Results 191 to 200 of about 27,553,759 (265)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Disturbance History Shapes Microbial Community Assembly and Predictability in a Continuous Culture System. [PDF]

Environ Microbiol
Renes SE, Bick B, McKie BG, Fried-Petersen HB, Langenheder S, Angeler DG, Lindström ES.   +6 more
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Thirty-day rehospitalization after saphenous vein treatment in France: A nationwide observational study. [PDF]

J Vasc Surg Venous Lymphat Disord
Lareyre F, Chierici A, Gelves AA, Semah J, Creton O, Raffort J.   +5 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

High Pesticide Exposure Events and Self-Reported and Measured Olfactory Dysfunction. [PDF]

JAMA Otolaryngol Head Neck Surg
Song S, Plassman BL, Yuan Y, Luo Z, Pinto JM, Parks CG, Hofmann JN, Beane Freeman LE, Sandler DP, Chen H.   +9 more
europepmc   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

International Forum on the Prevention of ABO Incompatible Red Blood Cell Transfusion: Responses. [PDF]

Vox Sang
Mirrione-Savin A, Murphy MF, Schäfer R, Tiberghien P, Arora S, Dua S, Mueller MM, Tonn T, Diop S, Seck M, Alarimi ZAF, Badawi MA, Sato T, Miyajima A, Wendel S, Fachini R, Petraszko T, Mack J, Cuppari I, Prati D, Nuñez MA, Saa E, Cohn CS, Engel BS, Wood E, Daly J, Ji Y, Zhao Y, Delettre FA, Bourcier V, Pons V, Espasa A, van der Merwe W, Wessels PL, Owusu-Ofori S, John-Teye D, Narayan S, Swarbrick N, Al-Riyami AZ, Dunbar N.   +39 more
europepmc   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Reply to: Data from the ROPAD study corroborate an association between ITSN1 loss-of-function variants and Parkinson's disease. [PDF]

NPJ Parkinsons Dis
Cogan G, Tesson C, Welment L, Clot F, LeGuern E, Lanore A, Dürr A, Cormier-Dequaire F, Debilly B, Planes M, Mangone G, Lesage S, Brice A.   +12 more
europepmc   +1 more source