Results 51 to 60 of about 884,783 (299)
Molecules, 2016 With the aim of developing novel antitumor scaffolds, a novel series of polysubstituted pyrazole derivatives linked to different nitrogenous heterocyclic ring systems at the C-4 position were synthesized through different chemical reactions and ...
Hoda H. Fahmy +4 more
doaj +1 more source
A Landscape Analysis of U.S. National Cancer Institute's Cancer Stigma Research Portfolio
Journal of Global Oncology, 2018 Background: Successful characterization of cancer stigma among various populations has the potential to inform effective interventions targeted at combatting the social ignominy. Instances of social discrediting range from misconceptions about cancer treatment that prevent early detection to biases due to physical changes of cancer survivors, such as ...
openaire +1 more source
Rapid Access to Preventive Intervention Development Program in the Division of Cancer Prevention of the U.S. National Cancer Institute: an Overview [PDF]
Cancer Epidemiology, Biomarkers & Prevention, 2009 As a 17th century English preacher stated: “Prevention is much better than healing because it saves the labor of being sick” (T. Adams, The Happiness of Church , 1618, p146). The term “chemoprevention” was coined by Sporn and coworkers in the 1970s ([1][1]) and articulated through ...
openaire +2 more sources
Exploiting synthetic lethal interactions for targeted cancer therapy [PDF]
, 2009 March 15, 2011Emerging data suggests that synthetic lethal interactions between mutated oncogenes/tumor suppressor genes and molecules involved in DNA damage signaling and repair can be therapeutically exploited to preferentially kill tumor cells.
Hemann, Michael +3 more
core +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction Characterizing stressful events reported by childhood cancer survivors experienced throughout the lifespan may help improve trauma‐informed care relevant to the survivor experience. Methods Participants included 2552 survivors (54% female; 34 years of age) and 469 community controls (62% female; 33 years of age) from the St.
Megan E. Ware +13 more
wiley +1 more source
Molecules, 2015 A series of new 3-amino-6-chloro-7-(azol-2 or 5-yl)-1,1-dioxo-1,4,2-benzodithiazine derivatives 5a–j have been synthesized and evaluated in vitro for their antiproliferative activity at the U.S. National Cancer Institute.
Aneta Pogorzelska +4 more
doaj +1 more source
A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis [PDF]
, 2012 Extracellular matrix interactions have essential roles in normal physiology and many pathological processes. Although the importance of extracellular matrix interactions in metastasis is well documented, systematic approaches to identify their roles in ...
A Albini +47 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Primary lung carcinomas and bronchial carcinoid tumors (BC) are very rare malignancies in childhood. While typical BC and mucoepidermoid carcinomas are mostly low‐grade, localized tumors with a more favorable prognosis than in adults, necessitating avoidance of overtreatment, adenocarcinomas of the lung are often diagnosed at advanced disease ...
Michael Abele +19 more
wiley +1 more source
Frontiers in Oncology, 2018 Women in the U.S. Commonwealth of Puerto Rico (PR) have a higher age-adjusted incidence rate for uterine cervix cancer than the U.S. mainland as well as substantial access and economic barriers to cancer care.
Charles A. Kunos +6 more
doaj +1 more source
A Nanoparticle-Based Combination Chemotherapy Delivery System for Enhanced Tumor Killing by Dynamic Rewiring of Signaling Pathways [PDF]
, 2014 Exposure to the EGFR (epidermal growth factor receptor) inhibitor erlotinib promotes the dynamic rewiring of apoptotic pathways, which sensitizes cells within a specific period to subsequent exposure to the DNA-damaging agent doxorubicin.
Deng, Zhou J. +8 more
core +1 more source