Results 141 to 150 of about 1,627,853 (314)

A biodiversity jigsaw: A review of current New Zealand legislation and initiatives [PDF]

, 2012
Purpose: The purpose of this paper is to review the current legislation and initiatives surrounding biodiversity management, protection and sustainable use related to the New Zealand local government sector. Design/methodology/approach: This paper takes
Samkin, Grant, Schneider, Annika Barbara Sabine   +1 more
core   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Horizon scanning: bringing strategic insight to national security policymaking [PDF]

The Australian Government has recently undertaken a number of concrete initiatives to enhance national security policy coordination. As of the date of publication of this paper, some have been implemented, such as the ‘All Hazards National Assessment’ on
David Connery
core  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Soil legacy data rescue via GlobalSoilMap and other international and national initiatives. [PDF]

GeoResJ, 2017
Arrouays D, Leenaars JGB, Richer-de-Forges AC, Adhikari K, Ballabio C, Greve M, Grundy M, Guerrero E, Hempel J, Hengl T, Heuvelink G, Batjes N, Carvalho E, Hartemink A, Hewitt A, Hong SY, Krasilnikov P, Lagacherie P, Lelyk G, Libohova Z, Lilly A, McBratney A, McKenzie N, Vasquez GM, Leatitia Mulder V, Minasny B, Luca M, Odeh I, Padarian J, Poggio L, Roudier P, Saby N, Savin I, Searle R, Solbovoy V, Thompson J, Smith S, Sulaeman Y, Vintila R, Rossel RV, Wilson P, Zhang GL, Swerts M, Oorts K, Karklins A, Feng L, Ibelles Navarro AR, Levin A, Laktionova T, Dell'Acqua M, Suvannang N, Ruam W, Prasad J, Patil N, Husnjak S, Pasztor L, Okx J, Hallet S, Keay C, Farewell T, Lilja H, Juilleret J, Marx S, Takata Y, Kazuyuki Y, Mansuy N, Panagos P, Van Liedekerke M, Skalsky R, Sobocka J, Kobza J, Eftekhari K, Kacem Alavipanah S, Moussadek R, Badraoui M, Da Silva M, Paterson G, da Conceicao Gonsalves M, Theocharopoulos S, Yemefack M, Tedou S, Vrscaj B, Grob U, Kozak J, Boruvka L, Dobos E, Taboada M, Moretti L, Rodriguez D.   +88 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

The impact of science and technology parks on firms´ product innovation: empirical evidence from Spain [PDF]

Science and Technology Parks (STP) are one of the most important and extensive innovation policy initiatives introduced in recent years. This work evaluates the impact of STP on firm product innovation in the Spanish context. Spain is less developed than
Barge-Gil, Andrés, Modrego Rico, Aurelia, Paraskevopoulou, Evita, Vásquez Urriago, Ángela Rocio   +3 more
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

National initiatives to improve outcomes from out-of-hospital cardiac arrest in England. [PDF]

Emerg Med J, 2016
Perkins GD, Lockey AS, de Belder MA, Moore F, Weissberg P, Gray H, Community Resuscitation Group.   +6 more
europepmc   +1 more source