Results 31 to 40 of about 884,783 (299)

Treating non-responders: pitfalls and implications for cancer immunotherapy trial design

Journal of Hematology & Oncology, 2020
Background Conventional trial design and analysis strategies fail to address the typical challenge of immune-oncology (IO) studies: only a limited percentage of treated patients respond to the experimental treatment.
Zhenzhen Xu, Yongsoek Park, Ke Liu, Bin Zhu   +3 more
doaj   +1 more source

Breast cancer subtype and survival among Indigenous American women in Peru. [PDF]

PLoS ONE, 2018
Latina women in the U.S. have relatively low breast cancer incidence compared to Non-Latina White (NLW) or African American women but are more likely to be diagnosed with the more aggressive "triple negative" breast cancer (TNBC). Latinos in the U.S. are
Lizeth I Tamayo, Tatiana Vidaurre, Jeannie Navarro Vásquez, Sandro Casavilca, Jessica I Aramburu Palomino, Monica Calderon, Julio E Abugattas, Henry L Gomez, Carlos A Castaneda, Sikai Song, Daniel Cherry, Garth H Rauscher, Laura Fejerman   +12 more
doaj   +1 more source

A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α [PDF]

, 2012
Emerging evidence points to aberrant regulation of translation as a driver of cell transformation in cancer. Given the direct control of translation by tRNA modifications, tRNA modifying enzymes may function as regulators of cancer progression.
Aguirre-Ghiso, Julio A., Avivar-Valderas, Alvaro, Begley, Thomas J., Begley, Ulrike, Chan, Tsz Yan Clement, Dedon, Peter C., Endres, Lauren, Estrada, Yeriel, Patil, Ashish, Sosa, Maria Soledad, Su, Dan   +10 more
core   +1 more source

Investigation of Relationships Between the Geospatial Distribution of Cancer Incidence and Estimated Pesticide Use in the U.S. West

GeoHealth, 2022
The objective of the study was to evaluate the potential geospatial relationship between agricultural pesticide use and two cancer metrics (pediatric cancer incidence and total cancer incidence) across each of the 11 contiguous states in the Western ...
Naveen Joseph, Catherine R. Propper, Madeline Goebel, Shantel Henry, Indrakshi Roy, Alan S. Kolok   +5 more
doaj   +1 more source

Operationalizing Leadership and Clinician Buy-In to Implement Evidence-Based Tobacco Treatment Programs in Routine Oncology Care: A Mixed-Method Study of the U.S. Cancer Center Cessation Initiative

Current Oncology, 2022
Background: Delivering evidence-based tobacco dependence treatment in oncology settings improves smoking abstinence and cancer outcomes. Leadership engagement/buy-in is critical for implementation success, but few studies have defined buy-in or described
Sarah D. Hohl, Jennifer E. Bird, Claire V. T. Nguyen, Heather D’Angelo, Mara Minion, Danielle Pauk, Robert T. Adsit, Michael Fiore, Margaret B. Nolan, Betsy Rolland   +9 more
doaj   +1 more source

An improved method for large-scale preparation of negatively and positively supercoiled plasmid DNA [PDF]

, 2008
A rigorous understanding of the biological function of superhelical tension in cellular DNA requires the development of new tools and model systems for study.
Ausubel F.M., Debra A. Dederich, Forterre P., Funnell B.E., Marita C. Barth, Peter C. Dedon   +5 more
core   +1 more source

Ensemble Deep Learning for Cervix Image Selection toward Improving Reliability in Automated Cervical Precancer Screening

Diagnostics, 2020
Automated Visual Examination (AVE) is a deep learning algorithm that aims to improve the effectiveness of cervical precancer screening, particularly in low- and medium-resource regions.
Peng Guo, Zhiyun Xue, Zac Mtema, Karen Yeates, Ophira Ginsburg, Maria Demarco, L. Rodney Long, Mark Schiffman, Sameer Antani   +8 more
doaj   +1 more source

Sugar-sweetened beverage intake and cancer recurrence and survival in CALGB 89803 (Alliance). [PDF]

PLoS ONE, 2014
BACKGROUND:In colon cancer patients, obesity, sedentary lifestyle, and high dietary glycemic load have been associated with increased risk of cancer recurrence.
Michael A Fuchs, Kaori Sato, Donna Niedzwiecki, Xing Ye, Leonard B Saltz, Robert J Mayer, Rex B Mowat, Renaud Whittom, Alexander Hantel, Al Benson, Daniel Atienza, Michael Messino, Hedy Kindler, Alan Venook, Shuji Ogino, Kana Wu, Walter C Willett, Edward L Giovannucci, Jeffrey A Meyerhardt   +18 more
doaj   +1 more source

An In Vitro Assessment of Immunostimulatory Responses to Ten Model Innate Immune Response Modulating Impurities (IIRMIs) and Peptide Drug Product, Teriparatide

Molecules, 2021
Understanding, predicting, and minimizing the immunogenicity of peptide-based therapeutics are of paramount importance for ensuring the safety and efficacy of these products. The so-called anti-drug antibodies (ADA) may have various clinical consequences,
Claire K. Holley, Edward Cedrone, Duncan Donohue, Barry W. Neun, Daniela Verthelyi, Eric S. Pang, Marina A. Dobrovolskaia   +6 more
doaj   +1 more source

How vision and leadership shaped the U.S. National Cancer Institute's 50-year journey to advance the evidence base of cancer control and cancer care delivery research

Health Policy OPEN, 2020
In 1971, Congress passed the National Cancer Act, landmark legislation that reorganized the National Institutes of Health's National Cancer Institute (NCI). The Act included a new focus on cancer control, including the requirement that the NCI award research grants and contracts, in collaboration with other public agencies and private industry, to ...
Arnold D. Kaluzny, Donna M. O'Brien
openaire   +3 more sources