Results 111 to 120 of about 2,328,556 (303)

Breaking the Darkness: Helping Female Victims of Child Sexual Abuse [PDF]

, 2011
An ongoing study by Valerie Simon, Ph.D., is focused on how to help female victims of child sexual abuse (CSA) get the help they need to avoid sexually risky behavior and its potentially life- altering consequences.
Staff, Editorial
core   +1 more source

Cohort profile: 1958 British birth cohort (National Child Development Study) [PDF]

International Journal of Epidemiology, 2005
Chris, Power, Jane, Elliott
openaire   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Startling responses of zebrafish: an interview with Harold Burgess

BMC Biology, 2018
Harold Burgess is a Senior Investigator at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), part of the National Institutes of Health.
Harold A. Burgess
doaj   +1 more source

Changes in the Relationship between the Outcomes of Cohabiting Partnerships and Fertility among Young British Women: Evidence from the 1958 and 1970 Birth Cohort Studies [PDF]

, 2007
We investigate the effects of a range of time-varying fertility indicators, including pregnancy, and the presence and characteristics of children, on the outcomes of nonmarital unions for two cohorts of British women. We compare the effect of conceptions
Goldstein, Harvey, Joshi, Heather, Kallis, Constantinos, Steele, Fiona   +3 more
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Trends and projections of age-appropriate vaccination coverage in 41 low- and middle- income countries in Asia and Sub-Saharan Africa, 2000–2030

Frontiers in Public Health
IntroductionRoutine immunization programs have focused on increasing vaccination coverage, which is equally important for decreasing vaccine-preventable diseases (VPDs), particularly in low- and lower-middle-income countries (LMICs).
Md Rashedul Islam, Md Rashedul Islam, Md Mizanur Rahman, Md Shafiur Rahman, Md Shafiur Rahman, Md Shafiur Rahman, Sarah Krull Abe, Manas K. Akmatov, Masahiro Hashizume   +8 more
doaj   +1 more source

Economic position and occupational segregation in the 1990s: A comparison of the ONS Longitudinal Study and the 1958 National Child Development Study [PDF]

, 2008
This paper has two aims. The first is to examine the comparability of the 1958 British Birth Cohort Study, known as the National Child Development Study (NCDS) and the Office for National Statistics (ONS) Longitudinal Study (LS), in terms of the ...
Elliott, Jane, Guinea-Martin, Daniel
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source