Results 81 to 90 of about 884,783 (299)

Danish Translation and Linguistic Validation of the U.S. National Cancer Institute's Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) [PDF]

Journal of Pain and Symptom Management, 2016
Context The Common Terminology Criteria for Adverse Events (CTCAE) is the basis for standardized clinician-based grading and reporting of adverse events in cancer clinical trials. The U.S. National Cancer Institute has developed the Patient-Reported Outcomes version of the CTCAE (PRO-CTCAE) to incorporate patient self-reporting of symptomatic adverse ...
Bæksted, Christina, Nissen, Aase, Pappot, Helle, Bidstrup, Pernille Envold, Mitchell, Sandra A, Basch, Ethan, Dalton, Susanne Oksbjerg, Johansen, Christoffer   +7 more
openaire   +3 more sources

Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells [PDF]

, 2014
Bacterial type II CRISPR-Cas9 systems have been widely adapted for RNA-guided genome editing and transcription regulation in eukaryotic cells, yet their in vivo target specificity is poorly understood.
A Orioli, Albert W Cheng, Alexandro E Trevino, Andrea J Kriz, Anthony C Chiu, AW Cheng, B Chen, B Langmead, D Carroll, Daniel B Dadon, David A Scott, DJ Dickinson, DP Bartel, Feng Zhang, FJM Mojica, G Gasiunas, G Schwank, GE Crooks, H Chiu, H Deveau, H Nishimasu, J van der Oost, JA Stamatoyannopoulos, L Cong, L Teytelman, LA Gilbert, LA Marraffini, LS Qi, M Jinek, M Jinek, M Jinek, M Jinek, MB Stadler, MJ Packer, ML Maeder, MP Terns, O Shalem, P Horvath, P Machanick, P Mali, P Mali, P Mali, P Perez-Pinera, Patrick D Hsu, PD Hsu, Phillip A Sharp, Rudolf Jaenisch, S Nielsen, SH Sternberg, Sidi Chen, Silvana Konermann, SW Cho, T Wang, TJ Cradick, V Pattanayak, W Jiang, Xuebing Wu, Y Fu, Y Wu, Y Zhang   +59 more
core   +2 more sources

Cognitive Functioning in Vorinostat‐Treated Pediatric and Young Adult Patients Over the First 180 Days After Hematopoietic Stem Cell Transplant

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Cognitive and psychological difficulties could negatively interfere with treatment adherence and quality of life before and after hematopoietic stem cell transplant (HSCT). Methods to mitigate these changes may have positive effects on treatment success.
Kristen L. Votruba, Michelle Rozwadowski, Thomas Braun, April Rahrig, Edward Peres, Kirsten M. Williams, Vanessa Fabrizio, Julie‐An Talano, Carrie L. Kitko, Nicolas Parnell, Pavan Reddy, Sung Won Choi   +11 more
wiley   +1 more source

Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells? [PDF]

, 2018
Cancer stem cells (CSCs) are similar to normal stem cells in their ability to self-renew and to generate large populations of more differentiated descendants.
Scheel, Christina, Weinberg, Robert A
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Immunological and molecular features of the tumor microenvironment of long-term survivors of ovarian cancer

The Journal of Clinical Investigation
BACKGROUND Despite an overall poor prognosis, about 15% of patients with advanced-stage tubo-ovarian high-grade serous carcinoma (HGSC) survive 10 or more years after standard treatment.METHODS We evaluated the tumor microenvironment of this exceptional,
Brad H. Nelson, Phineas Hamilton, Minh Tung Phung, Katy Milne, Bronwyn Harris, Shelby Thornton, Donald Stevens, Shreena Kalaria, Karanvir Singh, Céline M. Laumont, Elena Moss, Aliya Alimujiang, Nicola S. Meagher, Adelyn Bolithon, Sian Fereday, Catherine J. Kennedy, Joy Hendley, Dinuka Ariyaratne, Kathryn Alsop, Nadia Traficante, Ellen L. Goode, Anthony Karnezis, Hui Shen, Jean Richardson, Cindy McKinnonDeurloo, Anne Chase, Bronwyn Grout, Jennifer Anne Doherty, Holly R. Harris, Kara L. Cushing-Haugen, Michael Anglesio, Karolin Heinze, David Huntsman, Aline Talhouk, Gillian E. Hanley, Jennifer Alsop, Mercedes Jimenez-Linan, Paul D.P. Pharoah, Jessica Boros, Alison H. Brand, Paul R. Harnett, Raghwa Sharma, Jonathan L. Hecht, Naoko Sasamoto, Kathryn L. Terry, Beth Karlan, Jenny Lester, Michael E. Carney, Marc T. Goodman, Brenda Y. Hernandez, Lynne R. Wilkens, Sabine Behrens, Renée Turzanski Fortner, Peter A. Fasching, Christiani Bisinotto, Francisco José Candido dos Reis, Prafull Ghatage, Martin Köbel, Esther Elishaev, Francesmary Modugno, Linda Cook, Nhu Le, Aleksandra Gentry-Maharaj, Usha Menon, María J. García, Cristina Rodriguez-Antona, Kyo Farrington, Linda E. Kelemen, Stefan Kommoss, Annette Staebler, Dale W. Garsed, James D. Brenton, Anna M. Piskorz, David D.L. Bowtell, Anna DeFazio, Susan J. Ramus, Malcolm C. Pike, Celeste Leigh Pearce   +77 more
doaj   +1 more source

Meta-Analysis of the Luminal and Basal Subtypes of Bladder Cancer and the Identification of Signature Immunohistochemical Markers for Clinical Use

EBioMedicine, 2016
Background: It has been suggested that bladder cancer can be divided into two molecular subtypes referred to as luminal and basal with distinct clinical behaviors and sensitivities to chemotherapy.
Vipulkumar Dadhania, Miao Zhang, Li Zhang, Jolanta Bondaruk, Tadeusz Majewski, Arlene Siefker-Radtke, Charles C. Guo, Colin Dinney, David E. Cogdell, Shizhen Zhang, Sangkyou Lee, June G. Lee, John N. Weinstein, Keith Baggerly, David McConkey, Bogdan Czerniak   +15 more
doaj   +1 more source

A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth [PDF]

, 2014
We performed a genome-scale shRNA screen for modulators of B-cell leukemia progression in vivo. Results from this work revealed dramatic distinctions between the relative effects of shRNAs on the growth of tumor cells in culture versus in their native ...
Ehrenberger, Tobias, Fenouille, Nina, Hemann, Michael, Joughin, Brian Alan, Lawton, Lee N., Meacham, Corbin Elizabeth, Pritchard, Justin R., Soto Feliciano, Yadira Marie, Williams, Richard T., Young, Richard A., Zuber, Johannes   +10 more
core   +2 more sources

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source