Results 121 to 130 of about 884,783 (299)

Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles [PDF]

, 2019
We sought to develop a nanoparticle vehicle that could efficiently deliver small molecule drugs to target lymphocyte populations. The synthesized amphiphilic organic ligand-protected gold nanoparticles (amph-NPs) were capable of sequestering large ...
Bekdemir, Ahmet, Dichwalkar, Tanmay M, Ingram, Jessica, Irvine, Darrell J, Melo, Mariane Bandeira, Moynihan, Kelly Dare, Noh, Michelle M., Ploegh, Hidde, Stellacci, Francesco R., Suh, Heikyung, Watson, Nicki, Yang, Yu-Sang Sabrina   +11 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Biomedical research and dissemination: The value of global collaborations

Journal of the National Cancer Center, 2021
Barnett S. Kramer, Min Dai, Margaret Beckwith, Ping Hu, Ni Li, Jiansong Ren, Martina Taylor, Jie He   +7 more
doaj   +1 more source

Observer Performance in the Use of Digital and Optical Microscopy for the Interpretation of Tissue-Based Biomarkers

Analytical Cellular Pathology, 2014
Background. We conducted a validation study of digital pathology for the quantitative assessment of tissue-based biomarkers with immunohistochemistry. Objective.
Marios A. Gavrielides, Catherine Conway, Neil O’Flaherty, Brandon D. Gallas, Stephen M. Hewitt   +4 more
doaj   +1 more source

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence [PDF]

, 2014
Background Cancers arise from multiple acquired mutations, which presumably occur over many years. Early stages in cancer development might be present years before cancers become clinically apparent.
Bakhoum, Samuel F., Chambert, Kimberly, Fromer, Menachem, Gabriel, Stacey B., Genovese, Giulio, Gronberg, Henrik, Handsaker, Robert E., Hoglund, Martin, Hultman, Christina M., Kahler, Anna K., Landen, Mikael, Lander, Eric S., Lehmann, Soren, Lindberg, Johan, McCarroll, Steven A., Mick, Eran, Moran, Jennifer L., Neale, Benjamin M., Purcell, Shaun M., Rose, Samuel A., Sklar, Pamela, Sullivan, Patrick F., Svantesson, Oscar   +22 more
core   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Microfluidic Platform for Combinatorial Synthesis and Optimization of Targeted Nanoparticles for Cancer Therapy [PDF]

, 2013
Taking a nanoparticle (NP) from discovery to clinical translation has been slow compared to small molecules, in part by the lack of systems that enable their precise engineering and rapid optimization.
Farokhzad, Omid C., Karnik, Rohit, Langer, Robert, Pridgen, Eric M., Rhee, Minsoung, Valencia, Pedro M.   +5 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Viewing RNA-seq data on the entire human genome [version 1; referees: 3 approved]

F1000Research, 2017
RNA-Seq Viewer is a web application that enables users to visualize genome-wide expression data from NCBI’s Sequence Read Archive (SRA) and Gene Expression Omnibus (GEO) databases.
Eric M. Weitz, Lorena Pantano, Jingzhi Zhu, Bennett Upton, Ben Busby   +4 more
doaj   +1 more source

Global microRNA depletion suppresses tumor angiogenesis [PDF]

, 2014
MicroRNAs delicately regulate the balance of angiogenesis. Here we show that depletion of all microRNAs suppresses tumor angiogenesis. We generated microRNA-deficient tumors by knocking out Dicer1. These tumors are highly hypoxic but poorly vascularized,
Bell, Eric L., Bhutkar, Arjun (AJ), Chen, Sidi, Langer, Robert, Le, Cong, Sharp, Phillip A., Wu, Xuebing, Ph. D. Massachusetts Institute of Technology, Wu, Xuebing, Ph. D. Massachusetts Institute of Technology, Xue, Yuan, Zhang, Feng   +9 more
core   +1 more source