Results 11 to 20 of about 1,618,479 (311)

Upregulated endonuclease Regnase-1 suppresses osteoarthritis by forming a negative feedback loop of catabolic signaling in chondrocytes

open access: yesArthritis Research & Therapy, 2021
Background Ribonucleases (RNases) play central roles in the post-transcriptional regulation of mRNA stability. Our preliminary results revealed that the endonuclease Regnase-1 is specifically upregulated in osteoarthritic chondrocytes. We herein explored
Jeong-In Yang, Jang-Soo Chun
doaj   +1 more source

Agro-morphological diversity of Nepalese naked barley landraces

open access: yesAgriculture & Food Security, 2018
Background Naked barley is a traditional, climate-resilient and highly nutritious crop of the high mountains of Nepal. Knowledge of agro-morphological diversity among the naked barely genotypes is fundamental for their efficient utilization in plant ...
Ritesh Kumar Yadav   +8 more
doaj   +1 more source

National Strategic Computing Initiative [PDF]

open access: yesComputing in Science & Engineering, 2018
The National Strategic Computing Initiative (NSCI) was initiated in 2015 by then-US President Barack Obama, with the goal of accelerating scientic discovery and economic competitiveness by maximizing the benets of high-performance computing (HPC) research, development, and deployment. This special issue presents four papers that illustrate the state of
Rudi Eigenmann, Barry I. Schneider
openaire   +3 more sources

Pontin arginine methylation by CARM1 is crucial for epigenetic regulation of autophagy

open access: yesNature Communications, 2020
Epigenetic regulations of autophagy have emerged as mechanisms for maintaining cellular homeostasis. Here the authors reveal that the CARM1-Pontin-FOXO3a signaling axis can activate autophagy related genes through enhancer activation.
Young Suk Yu   +11 more
doaj   +1 more source

Adipocytes Are the Control Tower That Manages Adipose Tissue Immunity by Regulating Lipid Metabolism

open access: yesFrontiers in Immunology, 2021
Accumulating evidence reveals that adipose tissue is an immunologically active organ that exerts multiple impacts on the regulation of systemic energy metabolism.
Jeu Park   +20 more
doaj   +1 more source

Michal Miloslav Hodža: his national-emancipation and political initiatives [PDF]

open access: yesStudia Politica Slovaca, 2021
The professional ambition of the study is to present the ethnic-emancipatory and national-political initiatives of Michal Miloslav Hodža, one of the representatives of the Slovak national movement in the revolutionary years of 1848-1849, co-creator of ...
Marcela Gbúrová
doaj   +1 more source

Enabling learning through technology: Some institutional imperatives [PDF]

open access: yes, 1995
This paper considers the importance of the institution as the dynamic interpretative element on which will depend the successful integration of the learning technology developed through our national initiatives into the academic curricula of Higher ...
Hodgson, Margaret   +3 more
core   +2 more sources

Multilevel governance challenges in transitioning towards a national approach for REDD+:Evidence from 23 subnational REDD+ initiatives [PDF]

open access: yes, 2015
Although REDD+ was conceived as a national approach to reducing emissions from deforestation and forest degradation, many of the early advances have been at the subnational level. It is critical to link these subnational efforts to emerging national REDD+
Duchelle, Amy E   +4 more
core   +3 more sources

Diversity sourcing of foxtail millet through diversity assessment and on-farm evaluation

open access: yesCogent Food & Agriculture, 2018
Drawing upon the serious food insecurity issues and continually growing impacts of climate change on livelihood, diversity sourcing of climate-resilient, nutritionally rich crops like foxtail millet through diversity assessment and on-farm evaluation ...
Ritesh Kumar Yadav   +4 more
doaj   +1 more source

Managing risk in cancer presentation, detection and referral: a qualitative study of primary care staff views [PDF]

open access: yes, 2014
Objectives In the UK, there have been a number of national initiatives to promote earlier detection and prompt referral of patients presenting to primary care with signs and symptoms of cancer.
Cook, Neil   +2 more
core   +1 more source

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