Results 91 to 100 of about 2,328,556 (303)
Cognitive function in childhood and lifetime cognitive change in relation to mental wellbeing in four cohorts of older people [PDF]
, 2012 Background: poorer cognitive ability in youth is a risk factor for later mental health problems but it is largely unknown whether cognitive ability, in youth or in later life, is predictive of mental wellbeing.
Antonio Verdejo García +9 more
core +4 more sources
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Cognitive Ability and Hemispheric Indecision - Two Surpluses and a Deficit [PDF]
This paper re-examines a finding by Crow et al. (1998) showing that equal skill of right and left hands – hemispheric indecision - is associated with deficits in cognitive ability. This is consistent with the idea that failure to develop dominance of one
Kevin Denny
core +3 more sources
Evaluation of the Restorative Practices Programme of the Childhood Development Initiative [PDF]
, 2013 This report presents the key findings of an independent evaluation, undertaken by the UNESCO Child and Family Research Centre at the National University of Ireland, Galway, of the Restorative Practice Programme, part of the Childhood Development ...
Allyn Fives +4 more
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
BMJ Open, 2019 Introduction Cultivating child health and development creates long-term impact on the well-being of the individual and society. The Amazon of Peru has high levels of many risk factors that are associated with poor child development. The use of ‘community
Christopher Michael Westgard +2 more
doaj +1 more source
Tackling child neglect: key developments in Wales [PDF]
, 2016 This paper on child neglect policy and practice issues in Wales comprises three elements. First we introduce the topic in the context of current family support services that seek to offer early intervention to tackle, inter alia, child neglect and other ...
Crowley, Anne, Pithouse, Andrew Joseph
core
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source