Results 81 to 90 of about 259,745 (261)

Gefühle im „Zeitalter der Reizsamkeit“

Österreichische Zeitschrift für Geschichtswissenschaften
This article discusses the historiography of the cultural historian Karl Lamprecht (1856–1915), a key figure in the interdisciplinary ‘Leipzig School’ school of thought at the turn of the century.
Anja Laukötter
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

New Strings Gather at the Pear Garden to Evoke the Sound of Unmatched Beauty: The National Sound-Dramatic Rhetorics of Jia Daqun’s Liyuan

Russian Musicology
Professor Jia Daqun’s large-scale national instrumental concerto Impressions of Liyuan is a magnificent work for which the composer consciously selected a musical vocabulary rich in Chinese national characteristics, which refer to appropriate and ...
Dandan Wang
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Russian national Character "into the very depths" : (analysis of the N. S. Leskov's story "Paddock"). Part 1

Opera slavica, 2015
This article analyzes the features of perception and reflection of the Russian national character in the works of Nikolaj Leskov. The author the most completely considers the story, "Paddock", which is reflected in a concentrated form of Russian society ...
Ol'ga Vadimovna Stukalova
doaj  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Russian national character "into the very depths" : (analysis of the N. S. Leskov's story "Paddock"). Part 2

Opera slavica, 2016
This article analyzes the features of perception and reflection of the Russian national character in the works of Nikolaj Leskov. The author conciders the most complete story, "Paddock", which is reflected in a concentrated form of Russian society in all
Ol'ga Vadimovna Stukalova
doaj  

National character stereotypes mirror language use: A study of Canadian and American tweets. [PDF]

PLoS One, 2018
Snefjella B, Schmidtke D, Kuperman V.
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source