Results 11 to 20 of about 1,627,853 (314)

Upregulated endonuclease Regnase-1 suppresses osteoarthritis by forming a negative feedback loop of catabolic signaling in chondrocytes

Arthritis Research & Therapy, 2021
Background Ribonucleases (RNases) play central roles in the post-transcriptional regulation of mRNA stability. Our preliminary results revealed that the endonuclease Regnase-1 is specifically upregulated in osteoarthritic chondrocytes. We herein explored
Jeong-In Yang, Jang-Soo Chun
doaj   +1 more source

Agro-morphological diversity of Nepalese naked barley landraces

Agriculture & Food Security, 2018
Background Naked barley is a traditional, climate-resilient and highly nutritious crop of the high mountains of Nepal. Knowledge of agro-morphological diversity among the naked barely genotypes is fundamental for their efficient utilization in plant ...
Ritesh Kumar Yadav, Subash Gautam, Epsha Palikhey, Bal Krishna Joshi, Krishna Hari Ghimire, Rita Gurung, Achyut Raj Adhikari, Niranjan Pudasaini, Rajeev Dhakal   +8 more
doaj   +1 more source

Michal Miloslav Hodža: his national-emancipation and political initiatives [PDF]

Studia Politica Slovaca, 2021
The professional ambition of the study is to present the ethnic-emancipatory and national-political initiatives of Michal Miloslav Hodža, one of the representatives of the Slovak national movement in the revolutionary years of 1848-1849, co-creator of ...
Marcela Gbúrová
doaj   +1 more source

National Strategic Computing Initiative [PDF]

Computing in Science & Engineering, 2018
The National Strategic Computing Initiative (NSCI) was initiated in 2015 by then-US President Barack Obama, with the goal of accelerating scientic discovery and economic competitiveness by maximizing the benets of high-performance computing (HPC) research, development, and deployment. This special issue presents four papers that illustrate the state of
Rudi Eigenmann, Barry I. Schneider
openaire   +3 more sources

Pontin arginine methylation by CARM1 is crucial for epigenetic regulation of autophagy

Nature Communications, 2020
Epigenetic regulations of autophagy have emerged as mechanisms for maintaining cellular homeostasis. Here the authors reveal that the CARM1-Pontin-FOXO3a signaling axis can activate autophagy related genes through enhancer activation.
Young Suk Yu, Hijai R. Shin, Dongha Kim, Seon Ah Baek, Seon Ah Choi, Hyejin Ahn, Amen Shamim, Jeonghwan Kim, Ik Soo Kim, Kyeong Kyu Kim, Kyoung-Jae Won, Sung Hee Baek   +11 more
doaj   +1 more source

Adipocytes Are the Control Tower That Manages Adipose Tissue Immunity by Regulating Lipid Metabolism

Frontiers in Immunology, 2021
Accumulating evidence reveals that adipose tissue is an immunologically active organ that exerts multiple impacts on the regulation of systemic energy metabolism.
Jeu Park, Jeu Park, Jeu Park, Jee Hyung Sohn, Jee Hyung Sohn, Jee Hyung Sohn, Sang Mun Han, Sang Mun Han, Sang Mun Han, Yoon Jeong Park, Yoon Jeong Park, Yoon Jeong Park, Jin Young Huh, Jin Young Huh, Jin Young Huh, Sung Sik Choe, Sung Sik Choe, Sung Sik Choe, Jae Bum Kim, Jae Bum Kim, Jae Bum Kim   +20 more
doaj   +1 more source

Enabling learning through technology: Some institutional imperatives [PDF]

, 1995
This paper considers the importance of the institution as the dynamic interpretative element on which will depend the successful integration of the learning technology developed through our national initiatives into the academic curricula of Higher ...
Hodgson, Margaret, Lewins, Janet, McCartan, Audrey, Watson, Barbara   +3 more
core   +2 more sources

Gifted and talented education in New Zealand schools: A decade later [PDF]

, 2013
In 2004, the Ministry of Education released research investigating identification of and provisions for gifted and talented students in New Zealand Schools (Riley, Bevan-Brown, Bicknell, Carroll-Lind, & Kearney, 2004).
Bicknell, Brenda, Riley, Tracy
core   +1 more source

Diversity sourcing of foxtail millet through diversity assessment and on-farm evaluation

Cogent Food & Agriculture, 2018
Drawing upon the serious food insecurity issues and continually growing impacts of climate change on livelihood, diversity sourcing of climate-resilient, nutritionally rich crops like foxtail millet through diversity assessment and on-farm evaluation ...
Ritesh Kumar Yadav, Achyut Raj Adhikari, Subash Gautam, Krishna Hari Ghimire, Rajeev Dhakal   +4 more
doaj   +1 more source

Estrogen-related receptor γ causes osteoarthritis by upregulating extracellular matrix-degrading enzymes

Nature Communications, 2017
The pathogenesis of osteoarthritis is unclear. The authors show that estrogen-related receptor gamma is upregulated in cartilage from patients and mouse models, where it drives production of matrix-degrading MMPs in chondrocytes, and that its ...
Young-Ok Son, Seulki Park, Ji-Sun Kwak, Yoonkyung Won, Wan-Su Choi, Jinseol Rhee, Churl-Hong Chun, Je-Hwang Ryu, Don-Kyu Kim, Hueng-Sik Choi, Jang-Soo Chun   +10 more
doaj   +1 more source