serum concentrations of per- and polyfluorinated substances and risk of B-cell non-Hodgkin lymphoma
Environment InternationalPer- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants that are detectable in the serum of most U.S. adults. Some studies of highly-exposed individuals have suggested positive associations between PFAS and B-cell non-Hodgkin ...
Jongeun Rhee +9 more
doaj +1 more source