Results 151 to 160 of about 3,083,966 (343)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote +8 morewiley +1 more sourceAdaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch +16 morewiley +1 more sourcePatient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert +16 morewiley +1 more sourceNational identity predicts public health support during a global pandemic. [PDF]
Nat Commun, 2022 Van Bavel JJ, Cichocka A, Capraro V, Sjåstad H, Nezlek JB, Pavlović T, Alfano M, Gelfand MJ, Azevedo F, Birtel MD, Cislak A, Lockwood PL, Ross RM, Abts K, Agadullina E, Aruta JJB, Besharati SN, Bor A, Choma BL, Crabtree CD, Cunningham WA, De K, Ejaz W, Elbaek CT, Findor A, Flichtentrei D, Franc R, Gjoneska B, Gruber J, Gualda E, Horiuchi Y, Huynh TLD, Ibanez A, Imran MA, Israelashvili J, Jasko K, Kantorowicz J, Kantorowicz-Reznichenko E, Krouwel A, Laakasuo M, Lamm C, Leygue C, Lin MJ, Mansoor MS, Marie A, Mayiwar L, Mazepus H, McHugh C, Minda JP, Mitkidis P, Olsson A, Otterbring T, Packer DJ, Perry A, Petersen MB, Puthillam A, Riaño-Moreno JC, Rothmund T, Santamaría-García H, Schmid PC, Stoyanov D, Tewari S, Todosijević B, Tsakiris M, Tung HH, Umbreș RG, Vanags E, Vlasceanu M, Vonasch A, Yucel M, Zhang Y, Abad M, Adler E, Akrawi N, Mdarhri HA, Amara H, Amodio DM, Antazo BG, Apps M, Ay FC, Ba MH, Barbosa S, Bastian B, Berg A, Bernal-Zárate MP, Bernstein M, Białek M, Bilancini E, Bogatyreva N, Boncinelli L, Booth JE, Borau S, Buchel O, Cameron CD, Carvalho CF, Celadin T, Cerami C, Chalise HN, Cheng X, Cian L, Cockcroft K, Conway J, Córdoba-Delgado MA, Crespi C, Crouzevialle M, Cutler J, Cypryańska M, Dabrowska J, Daniels MA, Davis VH, Dayley PN, Delouvee S, Denkovski O, Dezecache G, Dhaliwal NA, Diato AB, Di Paolo R, Drosinou M, Dulleck U, Ekmanis J, Ertan AS, Etienne TW, Farhana HH, Farkhari F, Farmer H, Fenwick A, Fidanovski K, Flew T, Fraser S, Frempong RB, Fugelsang JA, Gale J, Garcia-Navarro EB, Garladinne P, Ghajjou O, Gkinopoulos T, Gray K, Griffin SM, Gronfeldt B, Gümren M, Gurung RL, Halperin E, Harris E, Herzon V, Hruška M, Huang G, Hudecek MFC, Isler O, Jangard S, Jørgensen FJ, Kachanoff F, Kahn J, Dangol AK, Keudel O, Koppel L, Koverola M, Kubin E, Kunnari A, Kutiyski Y, Laguna O, Leota J, Lermer E, Levy J, Levy N, Li C, Long EU, Longoni C, Maglić M, McCashin D, Metcalf AL, Mikloušić I, El Mimouni S, Miura A, Molina-Paredes J, Monroy-Fonseca C, Morales-Marente E, Moreau D, Muda R, Myer A, Nash K, Nesh-Nash T, Nitschke JP, Nurse MS, Ohtsubo Y, Oldemburgo de Mello V, O'Madagain C, Onderco M, Palacios-Galvez MS, Palomäki J, Pan Y, Papp Z, Pärnamets P, Paruzel-Czachura M, Pavlović Z, Payán-Gómez C, Perander S, Pitman MM, Prasad R, Pyrkosz-Pacyna J, Rathje S, Raza A, Rêgo GG, Rhee K, Robertson CE, Rodríguez-Pascual I, Saikkonen T, Salvador-Ginez O, Sampaio WM, Santi GC, Santiago-Tovar N, Savage D, Scheffer JA, Schönegger P, Schultner DT, Schutte EM, Scott A, Sharma M, Sharma P, Skali A, Stadelmann D, Stafford CA, Stanojević D, Stefaniak A, Sternisko A, Stoica A, Stoyanova KK, Strickland B, Sundvall J, Thomas JP, Tinghög G, Torgler B, Traast IJ, Tucciarelli R, Tyrala M, Ungson ND, Uysal MS, Van Lange PAM, van Prooijen JW, van Rooy D, Västfjäll D, Verkoeijen P, Vieira JB, von Sikorski C, Walker AC, Watermeyer J, Wetter E, Whillans A, Willardt R, Wohl MJA, Wójcik AD, Wu K, Yamada Y, Yilmaz O, Yogeeswaran K, Ziemer CT, Zwaan RA, Boggio PS. +256 moreeuropepmc +1 more source
