Results 91 to 100 of about 884,783 (299)

Re: Prognostic Significance of Digital Rectal Examination and Prostate Specific Antigen in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Arm

Journal of Urological Surgery, 2017
EDITORIAL COMMENT The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial is a large population-based randomized trial designed and sponsored by the National Cancer Institute to determine the effects of screening on cancer-related ...
Özgür Yaycıoğlu
doaj   +1 more source

Quantifying argonaute proteins in and out of GW/P-bodies: Implications in microRNA activities [PDF]

, 2018
MicroRNAs (miRNAs) are a class of ∼22nt non-coding RNAs that regulate the translational potential and stability of mRNAs. Though constituting only 1-4% of human genes, miRNAs are predicted to regulate more than 60% of all mRNAs.
Leung, Anthony K. L., Sharp, Phillip A.
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters [PDF]

, 2010
Transcription of long noncoding RNAs (lncRNAs) within gene regulatory elements can modulate gene activity in response to external stimuli, but the scope and functions of such activity are not known.
A Di Leonardo, A Kanhere, A Subramanian, AC Seila, AM Khalil, Anita Langerød, Anne-Lise Børresen-Dale, Ashley K Koegel, Benjamin Kong, C Bock, C Kosiol, Christopher Umbricht, CJ Sherr, CL Wei, David J Wong, DG Johnson, DJ Wong, E Pasmant, E Segal, F De Santa, G Hutvagner, G Michlewski, GA Calin, Gavin D Grant, Howard Y Chang, Hugo M Horlings, J Han, J Ponjavic, J Taylor, JC Schwartz, JL Rinn, JL Rinn, JM Morachis, JS Mattick, JS Mattick, JT Lee, K Struhl, KP Olive, L He, LJ Core, M Guttman, M Hall, M Huarte, Manolis Kellis, Marc van de Vijver, MC Tsai, MF Lin, MF Lin, Michael F Lin, Michael L Whitfield, MJ van de Vijver, ML Agarwal, ML Whitfield, Nilay Shah, OJ Rando, P Bertone, P Carninci, P Carninci, P Kapranov, Pei Wang, RA Gupta, RJ Taft, S Geisler, S Katayama, Saraswati Sukumar, Seung K Kim, Tiffany Hung, TK Kim, W Yu, X Wang, Yojiro Kotake, Yu Wang, Yue Xiong, Yulei Wang   +73 more
core   +3 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data [PDF]

, 2013
How DNA is organized in three dimensions inside the cell nucleus and how this affects the ways in which cells access, read and interpret genetic information are among the longest standing questions in cell biology.
Dekker, Job, Marti-Renom, Marc A., Mirny, Leonid A.   +2 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Plasma membrane recovery kinetics of a microfluidic intracellular delivery platform [PDF]

, 2013
Intracellular delivery of materials is a challenge in research and therapeutic applications. Physical methods of plasma membrane disruption have recently emerged as an approach to facilitate the delivery of a variety of macromolecules to a range of cell ...
Cho, Nahyun, Eyerman, Alexandra T., Hartoularos, George C., Jackson, Emily L., Jang, Derek Y., Jensen, Klavs F, Jhunjhunwala, Siddharth, Langer, Robert S, Mao, Shirley, Poceviciute, Roberta, Schoettle, Taylor, Sharei, Armon Reza   +11 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

MicroRNAs can generate thresholds in target gene expression [PDF]

, 2010
MicroRNAs (miRNAs) are short, highly conserved noncoding RNA molecules that repress gene expression in a sequence-dependent manner. We performed single-cell measurements using quantitative fluorescence microscopy and flow cytometry to monitor a target ...
A Arvey, A Cimmino, A Grimson, A Raj, A Stark, Alexander van Oudenaarden, BP Lewis, C Mayr, D Baek, E Bernstein, E Levine, Grace X Y Zheng, H Guo, J Elf, JM Calabrese, John S Tsang, JPG Sluijter, JS Tsang, KK Farh, L Poliseno, LP Lim, M Selbach, Margaret S Ebert, MS Ebert, MS Ebert, N Buchler, Phillip A Sharp, R Yi, RC Friedman, S Bagga, Shankar Mukherji, X Li, X Li, Y Li   +33 more
core   +1 more source