Results 101 to 110 of about 2,328,556 (303)

Associations between maternal exposure to per- and polyfluoroalkyl substances and childhood neurodevelopment up to age 4: The Japan environment and children’s study

Environment International
Background: The link between maternal per- and polyfluoroalkyl substances (PFAS) exposure during pregnancy and child development is inconclusive. Addressing this requires better evaluation methods for mixed PFAS exposures and ensuring comparable outcomes.
Hidetoshi Mezawa, Akifumi Eguchi, Midori Yamamoto, Narumi Tokuda, Masayuki Shima, Shoji Nakayama, Michihiro Kamijima   +6 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Diabetes and Fetal Malformations

Pediatric Neurology Briefs, 1988
Diabetic and healthy control pregnant women were followed in a multicenter collaborative study coordinated by the Epidemiological Branch, National Institute of Child Health and Human Development, Bethesda, MD.
J Gordon Millichap
doaj   +1 more source

Using linked administrative data to aid the handling of non-response and restore sample representativeness in cohort studies: the 1958 national child development study and hospital episode statistics data. [PDF]

BMC Med Res Methodol, 2023
Rajah N, Calderwood L, De Stavola BL, Harron K, Ploubidis GB, Silverwood RJ.   +5 more
europepmc   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Assessing Behavioral Threat Avoidance in Pediatric Anxiety With Naturalistic Games

Mental Health Science
Behavioral avoidance exacerbates anxiety symptoms. Capturing and identifying maladaptive avoidance patterns holds clinical utility. However, effective assessment tools which provide unique information on behavior beyond self‐report are needed.
Purnima Qamar, Eli R. Lebowitz, Rany Abend, Daniel S. Pine, Peter A. Kirk   +4 more
doaj   +1 more source

Social Interaction and Stock Market Participation: Evidence from British Panel Data [PDF]

, 2010
This paper uses data from the British National Child Development Study to investigate the relationship between social interaction and participation in the stock market through holding stocks and/or shares at the individual level. In accordance with
Brown, S., Taylor, K.
core   +1 more source

Exploring household dynamics: the reciprocal effects of parent and child characteristics [PDF]

, 2014
A burgeoning line of literature has shown there are strong effects of maternal mental health on child socio-emotional development (Cummings & Davies, 1994; Downey & Coyne, 1990; Mensah & Kiernan, 2010; Smith, 2004).
Bécares, Laia, Panico, Lidia, Webb, Elizabeth Alice   +2 more
core   +3 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Associations Between Hearing and Cognitive Abilities From Childhood to Middle Age: The National Child Development Study 1958. [PDF]

Trends Hear, 2021
Okely JA, Akeroyd MA, Deary IJ.
europepmc   +1 more source