Results 81 to 90 of about 473,849 (247)

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

Crossing fitness valleys via double substitutions within codons

BMC Biology, 2019
Background Single nucleotide substitutions in protein-coding genes can be divided into synonymous (S), with little fitness effect, and non-synonymous (N) ones that alter amino acids and thus generally have a greater effect.
Frida Belinky, Itamar Sela, Igor B. Rogozin, Eugene V. Koonin   +3 more
doaj   +1 more source

The multiple dimensions of expanded access to health information: Don Lindberg and the U.S. National Library of Medicine. [PDF]

Inf Serv Use, 2022
Humphreys BL.
europepmc   +1 more source

Retractions in Rheumatology: Trends, Causes, and Implications for Research Integrity

Arthritis Care &Research, EarlyView.
Objective We aimed to describe the trends and main reasons for study retraction in rheumatology literature. Methods We reviewed the Retraction Watch database to identify retracted articles in rheumatology. We recorded the main study characteristics, authors’ countries, reasons for retraction, time from publication to retraction, and trends over time ...
Anna Maria Vettori, Michele Iudici
wiley   +1 more source

A resource description framework (RDF) model of named entity co-occurrences in biomedical literature and its integration with PubChemRDF

Journal of Cheminformatics
Named entities, such as chemicals/drugs, genes/proteins, and diseases, and their associations are not only important components of biomedical literature, but also the foundation of creating biomedical knowledgebases and knowledge graphs.
Qingliang Li, Sunghwan Kim, Leonid Zaslavsky, Tiejun Cheng, Bo Yu, Evan E. Bolton   +5 more
doaj   +1 more source

Gene gain and loss push prokaryotes beyond the homologous recombination barrier and accelerate genome sequence divergence

Nature Communications, 2019
A significant proportion of the molecular evolution of bacteria and archaea occurs through gene gain and loss. Here Iranzo et al. develop a mathematical model that explains observed differential patterns of sequence evolution vs.
Jaime Iranzo, Yuri I. Wolf, Eugene V. Koonin, Itamar Sela   +3 more
doaj   +1 more source

History with Heart-and Impact: The National Library of Medicine Michael E. DeBakey Fellowship in the History of Medicine. [PDF]

Methodist Debakey Cardiovasc J, 2021
Reznick JS, Koyle KM.
europepmc   +1 more source

RETRACTION: Identification of Recurrence‐Related MicroRNAs in Hepatocellular Carcinoma Following Liver Transplantation

Molecular Oncology, EarlyView.
RETRACTION: Z.‐B. Han, L. Zhong, M.‐J. Teng, J.‐W. Fan, H.‐M. Tang, J.‐Y. Wu, H.‐Y. Chen, Z.‐W. Wang, G.‐Q. Qiu, and Z.‐H. Peng, “Identification of Recurrence‐Related MicroRNAs in Hepatocellular Carcinoma following Liver Transplantation,” Molecular Oncology 6, no. 4 (2012): 445‐457, https://doi.org/10.1016/j.molonc.2012.04.001.
wiley   +1 more source

Water‐Compatible SuFEx‐Active Diazonium Linchpin Platform for Rapid Modular Diversification and On‐DNA Functionalization

Advanced Functional Materials, EarlyView.
Sulfur fluoride exchange (SuFEx) is a powerful click platform, yet water‐compatible multifunctional linchpins remain elusive. Here, we report decagram‐scalable diazonium linchpins that enable rapid Pd‐catalyzed diversification and direct, catalyst‐free on‐DNA ligation in aqueous media.
Seok Ju Hong, Dong Hyeon Kim, Yujin Lim, Yongseok Kwon, Sangkyu Lee, Han Yong Bae   +5 more
wiley   +1 more source

Large-scale predictions of alternative protein conformations by AlphaFold2-based sequence association

Nature Communications
The many successes of AlphaFold2 (AF2) have inspired methods to predict multiple protein conformations, many of which have biological significance.
Myeongsang Lee, Joseph W. Schafer, Jeshuwin Prabakaran, Devlina Chakravarty, Madeleine F. Clore, Lauren L. Porter   +5 more
doaj   +1 more source