Results 91 to 100 of about 177,463,022 (299)

Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran   +13 more
wiley   +1 more source

A peacock near the loading bay at the National Library of Australia, Canberra, 25 August 2011 [picture] /

open access: yes, 2011
Title devised by cataloguer.; Acquired in digital format; access copy available online.; This peacock has taken up residence in the grounds surrounding the National Library of Australia in Canberra, and is affectionately known to some National Library ...
Power, Greg, 1974-
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Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers   +19 more
wiley   +1 more source

The National Library of Australia master key, 7-6-68 [realia] /

open access: yes, 1968
Title from plaque on box.; On obverse: Challenger GMK -- On reverse: 170CL Made in Canada.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn3096453; Exhibited: The Opening Chapter: The National Library of ...
National Library of Australia.
core  

Crossing fitness valleys via double substitutions within codons

open access: yesBMC Biology, 2019
Background Single nucleotide substitutions in protein-coding genes can be divided into synonymous (S), with little fitness effect, and non-synonymous (N) ones that alter amino acids and thus generally have a greater effect.
Frida Belinky   +3 more
doaj   +1 more source

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan   +7 more
wiley   +1 more source

Lincoln Hall at the National Library of Australia, Canberra, 22 September 2007, 1 [picture] /

open access: yes, 2007
Title devised by cataloguer.; Part of the collection: Lincoln Hall at the National Library of Australia, Canberra, 22 September 2007.; Acquired in digital format; access copy available online.; Mode of access: Online.; Photographed by a staff member of ...
Power, Greg, 1974-
core  

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