Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure [PDF]
, 2015 Failure of the human heart to maintain sufficient output of blood for the demands of the body, heart failure, is a common condition with high mortality even with modern therapeutic alternatives. To identify molecular determinants of mortality in patients
Boyer, Laurie Ann +2 more
core +1 more source
Clinical Outcome Assessments Toolbox for Radiopharmaceuticals
Frontiers in Oncology, 2019 For nearly 40 years, the U.S. National Cancer Institute (NCI) has funded health-related quality-of-life (HRQOL) and symptom management in oncology clinical trials as a method for including a cancer patient's experience during and after treatment. The NCI'
Charles A. Kunos +5 more
doaj +1 more source
Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels [PDF]
, 2013 Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to solid stress, with hyaluronan implicated as the primary matrix ...
Adstamongkonkul, Pichet +14 more
core +1 more source
Nanoparticle amplification via photothermal unveiling of cryptic collagen binding sites [PDF]
, 2013 The success of nanoparticle-based cancer therapies ultimately depends on their ability to selectively and efficiently accumulate in regions of disease.
Armstrong +24 more
core +1 more source
Prostate Cancer Incidence Rates in Africa
Prostate Cancer, 2011 African American men have among the highest prostate cancer incidence rates in the world yet rates among their African counterparts are unclear. In this paper, we compared reported rates among black men of Sub-Saharan African descent using data from the ...
Lisa W. Chu +5 more
doaj +1 more source
Dutch translation and linguistic validation of the U.S. National Cancer Institute’s Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE™) [PDF]
Journal of Patient-Reported Outcomes, 2020 Abstract Background The U.S. National Cancer Institute’s Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE™) is a library of items for assessing symptomatic adverse events by patient self-report in oncology trials.
Evalien Veldhuijzen +8 more
openaire +5 more sources
Small RNA combination therapy for lung cancer [PDF]
, 2014 MicroRNAs (miRNAs) and siRNAs have enormous potential as cancer therapeutics, but their effective delivery to most solid tumors has been difficult. Here, we show that a new lung-targeting nanoparticle is capable of delivering miRNA mimics and siRNAs to ...
Anderson, Daniel Griffith +15 more
core +1 more source
Cooperative nanoparticles for tumor detection and photothermally triggered drug delivery [PDF]
, 2009 Author Manuscript: 2011 March 15.A cooperative nanosystem consisting of two distinct nanomaterials works in vivo to detect tumor tissues and deliver drugs to the site.
Cummings +28 more
core +1 more source
Understanding the Intersections between Metabolism and Cancer Biology [PDF]
, 2017 Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of transformation or support the biological processes that enable tumor growth.
DeBerardinis, Ralph J. +1 more
core +1 more source
Functional categories associated with clusters of genes that are co-expressed across the NCI-60 cancer cell lines. [PDF]
PLoS ONE, 2012 The NCI-60 is a panel of 60 diverse human cancer cell lines used by the U.S. National Cancer Institute to screen compounds for anticancer activity.
Barry R Zeeberg +6 more
doaj +1 more source