Results 51 to 60 of about 259,745 (261)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Н.В. Гоголь о Риме и о римском карнавале

Искусство Евразии, 2020
Статья посвящена повести Н.В. Гоголя Рим , в которой воссоздан образ Вечного города 1840-х годов. В слова героя повести молодого римского князя, возвратившегося в Рим из Парижа, писатель вложил свои мысли и эмоциональные впечатления о Риме: о величии ...
Федотова, Елена Дмитриевна
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Adaptive recommendation of student-created micro-lessons based on learning style and knowledge-level modeling

Discover Education
Intelligent tutoring system (ITS) are increasing in both intelligence and precision over time, as the demand for personalization grows and procedures become more standardized.
Doniyorbek Ahmadaliev, Chen Xiaohui, Zhe Zhang, Anvarjon Makhmudov, Mukharramoy Akhmadalieva, Amirov Islombek   +5 more
doaj   +1 more source

“The world is in Amsterdam”: Amsterdam, the Netherlands, and the Dutch in Guinevere Glasfurd’s The Words in My Hand

American and British Studies Annual, 2021
The article presents an imagological study of the recent historical novel The Words in My Hand (2016) by British author Guinevere Glasfurd with the focus on how the Dutch and the 17th century Netherlands are portrayed in the novel, especially regarding ...
Lenka Žárská
doaj  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Semantic Matrix as a Conformation and Development Basis of an Authentic Malagasy Civilization (Review of the book by A.N. Moseyko “Madagascar. Special aspects of the cultural and civilizational development”) [PDF]

Ученые записки Института Африки Российской академии наук, 2019
KOCHANOVA Tatiana Victorovna
doaj   +1 more source