Results 101 to 110 of about 884,783 (299)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Adapting and Operationalizing the RE-AIM Framework for Implementation Science in Environmental Health: Clean Fuel Cooking Programs in Low Resource Countries

Frontiers in Public Health, 2019
Introduction: The use of models and frameworks to design and evaluate strategies to improve delivery of evidence-based interventions is a foundational element of implementation science.
Ashlinn K. Quinn, Gila Neta, Rachel Sturke, Christopher O. Olopade, Suzanne L. Pollard, Kenneth Sherr, Joshua P. Rosenthal   +6 more
doaj   +1 more source

Structure-based programming of lymph-node targeting in molecular vaccines [PDF]

, 2014
In cancer patients, visual identification of sentinel lymph nodes (LNs) is achieved by the injection of dyes that bind avidly to endogenous albumin, targeting these compounds to LNs, where they are efficiently filtered by resident phagocytes1, 2. Here we
Adrienne V. Li, AL St John, AM Krieg, BE Schaafsma, Bonnie Huang, C Bode, C Bourquin, C Tsopelas, Clara Park, Darrell J. Irvine, Debra S. Van Egeren, DH Barouch, GG Kenter, Gregory L. Szeto, H Liu, Haipeng Liu, I Pal, J Vollmer, JA Hubbell, JJ Moon, Kelly D. Moynihan, M Kastantin, M Salhab, M Tenbusch, MB Faries, MC Feltkamp, MF Bachmann, ML De Temmerman, MW Schreurs, P Johansen, RK Gupta, ST Reddy, T Keler, T Peters, VS Trubetskoy, W Zeng, Yiran Zheng   +36 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Returning to scientific operations at GM/CA@APS after the APS-Upgrade [PDF]

Structural Dynamics
The Advanced Photon Source (APS) underwent a comprehensive upgrade to replace the original electron storage ring with a new storage ring (APS-U) that increased the X-ray brightness by up to 500 times compared to the APS. The National Institute of General
David J Kissick, Michael Becker, Stephen Corcoran, Dale Ferguson, Mark Hilgart, Oleg Makarov, Sergey Stepanov1, Nagarajan Venugopalan, Qingping Xu, Shenglan Xu, Janet L Smith, Robert F Fischetti   +11 more
doaj   +1 more source

Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters [PDF]

, 2013
The extracellular matrix (ECM) is a major component of tumors and a significant contributor to cancer progression. In this study, we use proteomics to investigate the ECM of human mammary carcinoma xenografts and show that primary tumors of differing ...
Anastassiades, Barry-Hamilton, Bergamaschi, Berra, Boudreau, Bulk, Cailleau, Chauhan, Chen, Comen, Conklin, Conklin, Curran, Dvorak, Egeblad, Erler, Finak, Fordyce, Geiger, Gillette, Goodman, Gygi, Györffy, Hynes, Hynes, Hynes, Jacobetz, Joyce, Klotzsche-von Ameln, Korpal, Lamar, Lamprecht, Leimeister, Massague, Minn, Minn, Munger, Naba, Padua, Padua, Paget, Pasche, Polyak, Ramirez, Rappsilber, Ribatti, Ryan, Sevenich, Sevenich, Stern, Tchou, Tlsty, Todorovic, Tsai, Tsai, Vasiljeva, Whatcott, Wilson, Yuan   +58 more
core   +2 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

EGFRvIV: a previously uncharacterized oncogenic mutant reveals a kinase autoinhibitory mechanism [PDF]

, 2010
Tumor cells often subvert normal regulatory mechanisms of signal transduction. This study shows this principle by studying yet uncharacterized mutants of the epidermal growth factor receptor (EGFR) previously identified in glioblastoma multiforme, which ...
AJ Ekstrand, AJ Wong, AW Burgess, CT Kuan, DB Ramnarain, E Tzahar, ER Wood, F Chiara, F M White, G Chiosis, G Getz, G Pines, HK Gan, HK Shu, J Jeuken, J Stamos, J Wykosky, JJ Li, JP Dawson, K Shtiegman, L Frederick, LM Shewchuk, M Katz, M Ladanyi, M Landau, M Nagane, MJ McManus, N Gotoh, N Jura, NE Hynes, P H Huang, PH Huang, PH Huang, R Zenz, RW Clarkson, S Hafizi, S Pulciani, SJ Lavictoire, T Shimamura, WG An, X Zhang, Y Yarden, Y Zhang, Y Zwang   +43 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Effects of thymic selection of the T cell repertoire on HLA-class I associated control of HIV infection [PDF]

, 2009
Without therapy, most people infected with human immunodeficiency virus (HIV) ultimately progress to AIDS. Rare individuals (‘elite controllers’) maintain very low levels of HIV RNA without therapy, thereby making disease progression and transmission ...
A Košmrlj, A Košmrlj, Andrej Košmrlj, Arup K. Chakraborty, B Peters, B Peters, B Peters, Bruce D. Walker, CL Althaus, CL Thio, D Chessman, D Naeher, D Wodarz, DA Price, DL Chao, DW Hosmer, EL Turnbull, Elizabeth L. Read, ES Huseby, ES Huseby, F Pereyra, Florencia Pereyra, GM Gillespie, H Streeck, J Bhalerao, JA López de Castro, JH Cao, JJ Moon, JM Cheverud, K Gulukota, M Altfeld, M Parera, MA Nowak, MA Stafford, Marcus Altfeld, Mary Carrington, N Sachsenberg, P Bowness, P Kiepiela, S Miyazawa, SA Migueles, SG Deeks, SM McKiernan, Steven G. Deeks, TJ Hubbard, Todd M. Allen, X Jin, X Rao, XG Yu, Ying Qi   +49 more
core   +3 more sources