Results 61 to 70 of about 884,783 (299)

Results of the Childhood Cancer and Leukaemia Group's United Kingdom Relapsed Wilms Tumour Trial

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The United Kingdom relapsed Wilms tumour (UKW‐R) trial aimed to improve the historically low survival rates after relapse of Wilms tumour (WT) through a prospective national risk‐stratified protocol. The trial also evaluated efficacy and toxicity of high‐dose melphalan.
Sucheta J. Vaidya, Veronica Moroz, Juliet Hale, Vesna Pavasovic, Rachel Hobson, Patricia Sartori, Daniel Saunders, Mark Powis, Gordan M. Vujanic, Stephen Baker, Kathy Pritchard‐Jones   +10 more
wiley   +1 more source

High-throughput functional genomics using CRISPR–Cas9 [PDF]

, 2015
Forward genetic screens are powerful tools for the discovery and functional annotation of genetic elements. Recently, the RNA-guided CRISPR (clustered regularly interspaced short palindromic repeat)-associated Cas9 nuclease has been combined with genome ...
Sanjana, Neville, Shalem, Ophir, Zhang, Feng   +2 more
core   +1 more source

Exploring Preferences for a Digital Single‐Session Intervention for Adolescent Siblings of Youth With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Adolescent siblings of children with cancer are at elevated risk for psychosocial problems. Unfortunately, various barriers such as limited family time and resources, conflicting schedules, and psychosocial staffing constraints at cancer centers hinder sibling access to support.
Christina M. Amaro, Sarah Silver, Prishi Patel, Meredith K. Reffner Collins, Kimberly S. Canter, Stephanie Fooks‐Parker, Michael Amylon, Shawna V. Hudson, Jessica L. Schleider, Melissa A. Alderfer, Katie A. Devine   +10 more
wiley   +1 more source

JAK2/IDH-mutant–driven myeloproliferative neoplasm is sensitive to combined targeted inhibition [PDF]

, 2018
Patients with myeloproliferative neoplasms (MPNs) frequently progress to bone marrow failure or acute myeloid leukemia (AML), and mutations in epigenetic regulators such as the metabolic enzyme isocitrate dehydrogenase (IDH) are associated with poor ...
Alan H. Shih, Allison N. Lau, Amritha Varshini Hanasoge Somasundara, Andrew M. Intlekofer, Anna Sophia McKenney, April Chiu, Barbara Spitzer, Craig B. Thompson, Efthymia Papalexi, Elizaveta Freinkman, Esra A. Akbay, Franck T. Rapaport, Gaujoux, Jihae Ahn, Julie Teruya-Feldstein, Kaitlyn Shank, Katharine Yen, Kwok-Kin Wong, Matthew G. Vander Heiden, Mesa, Minal A. Patel, Mya Steadman, Raajit Rampal, Raj Nagaraja, Ross L. Levine, Stein, Tefferi   +26 more
core   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Crosstalk between tumour and stroma modifies CLIC4 cargo in extracellular vesicles

Journal of Extracellular Biology, 2023
Mouse models of breast cancer have revealed that tumour‐bearing hosts must express the oxidoreductase CLIC4 to develop lung metastases. In the absence of host CLIC4, primary tumours grow but the lung premetastatic niche is defective for metastatic ...
Vanesa C. Sanchez, Alayna Craig‐Lucas, Christophe Cataisson, Brandi L. Carofino, Stuart H. Yuspa   +4 more
doaj   +1 more source

An Overview of the U.S. National Cancer Institute's (NCI) 2023 International Research Portfolio

JCO Global Oncology
PURPOSE As part of its goal to represent NCI and promote its engagement with international partners, the NCI Center for Global Health (CGH) conducts an annual analysis of NCI's international research portfolio, which includes NCI-funded extramural grants and NCI intramural projects with principal investigators (PIs) or collaborators at institutions ...
Tosca Le, Elise M. Garton
openaire   +1 more source

Cas9 gRNA engineering for genome editing, activation and repression [PDF]

, 2015
We demonstrate that by altering the length of Cas9-associated guide RNA(gRNA) we were able to control Cas9 nuclease activity and simultaneously perform genome editing and transcriptional regulation with a single Cas9 protein.
A Chavez, Alejandro Chavez, B Chen, B Li, Benjamin W Pruitt, CW Law, Dmitry Ter-Ovanesyan, Emma J K Kowal, George Church, GK Smyth, H Li, H Li, J Beal, Jacob Beal, James J Collins, Jason Qian, JD Sander, Joanna Buchthal, KM Esvelt, L Nissim, LE Dow, LS Qi, Marcelle Tuttle, ML Maeder, Mohammad R Ebrahimkhani, N Davidsohn, P Mali, P Perez-Pinera, PD Hsu, RA Hoffman, Raj Chari, Richard N Hall, RJ Platt, Ron Weiss, S Kiani, Samira Kiani, Suhani Vora, T Magoč, W Jiang, Y Fu, Y Li   +40 more
core   +2 more sources

Efficacy and Tolerability of Topotecan/Cyclophosphamide/Dinutuximab in Relapsed and Refractory High‐Risk Neuroblastoma: A Multi‐Institutional Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Chemoimmunotherapy with irinotecan, temozolomide, and dinutuximab (I/T/DIN) has emerged as first‐line therapy for relapsed/refractory (r/r) high‐risk neuroblastoma (HRNB) in North America. Topotecan and cyclophosphamide (T/C) are often used in combination with dinutuximab in the setting of lack of response, progression, or incomplete ...
Benjamin J. Lerman, Madeleine King, Rajen Mody, Sara‐Jane Onyeama, Araz Marachelian, Thomas Cash, Sara M. Federico, Meaghan Granger, Ami V. Desai, Suzanne Shusterman, Jennifer H. Foster, Elizabeth Sokol, Chelsee Greer, Keri Streby, Holly J. Meany, Kieuhoa T. Vo, Margaret E. Macy, Rochelle Bagatell   +17 more
wiley   +1 more source

Imaging Modalities in Inflammatory Breast Cancer (IBC) Diagnosis: A Computer-Aided Diagnosis System Using Bilateral Mammography Images

Sensors, 2022
Inflammatory breast cancer (IBC) is an aggressive type of breast cancer. It leads to a significantly shorter survival than other types of breast cancer in the U.S.
Buket D. Barkana, Ahmed El-Sayed, Rana H. Khaled, Maha Helal, Hussein Khaled, Ruba Deeb, Mark Pitcher, Ruth Pfeiffer, Marilyn Roubidoux, Catherine Schairer, Amr S. Soliman   +10 more
doaj   +1 more source