Results 111 to 120 of about 2,388,117 (306)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

New Strings Gather at the Pear Garden to Evoke the Sound of Unmatched Beauty: The National Sound-Dramatic Rhetorics of Jia Daqun’s Liyuan

Russian Musicology
Professor Jia Daqun’s large-scale national instrumental concerto Impressions of Liyuan is a magnificent work for which the composer consciously selected a musical vocabulary rich in Chinese national characteristics, which refer to appropriate and ...
Dandan Wang
doaj   +1 more source

Students’ acceptance of song lyrics containing national characters

SHS Web of Conferences, 2018
This paper aims at analyzing the acceptance of elementary school students of song lyrics containing national characters. The study was employed using research and development method, and this paper is the result of the interview related to the learning ...
Dwija Iswara Prana, Gunara Sandie, Julia
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

National characteristics and variation in Arabic handwriting [PDF]

From each of four Arabic countries; Morocco, Tunisia, Jordan and Oman, 150 participants produced handwriting samples which were examined to assess whether national characteristics were discernible.
Al-Hadhrami, Ahmed A.N, Allen, Mike, Jones, Allison Elizabeth, Moffatt, Colin   +3 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Pembelajaran Bahasa Indonesia Berbasis Karakter Bangsa Pada Siswa Smk Negeri 2 Tabanan [PDF]

, 2013
This research used a qualitative descriptive design that aims to describe and explain (1) lesson planning, (2) the implementation of learning, and (3) evaluation of learning based on national character education in SMK Negeri 2 Tabanan.The subject of ...
Putrayasa, I. B. (I), Sudiana, N. (N), Yusana, D. M. (D)   +2 more
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Russian national Character "into the very depths" : (analysis of the N. S. Leskov's story "Paddock"). Part 1

Opera slavica, 2015
This article analyzes the features of perception and reflection of the Russian national character in the works of Nikolaj Leskov. The author the most completely considers the story, "Paddock", which is reflected in a concentrated form of Russian society ...
Ol'ga Vadimovna Stukalova
doaj  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source