Results 101 to 110 of about 4,688,224 (312)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

The Discourse of the Power

open access: yesEIRP Proceedings, 2016
Power it's in the middle of the international system. The behavior of each state and the dynamism of the international system rise in the structure and the distribution of the global power.
Adina Elena Sandu, Ciprian Roscaneanu
doaj  

Elections, special interests, and the fiscal costs of financial crisis [PDF]

open access: yes
The author proposes a new approach to explain why the costs of crisis are greater in some countries than in others. He begins with the premise that many crises result from the willingness of politicians to cater to special interests, at the expense of ...
Keefer, Philip
core  

Measuring national interests in the international coffee agreement [PDF]

open access: yes, 2011
This article shows how national interests in price-changing international commodity agreements can be measured. Two approaches are distinguished.
Herrmann, Roland
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

The Pertinence of the Regionalization Project in Romania

open access: yesActa Universitatis Danubius: Administratio, 2010
The concept of “unified” or “homogeneous” state authority (in which the local authorities act as representatives of the central government, equivocally subordinated to its directive and control)was rejected and replaced with a dual system, in which the ...
Mihaela CARAUSAN
doaj  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Ukraine’s policy in Afghanistan

open access: yesRUDN Journal of World History, 2013
The article investigates the process of evolution of Ukraine’s foreign policy in Afghanistan. The author determines the national interests of Ukraine in this state and describes the main stages of cooperation in political, military and economic spheres ...
K Petrovich Kurylev
doaj  

Nuclear power in New Zealand: Attitudes and prospects [PDF]

open access: yes, 2008
Traditional New Zealand attitudes with regard to all things nuclear are subjected to critical scrutiny. It is argued that these may frequently lead us to take policy positions that do not best serve our national interests.
Smith, Ron C.
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

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