Results 11 to 20 of about 884,783 (299)

AIDS and Cancer Specimen Resource (ACSR)

Open Journal of Bioresources, 2018
The AIDS and Cancer Specimen Resource (ACSR) has four regional biorepositories (RBRs) in the United States and one in South Africa. The ACSR is funded by the National Cancer Institute (NCI) of the National Institutes of Health (United States) to support ...
Sylvia Silver, Jeffrey Bethony, Piage Bracci, Ashokkumar A. Patel, Mostafa Nokta, Michael Ittmann, Lisa Rimza, Johann Schneider, Michael McGrath   +8 more
doaj   +1 more source

BrainPrint: A discriminative characterization of brain morphology [PDF]

, 2015
We introduce BrainPrint, a compact and discriminative representation of brain morphology. BrainPrint captures shape information of an ensemble of cortical and subcortical structures by solving the eigenvalue problem of the 2D and 3D Laplace–Beltrami ...
Fischl, Bruce, Golland, Polina, Kremen, William, Reuter, Klaus Martin, Wachinger, Christian   +4 more
core   +4 more sources

A Nanoparticle Size Series for In Vivo Fluorescence Imaging [PDF]

, 2010
A nanoparticle toolset was created within the size limits of 10–150 nm for probing size-dependent nanoparticle distribution in solid tumors. By using multiphoton intravital microscopy, the particles were tracked both spatially and temporally in the same ...
Bruchez, Butterworth, Chauhan, Choi, Farokhzad, Hobbs, Insin, Jain, Koole, Larsen, Liu, Liu, Magzoub, Meng, Nel, Netti, Perrault, Pons, Sarin, Stroh, Tyrrell, Yuan, Zhuang, Zhuang   +23 more
core   +1 more source

Organocatalyst treatment improves variant calling and mutant detection in archival clinical samples

Scientific Reports, 2022
Formalin fixation of biological specimens damages nucleic acids and limits their use in genomic analyses. Previously, we showed that RNA isolation with an organocatalyst (2-amino-5-methylphenyl phosphonic acid, used to speed up reversal of formalin ...
Leah C. Wehmas, Charles E. Wood, Ping Guan, Mark Gosink, Susan D. Hester   +4 more
doaj   +1 more source

Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype [PDF]

, 2013
We demonstrate CRISPR-Cas9–mediated correction of a Fah mutation in hepatocytes in a mouse model of the human disease hereditary tyrosinemia. Delivery of components of the CRISPR-Cas9 system by hydrodynamic injection resulted in initial expression of the
Anderson, Daniel Griffith, Benedetti, Eric, Bogorad, Roman, Chen, Sidi, Grompe, Markus, Jacks, Tyler E, Kotelianski, Victor E., Sharp, Phillip A., Xue, Wen, Yin, Hao   +9 more
core   +1 more source

Measuring single cell mass, volume, and density with dual suspended microchannel resonators [PDF]

, 2013
Cell size, measured as either volume or mass, is a fundamental indicator of cell state. Far more tightly regulated than size is density, the ratio between mass and volume, which can be used to distinguish between cell populations even when volume and ...
Bryan, Andrea Kristine, Grover, William H., Hecht, Vivian Chaya, Manalis, Scott R, Payer, Kristofor Robert, Shen, Wenjiang   +5 more
core   +1 more source

Informatics research using publicly available pathology data

Journal of Pathology Informatics, 2011
The day has not arrived when pathology departments freely distribute their collected anatomic and clinical data for research purposes. Nonetheless, several valuable public domain data sets are currently available, from the U.S. Government.
Jules J Berman
doaj   +1 more source

Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression [PDF]

, 2018
The epithelial-mesenchymal transition (EMT) program has emerged as a central driver of tumor malignancy. Moreover, the recently uncovered link between passage through an EMT and acquisition of stem-like properties indicates that activation of the EMT ...
Weinberg, Robert A, Ye, Xin
core   +1 more source

Hybrid Molecules Containing a 7-Chloro-4-aminoquinoline Nucleus and a Substituted 2-Pyrazoline with Antiproliferative and Antifungal Activity

Molecules, 2016
Twenty-four new hybrid analogues (15–38) containing 7-chloro-4-aminoquinoline and 2-pyrazoline N-heterocyclic fragments were synthesized. Twelve of the new compounds were evaluated against 58 human cancer cell lines by the U.S. National Cancer Institute (
Alba Montoya, Jairo Quiroga, Rodrigo Abonia, Marcos Derita, Maximiliano Sortino, Alfredo Ornelas, Susana Zacchino, Braulio Insuasty   +7 more
doaj   +1 more source

The Carcinogenic Potency Database: Analyses of 4000 Chronic Animal Cancer Experiments Published in the General Literature and by the U.S. National Cancer Institute/National Toxicology Program [PDF]

Environmental Health Perspectives, 1991
The Carcinogenic Potency Database (CPDB) is an easily accessible, standardized resource of positive and negative long-term animal cancer tests. The CPDB has been published in four earlier papers that include results for approximately 4000 experiments on 1050 chemicals. This paper describes the CPDB: goals, inclusion criteria, fields of information, and
L S, Gold, T H, Slone, N B, Manley, G B, Garfinkel, E S, Hudes, L, Rohrbach, B N, Ames   +6 more
openaire   +2 more sources