Results 111 to 120 of about 19,134,440 (286)
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection
Advanced Science, EarlyView.Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse +20 more
wiley +1 more source
Advanced Science, EarlyView.CA9‐targeted PET imaging could be a noninvasive approach to characterize clear cell renal cell carcinoma and associated tumor biology. PET uptake correlates with tumor CA9 expression and is linked to angiogenic activity, immune remodeling, and metabolic reprogramming.
Kailei Chen +19 more
wiley +1 more source
Nation, Social Class and Style: a Comparison of the Humour of Britain and America
Stylistyka, 2006 Historically a much greater range of styles of literary humour were to be found in Bri[1]t sun than in the United States because Bi „.n was a much more hierarchical society with a divined elite and an aristocratic as well as a bourgeois aesthetic.
openaire +1 more source
Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila
Advanced Science, EarlyView.While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li +7 more
wiley +1 more source
L’umorismo nero di Alberto Savinio [PDF]
, 2016 The black humour – privileged by surrealists for its capacity to bring to the surface those psychic contents regarded as taboo, especially those related to death, disease, violence and sexuality (it was Breton himself who coined the expression humour ...
Bulumete, Miruna
core
Advertising and the Organizational Production of Humour [PDF]
, 2014 This chapter discusses humour as it is deliberately produced by organizations through advertising. Using beer advertisements as an example, our aim is to explain the increasing prevalence of advertising-based organizational humour during the period that ...
O'Sullivan, Don, Kavanagh, Donncha
core +1 more source
Advanced Science, EarlyView.Antigenic peptides Aβ42 and E7 self‐assemble into nanofibrils; APTES and TEOS induce SiO2 NP formation on these fibrils to form SiO2@fibril nanovaccines, which activate BMDCs in vitro. In vivo, SiO2@Aβ42 fibril nanovaccines alleviate AD symptoms and clear Aβ42 plaques in APP/PS1 mice, and SiO2@E7 fibril nanovaccines inhibit tumor growth and promote ...
Xuecheng Yang +6 more
wiley +1 more source
Advanced Science, EarlyView.Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon +27 more
wiley +1 more source
The ironic discourse in the works of V. Pyetsukh
Слово.ру: балтийский акцент, 2013 The article identifies the conditions of the realisation of such crucial feature of V. Pyetuskh’s creative method as irony. It is shown that his irony is aimed at the key elements of the Russian identity — the history of Russia and the Russian national ...
Likhina N.
doaj