Results 171 to 180 of about 27,553,759 (265)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Substance Use Disorder in a National Heart Failure Cohort: Risk for Hospital Readmission and Mortality. [PDF]

J Clin Med
Yeung SL, Wang M, Lou M, Wiley BM, Ng TMH.   +4 more
europepmc   +1 more source

Excerpt, Oral History Interview, Gene Kono

Excerpt, summary, and index of an oral history interview of Gene Kono. Conducted by Lisa Hirai Tsuchitani, Chizu Iiyama and unknown. Transcribed by Yi-Shen Loo.This oral history interview was conducted for the MIS Oral History Project by the Military ...
Lisa Hirai Tsuchitani, Chizu Iiyama, unknown, Gene Kono   +1 more
core  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Hypertensive Disorders of Pregnancy and Cardiovascular-Kidney-Metabolic Syndrome. [PDF]

Hypertension
Ezzat D, Pabon MA, Li L, Chang A, De Moor N, Yu Z, Cho SMJ, Natarajan P, Spracklen CN, LeBlanc ES, Eaton CB, LaMonte MJ, Stefanick ML, Manson JE, Parikh N, Reiner AP, Roh JD, Soria-Contreras DC, Hoshi RA, Mora S, Demler OV, Powe CE, Honigberg MC.   +22 more
europepmc   +1 more source

Art et Préhistoire au Japon : les Jōmon

Perspective, 2020
Jean-Paul Demoule, Takashi Inada, Laurent Nespoulous   +2 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Association Between the Systemic Immune-Inflammation Index (SII) and the Severity of Coronary Artery Stenosis Based on the Gensini Score in Patients With Chronic Coronary Syndrome Undergoing Coronary Angiography. [PDF]

Cureus
Surya S, Ginanjar E, Nasution SA, Widhani A, Azizi MS, Yulianti M, Shatri H.   +6 more
europepmc   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source