Results 61 to 70 of about 25,330,745 (203)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Disagreement on estimating cause of death under tuberculosis treatment between the national tuberculosis registry and statistics data in South Korea, 2011–2020

Journal of Infection and Public Health
Background: Disagreement persists regarding the cause of death in patients with tuberculosis (TB) between the national TB registry and vital registration statistics. This study investigated the disagreement and contributing factors between TB-related and
Chiwook Chung, Seung Won Lee, Dawoon Jeong, Hongjo Choi, Hojoon Sohn, Doosoo Jeon, Young Ae Kang   +6 more
doaj   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Hawaii Volcanoes National Park and Vicinity : with geothermal wells

, 1986
Scale 1:100,000 ; universal transverse Mercator projection. (W 155⁰45ʹ00ʺ--W 154⁰47ʹ30ʺ/N 19⁰45ʹ00ʺ--N 19⁰07ʹ30ʺ).1 map : color ; 69 x 100 cm., folded to 26 x 11 cm.Relief shown by contours and spot heights."Compiled from USGS 1:24,000-scale topographic ...
National Park Service, U.S. Geological Survey   +1 more
core   +2 more sources

Association of the triglyceride–glucose index with all-cause and cause-specific mortality in patients with comorbid hypertension and diabetes: A population-based cohort study

American Heart Journal Plus
Study objective: Although the triglyceride-glucose (TyG) index has been shown to be an independent risk factor for either hypertension or diabetes, its association with the coexistence of both conditions remains unclear.
Jiahao Zou, Song Lu, Kaishen Cao, Ruihong He, Xia Feng, Shuang Yang, Wen Liu, Haochen Liu, Zhichao Wang, Ruichun Liao, Jin Chen, Xiaoting Jiang, Xiaoping Peng   +12 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Validation of Mortality Data Sources Compared to the National Death Index in the Healthcare Integrated Research Database

Pragmatic and Observational Research
Aziza Jamal-Allial,1 Todd Sponholtz,1 Shiva K Vojjala,2 Mark Paullin,2 Anahit Papazian,1 Biruk Eshete,2 Seyed Hamidreza Mahmoudpour,3 Patrice Verpillat,3 Daniel C Beachler2 1Safety & Epidemiology, Carelon Research, Newton, MA, USA; 2Safety & Epidemiology,
Jamal-Allial A, Sponholtz T, Vojjala SK, Paullin M, Papazian A, Eshete B, Mahmoudpour SH, Verpillat P, Beachler DC   +8 more
doaj  

Geriatric Nutritional Risk Index and risks of all-cause, cardiovascular, and diabetes-related mortality in adults with obesity: A nationally representative cohort study

American Heart Journal Plus
Objectives: This study aimed to examine the association between the Geriatric Nutritional Risk Index (GNRI) and mortality outcomes, encompassing all-cause, cardiovascular, and diabetes-associated deaths, among adults living with obesity.
Xueqing Yang, Kun Na, Chenghui Yan, Yaling Han   +3 more
doaj   +1 more source

The association between A Body Shape Index and mortality: Results from an Australian cohort.

PLoS ONE, 2017
It is well recognised that obesity increases the risk of premature death. A Body Shape Index (ABSI) is a formula that uses waist circumference (WC), body mass index (BMI) and height to predict risk of premature mortality, where a high score (Quartile 4 ...
Janet F Grant, Catherine R Chittleborough, Zumin Shi, Anne W Taylor   +3 more
doaj   +1 more source